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Education |
Membership in Professional Honor
Societies |
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Employment |
Publications |
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Experience |
Invited Reviews |
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Honors and Recognition |
Book Chapters |
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Grant Awards |
Abstracts |
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Editorial Boards |
Invited Lectures |
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Institutional Service |
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EDUCATION: |
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1978 to 1979 |
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UNIVERSITY
OF NEW ORLEANS |
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1976 to 1978 |
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UNIVERSITY
OF NEW ORLEANS |
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1967 to 1971 |
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LOUISIANA
STATE UNIVERSITY IN NEW ORLEANS |
| EMPLOYMENT: | ||||
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1979 to Present |
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KENNESAW
STATE UNIVERSITY |
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1978 to 1979 |
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UNIVERSITY
OF NEW ORLEANS |
EXPERIENCE: |
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1990 |
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AD-HOC MEMBER, Small Grants Committee . . . Biological and Neuroscience Subcommittee . . . National Institute of Mental Health. |
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1990,1993 |
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AD-HOC MEMBER, Biomedical Research Review Committee . . .Biochemistry Subcommittee . . . National Institute on Drug Abuse. |
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1993-1995 |
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STUDY SECTION MEMBER, Biomedical Research Review Committee . . .Biochemistry Subcommittee . . . National Institute on Drug Abuse. |
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1995-1999 |
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STUDY SECTION MEMBER, Molecular, Cellular, and Chemical Neurobiology Committee. . . National Institute on Drug Abuse . . .National Institutes of Health. |
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1991-1995 |
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SECRETARY, International Cannabinoid Research Society. |
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1995-1996 |
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PRESIDENT-ELECT, International Cannabinoid Research Society. |
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1996-1997 |
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PRESIDENT, International Cannabinoid Research Society. |
| 1999-2004 |
STUDY SECTION
MEMBER, NIDA K Committee . . . |
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| 2001-2003 | TREASURER, International Cannabinoid Research Society. | ||
GRANT AWARDS: |
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Molecular
Determinants for Cannabinoid Activity: National
Institute on Drug Abuse (P.H. Reggio, Principal Investigator)
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KO2
Career Scientist Award: National
Institute on Drug Abuse (P.H. Reggio, P.I.)
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Dreyfus
Foundation Scholar / Fellow Program for Undergraduate Institutions
(P.H. Reggio, P.I.)
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Cannabinoid
Ligands and Drugs: National
Institute on Drug Abuse (A. Makriyannis, Principal Investigator;
P.H. Reggio, Co-Principal Investigator)
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A
Computational Chemistry Visualization Laboratory: National
Science Foundation
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Academic
- Industrial Undergraduate Research Partnership (AIURP) Fellowship: Council
on Undergraduate Research
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| MEMBERSHIP IN PROFESSIONAL HONOR SOCIETIES: |
| AMERICAN CHEMICAL SOCIETY...Physical, Theoretical, Medicinal Chemistry, and Chemical Education Divisions. |
| AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS...Regular Member. |
| BIOPHYSICAL SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS...Regular Member. |
| COUNCIL ON UNDERGRADUATE RESEARCH...Chemistry Directory Co-Editor, 1996-1997; CUR Quarterly, Issues Editor, 1997-1998. |
| GEORGIA ACADEMY OF SCIENCE...Chair, Chemistry Section, 1989-1990; Secretary, Chemistry Section, 1988-1989. |
| INTERNATIONAL CANNABINOID RESEARCH SOCIETY...President, 1996-1997; President-Elect, 1995-1996; Secretary, 1991-1995. |
| INTERNATIONAL SOCIETY OF QUANTUM BIOLOGISTS AND PHARMACOLOGISTS |
| IOTA SIGMA PI |
| PHI KAPPA PHI (Honor Society) |
| SIGMA XI |
| WOMEN CHEMISTS' COMMITTEE OF THE AMERICAN CHEMICAL SOCIETY (Atlanta Chapter)... Chair 1989- 1990, Secretary 1987-1989. |
PUBLICATIONS (Peer Reviewed Journals only, Student Co-authors Underlined): *SOME PUBLICATIONS CAN BE DOWNLOADED IN PDF FORMAT* |
| S.D.
McAllister, G. Rizvi, S. Anavi-Goffer, D.P. Hurst, J. Barnett-Norris,
D.L. Lynch, P.H. Reggio and M.E. Abood. "An Aromatic Microdomain
at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist
Binding Region." J. Med. Chem. 46, 5139-5152 (2003). *PDF*
P.H. Reggio. "Pharmacophores for Ligand Recognition and Activation/Inactivation of the Cannabinoid Receptors." Current Pharmaceutical Design 9, 1607-1633 (2003). *PDF* J.W. Huffman, R. Mabon, M-J Wua, J. Lu, R. Hart, D.P. Hurst, P.H. Reggio, J.L. Wiley and B.R. Martin. "3-Indolyl-1-naphthylmethanes: New Cannabimimetic Indoles Provide Evidence for Aromatic Stacking Interactions with the CB1 Cannabinoid Receptor." Bioorg. Med. Chem. 11, 539-549 (2003). *PDF* D.P. Hurst, D.L. Lynch, J. Barnett-Norris, S.M. Hyatt, H.H. Seltzman, M. Zhong, Z-H Song, J. Nie, D. Lewis and P.H. Reggio. "N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide Interaction with Lys 3.28(192) is Crucial for Its Inverse Agonism at the Cannabinoid CB1 Receptor." Mol. Pharmacol. 62, 1274-1287 (2002). *PDF* R. Singh, D.P. Hurst, J. Barnett-Norris, D.L. Lynch, F. Guarnieri, P.H. Reggio. "Activation of the Cannabinoid CB1 Receptor May Involve a W6.48/F3.36 Rotamer Toggle Switch." J. Pep. Res. 60, 357-370 (2002). *PDF* J. Barnett-Norris, D.P. Hurst, D.L. Lynch, F. Guarnieri, A. Makriyanis and P.H. Reggio, "Conformational Memories and the Endocannabinoid CB1 Receptor." J. Med. Chem. 45, 3649-3659 (2002). *PDF* J. Barnett-Norris, D.P. Hurst, K. Buehner, F. Guarnieri, J.A. Ballesteros and P.H. Reggio. "Agonist Alkyl Tail Interaction with Cannabinoid CB1 Receptor V6.43/I6.46 Groove Induces a Helix 6 Active Conformation." Int. J. Quantum Chem. 88(1), 76-86 (2002). P.H. Reggio, "Endocannabinoid Structure Activity Relationships for Interaction at the Cannabinoid Receptors," Prost. Leuk. Ess. Fatty Acids 66, 143-160 (2002). *PDF* S.D. McAllister, Q. Tao, J. Barnett-Norris, K. Buehner, D.P. Hurst, F. Guarnieri, P.H. Reggio, K.W. Nowell Harmon, G.A. Cabral and M.E. Abood, "A Critical Role for a Tyrosine Residue in the Cannabinoid Receptors for Ligand Recognition." Biochem. Pharmacol. 7260, 1-16 (2002). P.H. Reggio and H. Traore, "Structure-Activity Relationships for Endocannabinoid Interaction with the Cannabinoid Receptor, the Anandamide Transporter and the Anandamide Amidohydrolase" Chem. Phys. Lipids 108, 15-35 (2000). *PDF*. T. Wang, J.P. Burgess, P.H. Reggio and H.H. Seltzman, "Mild Generation of o-Quinone Methides. Synthesis of (-) Hexahydrocannabinol: Syn. Comm. 30 (8), 1431-1435 (2000). Z.H. Song, C-A Slowey, D.P. Hurst and P.H. Reggio, "The Difference Between the CB1 and CB2 Cannabinoid Receptors at Position 5.46 is Crucial for the Selectivity of WIN55,212-2 for CB2." Mol. Pharmacol. 56, 834-840 (1999). *PDF* Q. Tao, S.D. McAllister, J. Andreassi, K.W. Nowell, G.A. Cabral, D.P. Hurst, P.H. Reggio and M.E. Abood, "Role of a Conserved Lysine Residue in the CB2 Cannabinoid Receptor: Evidence for Sub-Type Specificity" Mol. Pharmacol. 55, 605-613 (1999). *PDF* P.H. Reggio, S. Basu-Dutt, J. Barnett-Norris, M.T. Castro, D.P. Hurst, H.H. Seltzman, M.J. Roche, A.F. Gilliam, B.F. Thomas, L.A. Stevenson, R.G. Pertwee and M.E. Abood, "The Bioactive Conformation of Aminoalkylindoles at the Cannabinoid CB1 and CB2 Receptors: Insights Gained from E and Z Naphthylindenes" J. Med Chem. 41, 5177-5187 (1998). *PDF* J. Barnett-Norris, F. Guarnieri, D.P. Hurst and P.H. Reggio, "Exploration of Biologically Relevant Conformations of Anandamide, 2-Arachidonylglycerol, and Their Analogs Using Conformational Memories" J. Med. Chem. 41, 4861- 4872 (1998). *PDF* P.H. Reggio, T. Wang, A.E. Brown, D.N. Fleming, H.H. Seltzman, G.Griffin, R.G. Pertwee, D.R. Compton, B.R. Martin and M. Abood, "Importance of the C-1 Substituent in Classical Cannabinoids to CB2 Receptor Selectivity: Synthesis and Characterization of a Series of O,2-propano-Delta-8-Tetrahydrocannabinol Analogs,"J.Med. Chem. 40, 3312-3318,(1997). L.C. Hodges, P.H. Reggio and K. Green, "Intraocular Pressure Effects Following Systemic Administration of an Aminoalkylindole and (R)-(+)- Methanandamide in Normotensive Rabbits," Opth. Res. 29, 1-5 (1997). J.W. Huffman, S.Yu, V. Showalter, M.E. Abood, J.L. Wiley, D.R. Compton, B.R. Martin, R.D. Bramblett and P.H. Reggio, "1-Deoxy HU-210: A Potent Cannabinoid with High Affinity for the CB2 Receptor," J.Med. Chem. 39, 3875-3878 (1996). S.G. Lagu, A. Varona, J.D. Chambers, P.H. Reggio, "Construction of a Steric Map of the Binding Pocket for Cannabinoids at the Cannabinoid Receptor," Drug Design and Discovery 12,179-192 (1995). J.W. Huffman, W.K. Banner, G.K. Zoorob, H.H. Joyner, P.H. Reggio, B.R. Martin, D.R. Compton, "Stereoselective Synthesis of the Epimeric _7-Tetrahydrocannabinols," Tetrahedron 51, 1017-1032 (1995). P.H. Reggio, R.D. Bramblett, H. Yuknavich, H.H. Seltzman, D.N. Fleming, S.R. Fernando, L.A. Stevenson, R.G. Pertwee, "The Design, Synthesis, and Testing of Desoxy-CBD: Further Evidence for a Region of Steric Inaccessibility at the Cannabinoid Receptor," Life Sciences 56, 2025-2032 (1995). R.D. Bramblett, A.M. Panu, J.A. Ballesteros, P.H. Reggio, "Construction of a 3D Model of the Cannabinoid CB1 Receptor: Determination of Helix Ends and Helix Orientation," Life Sciences 56, 1971-1982 (1995). P.H. Reggio, "Molecular Modeling at Kennesaw State College Using Chem-X: A Capstone Experience", CUR Quarterly 15, 34-36 (1994). R.E. Venegas, P.H. Reggio, J.R. Rabinowitz, "Theoretical Studies of Crowded Polycyclic Aromatic Hydrocarbons", Polycyclic Aromatic Hydrocarbons, PAH XIII, Garrigues, P. and Lamotte, M., eds., 841-848, Gordon and Breach,Yverdon Switzerland (1993). P.H. Reggio, A.M. Panu, and S. Miles, "The Characterization of a Region of Steric Interference at the Cannabinoid Receptor Using the Active Analog Approach", J. Med. Chem. 36, 1761-1771, (1993). P.H. Reggio, "A Search for Properties Which Produce Discrimination Between Psychoactivity and Analgesic Activity", Int. J. Quantum Chem. 44, 165-179 (1992). R.E. Venegas, P.H. Reggio, and J.R. Rabinowitz, "Computational Studies of the 3- Dimensional Structure of Cyclopenta Polycyclic Aromatic Hydrocarbons Containing a Gulf Region", Int. J. Quantum. Chem. 41, 497-516 (1992). H.H. Seltzman, Y-A Hsieh, C.G. Pitt, and P.H. Reggio, "Synthesis of Rotationally Restricted Tetrahydrocannabinol Ethers", J. Org. Chem. 56, 1549-1553 (1991). P.H. Reggio, G.B. McGaughey, D.F. Odear, H.H. Seltzman, D.R. Compton, and B.R. Martin, "A Rational Search for the Separation of Psychoactivity and Analgesia in Cannabinoids", Pharmacol. Biochem. Behav. 40, 479-486 (1991). P.H. Reggio, H.H. Seltzman, D.R. Compton, W.R. Prescott, Jr. and B.R. Martin, "An Investigation of the Role of the Phenolic Hydroxyl in Cannabinoid Activity", Mol. Pharmacol. 38, 854-862 (1990). P.H. Reggio, V. Frecer, and A.P. Mazurek, "A Molecular Reactivity Template for Cannabinoid Analgesic Activity", Int. J. Quantum Chem., QBS 17, 119-131 (1990). P. H. Reggio, K. V. Greer, and S. M. Cox, "The Importance of the Orientation of the C9 Substituent to Cannabinoid Activity", J.Med. Chem. 32, 1630 (1989). P. H. Reggio and S. Cox, "O,2-propano-delta-8-THC and O,10-methano-delta-9-THC: Two New Cannabinoids Designed to Test the Importance of the Phenol Group to Cannabinoid Activity", Marijuana: An International Research Report, Monograph Series No. 7. G. Chesher, P. Consroe, and R. Musty, eds., pp 285-290, Australian Government Publishing Service, Canberra (1988). P. H. Reggio and A. P. Mazurek, "A Reactivity Template for Cannabinoid Activity," J. Mol. Struc. (Theochem) 149, 331 (1987). P. H. Reggio, S. Topiol, and H. Weinstein, "Molecular Determinants for the Potency of Action of 2- Methylhistamine and 4 Methylhistamine as Histamine H2-Receptor Agonists," J. Med. Chem. 29, 2412 (1986). P.H. Reggio, H. Weinstein, R. Osman, and S. Topiol, "Molecular Determinants for Binding of Methylenedioxytryptamines at 5-HT/LSD Receptors," Int. J. Quantun Chem. Quantum Biol. Symp. 8: 373 (1981). P. Politzer, P.H. Reggio and I.R. Politzer, "Interdisciplinary Cancer Research Workshop", Cancer Research 39, 429, (1979). M. J. Gaertner, P.H. Reggio, C.R. Crosby, III, R. L. Schmidt, and J.A. Mayo, "Intensity Fluctuation Light Scattering by Bacteriophage Particles I. Experimental Study of Morphologically Different Particles", J. Coll. Interf. Sci., 63, 259, (1978). P. Politzer and P.H. Reggio, "Properties of Atoms in Molecules. IV. Atomic Charges in Some Linear Polyatomic Molecules", J. Amer. Chem. Soc., 94, 8308 (1972). G.G. Guilbault and P. Hodapp, "Fluorometric Assay of Uric Acid", Analytical Letters 1, 789 (1968). |
INVITED REVIEWS: |
| P.H.
Reggio, "Pharmacophores
for Ligand Recognition and Activation/Inactivation of the Cannabinoid
Receptors," Current Pharmaceutical Design, 9(20), 1607-1633 (2003).
*PDF* P.H. Reggio, "Endocannabinoid Structure Activity Relationships at the Cannabinoid Receptors," Prostaglandins, Leukot. Essent. Fatty Acids, 66, 143-160 (2002).*PDF* P.H. Reggio and H. Traore, "Structure-Activity Relationships for Endocannabinoid Interaction with the Cannabinoid Receptor, the Anandamide Transporter and the Anandamide Amidohydrolase", Chem. Phys. Lipids 108, 15-35 (2000). *PDF* P.H. Reggio, "Ligand-Ligand and Ligand-Receptor Approaches to Modeling the Cannabinoid CB1 and CB2 Receptors: Achievements and Challenges", Current Medicinal Chemistry 6, 665-683 (1999). P.H. Reggio, "Cannabinoid Pharmacology." Tocris Cookson Pharmaceuticals (1999). R.E. Musty, P. Reggio, and P. Consroe, "A Review of Recent Advances in Cannabinoid Research and the 1994 International Symposium on Cannabis and the Cannabinoids", Life Sciences, 56, 1993-1940 (1995). P.H. Reggio, "Molecular Determinants of Cannabinoid Activity: Towards the Design of Cannabinoid Analgesics with Reduced Psychoactive Liability", NIDA Research Monograph, 134, 210-228 (1993). B.R. Martin, G. Cabral, S.R. Childers, S. Deadwyler, R. Mechoulam, and P. Reggio, "International Cannabis Research Society Meeting. Summary, Keystone, CO (June 19-20, 1992)" Drug and Alcohol Dep., 31, 219-227 (1993). P. H. Reggio, "Molecular Determinants for Cannabinoid Activity: Refinement of a Molecular Reactivity Template," NIDA Research Monograph 79: Structure-Activity Relationships of the Cannabinoids, R. S. Rapaka and A. Makriyannis, eds., pp. 82-95, DHHS, Maryland (1987). |
