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Biology 2108 Lecture
Physiology:
Respiratory System 

  How can oxygen (a molecule that is not easily stored) be taken into the body at sufficient rates?


organic carbon molecules + O2 -> CO2  + H2O + useable energy
     

How are cellular respiration and the respiratory system related?
Where does cellular respiration occur?



But first, let us consider other organisms:

Plants:
Plant leafs have many openings (stomata) for gas exchange
  


Other animals:
Aquatic animals typically use gills, and much more metabolic energy is devoted to acquiring oxygen.  Why?


Why is blood flow in the opposite direction of water flow (i.e. counter current)?

Why don't terrestrial organisms have gills?

Not all terrestrial respiratory systems are the same.  For example:

Trachea of insects:
      
  
Lungs of birds:



Humans:


Human Lungs, two problems to overcome:

1) Moving air into lungs -> PRESSURE GRADIENT
       
Lungs can be considered as two branched bags suspended in a sealed cavity.
When volume of a sealed container is increased, what happens to pressure?  How will air move along a pressure gradient?  What happens when volume is decreased?

Lungs expand by contracting (lowering) diaphragm and intercostal muscles along ribs.

Pathway of air flow:

                Why is there so much branching?


2) Moving air from lungs into blood -> DIFFUSION GRADIENT

atmospheric pressure X concentration of a gas =  partial pressure (the pressure exerted on a gas)

Do humans go places where this equation becomes important?
         

Rate of diffusion is not only influenced by partial pressure, but also the steepness of the diffusion gradientWhat is the end point of diffusion? 
How does the body prevent equilibrium from being approached?


1. Air movement in lungs (discussed above) maintains high concentration (partial pressure) of oxygen in alveoli.

2. Blood circulation brings blood of low oxygen concentration to lungs (Why is oxygen low as it enters the lungs?).
 
Two adaptations increase (steepen) this concentration gradient:
  • For oxygen, hemoglobin in red blood cells bind with oxygen thus taking it out of solution, lowering the blood concentration of oxygen  (ideal molecule - gives up O2 when O2 low, pH low, or temp high)

  • For carbon dioxide, the enzyme carbonic anhydrase speeds conversion of carbon dioxide to carbonic acid, lowering the blood concentration of carbon dioxide and maintaining the diffusion gradient.



Control of breathing: one of many mechanisms is chemoreceptors stimulated by low pH causes the medulla oblongata to increase breathing rate.  Why is pH an effective way to regulate breathing?


Disorders
Asthma - constriction of muscles surrounding airways. 
        

Bronchitis
- reduced functioning of cilia leading to inflammation


Emphysema - loss of elasticity of the aveoli and extensive scar tissue compromising gas exchange (with smoking as a major cause)

    




Numerous respiratory problems have also been linked to  air pollutants such as  particulates,  sulfer and  nitrogen oxides, hydrocarbons, and ozone.  





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