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( "!"  #"# ( $#$  %$% ( &%&  '&' ( ('(  )() ( *)*  +*+ ( ,+,  residue #Result 1 Reference 1Result 2 Reference 2Result 3 Reference 3Result 4 Reference 4Result 5 Reference 5Result 6 Reference 6Result 7 Reference 7Result 8 Reference 8Result 9 Reference 9 Result 10 Reference 10 Result 11 Reference 11 Result 12 Reference 12 Result 13 Reference 13 Result 14 Reference 14 Result 15 Reference 15 Result 16 Reference 16343536373839404142434445JY;@JY;@Scripts((((((((((& JY;@JY;@Reports((((((((((& JY;@JY;@Forms&&&&&&&&&&$  hHQ;@hHQ;@UserDefined1@888,,,,,,,* @ hHQ;@hHQ;@SummaryInfok@888,,,,,,,* @N;@N;@MSysRelationships22222222220 N;@N;@MSysQueries,,,,,,,,,,* N;@N;@MSysACEs))))))))))' N;@N;@MSysObjects,,,,,,,,,,* N;@N;@MSysDb2@333'''''''% @N;@N;@Relationships.........., N;@N;@Databases**********( N;@N;@Tables''''''''''% {Q]Uv6S{I @ @ @ @ @ @K3s;@s;@Report3((((((((((& Rq;@s;@Report2@LWF000B@,RF44((((((&  Rq;@Rq;@Report1H@+LWF000l )RF44((((((&  o;@Rq;@Bibliography Report@#LWF000=(^R@@4444442  n;@o;@Residue&LWF000$RF44((((((&  B2m;@n;@Basic Reference 4@#LWF000 !\P>>2222220  k;@B2m;@Basic Reference 3@LWF000\P>>2222220 f;@k;@Basic Reference@LWF000ZN<<000000. 2b;@2b;@MSysModules,,,,,,,,,,* 2b;@2b;@MSysModules2----------+ JY;@JY;@DataAccessPages0000000000. JY;@JY;@SysRel''''''''''% JY;@JY;@Modules((((((((((& JY;@JY;@Scripts((((((((((& JY;@JY;@Reports((((((((((& JY;@JY;@Forms&&&&&&&&&&$  hHQ;@hHQ;@UserDefined1@888,,,,,,,* @ hHQ;@hHQ;@SummaryInfok@888,,,,,,,* @N;@N;@MSysRelationships22222222220 N;@N;@MSysQueries,,,,,,,,,,* N;@N;@MSysACEs))))))))))' N;@N;@MSysO ?.Ic&o#lv)r5~AMG-HzG@ ,-333333@ ,-Gz? ,-Q? ,-(\? ,-? ,-q= ףp? ,-HzG? ,-Q? ,-(\? ,-? ,-p= ף? ,-{Gz?Ret pigm site646 ,-RQ? ,-)\(? ,-?model: alpha 1B bind pocketF. Fanelli, Prot. Eng. 8; 1557; 1995HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH$ ,-ףp= ? ,-Gz? ,-Q? ,-\(\?Ret pig site646 ,-333333? ,- ףp= ? ,-zG? ,-Q? ,-(\? ,-gfffff?Ret Pig site646 ,-> ףp=?proposed to face 7.36 in musc668)))))))))))))))))))))))))))))))))))))))))))& ,-Gz? ,-Q? ,-(\? ,.I UD @@PropData'(-{Gz@ret pig site 646 ,-gfffff@ ,-RQ@ ,-> ףp=@ag bind select ETa/ETb704does not bind directly to cis ret in Pho692subtyp selective. ETa603eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeebMJ" ,-)\(@conttributes to species selection of NK1 antag WIN 51708645DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDA ,-Gz@ ,-@_(42) blue should be able to H bond to 7.49_(202)antag bind site ATa + ess for coupling639affects bind + trigger LH/CG479model: alpha 1B bind pocketsee 1.50hypoth to interact w/ Y 7.43 in AT1A This is imp for activ524mutn impairs coupling w/AC affects pH + Na reg of ag/antag bindneeded for stim of eff sys alpha 2A503imp for activ M1inc Naloxone aff N684subst P bind site in NK1695not dir bind site for cis ret in Phosee 2.53D to A lost coupling, D to Q weak coupling NK1641sl declin ag aff (10 fold)see 3.32ag bind Vlasee 2.57High aff bind + activ: imp LHR478lose coupling if D2.50N or D2.50Q but ret w/D2.50E705is connected via 7.53 + 7.49 who inter w/7.45 + with 5HT2 ligag bind for selec gamma opiod lig.709ag bind653believed to inter w/K in I3 of CCKB Recpt.586reg for effector stim in alpha 2A503Badr. imp for ag bind + coupling573OL,)άol:7ᳫliWWGD!!ߥc`:: ' ,-ףp= @ ,-(\@ ,-Gz@ ,-@ ,-Q@ ,-q= ףp@ ,-\(\@ ,].b_ dSm0 @X@- @Mutn causes Retinitis Pigmentosa710ret pigm site646<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<9,) ,-Q @is arom in beta exc turkey peta causes steric clashes w/certain lig maybe factor in diff aff. Modelsee 3.28tttttttttttttttttttttttttttttttttttttttttttl ,-ףp= @ ,-@ag bind pocket NK2656 ,-Q@ ,-q= ףp@subst P bind siteref 2.50species select site antag NK1B645ag bind pocket NK2656ag (not antag) binding NK1641uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuurXUC@" ,-\(\@ ,-HzG@ ,-333333@ ,-Q@subst P bind sitesee 2.50ag bind pocket NK2656ag bind pocket NK1 Y to F retains ag bind641ccccccccccccccccccccccccccccccccccccccc`74" ,- ףp= @is this near 3.28 Mutn abol trig but notbind LH/CG not affected but only mutn from D to E still triggers479tttttttttttttttttttttttttttttttttttttttttq11 ,-(\@ag bind ATsee ref 5.41 ,-zG@ag bind Vla 1346subst P bind site695ag bind pocket NK2656ag bind pocket NK1641strong ag effect up on mutn to Avla1346~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~zWTB?-* ,-@consti active MSH514 ,-Q@ ,-p= ף@ ,-(\@_(49) orange in ag bind site Vla1346small infl (10 fold) on antag bind M3671subst P bind site in NKIsee 2.50same ut as 7.43 + 3.28 in Rho624M1 antag site631ag effect on mutn Q to A Vla1346ag bind pocket NK2656ag bind pocket NK1641umUR-) ,. BI)B/ @ @-zG @5-HT (IPlink) ag bind574ag bind ite GNRH689contrib to species selec of NK1 antag WIN51708645faces in D21086tttttttttttttttttttttttttttttttttttttpeb41! ,- @C to F constit activ alpha 1B One path only51877777777777777777777777777777777777777777774 ,-Q @ ,-p= ף @dir int site see 6.52in bind pocket M3669ag bind site M2671not direct interaction site TRH1343faces in D21086vvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvrgcDA2/ ,-(\ @int site aminergic recept653mus M3 bind site669affected activin some mutations684antag bind Beta Adr661ag inter Beta 2574loss ag + antag bind D2see 5.46ag bind Vlaref 2.57labeled in Rho by crosslinksee 3.30ag bind653M1 antag site631not dir site in gamma but in pocket1341bind site ags + antags alpha 2A503faces in D21086ag bind site Vla629\\\\\\\\\\\\\\\\\YIE:7ϴpmZW85%" ,-{Gz @ ,-gfffff @crosslink site Rho721 ,-RQ @ag bind Vla1346faces in D21086'''''''''''''''''''''''''''''''''''''''''# ,-> ףp= @_(67) white inter. w/cis ret in Rho necess fo fin708same relative ht as 7.43 + 2.57 in Rho624is W in Beta + parallel stacks w/ ag model665Schiffs base counter ion Rho574Arom ring proximity to 3.32 stabilizes in aminergies574Consti activ Rho575Imp ag binding NK1700used as NKA (ag) bind site in NK2689M1 antag site631ag bind pocket NK2656faces in D21086iiiiiiiiiiiiiiiiiiiiiiieZWEB52沯fc=: ,-)\( @not part of Hx D2 but faces in1086+++++++++++++++++++++++++++++++++++++++++++' ,-Gz @not part of Hx D2 but faces in1086+++++++++++++++++++++++++++++++++++++++++++' ,.I4\YI8Dry-(\@ ,-Q@ ,-{Gz@ ,-)\( @ ,-Gz @model: alpha 1B Bind Pocketsee 1.50,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,$ ,- @imp for coupling in V2 717E3.49R/R3.50E no cooupling in Rho703imp for coupling M1686imp for act M1590ret pig site640}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}znk]ZGD# ,-Q @mut E to R alpha R3.50E in Rho no coupling703must be reg i Rho to maintain resting state of receptor625needed for coupling503needed for recpt coupl alpha 2A503needed for effic G coupl M1needed for effic G couplèpm63 , -ףp= @ ,-(\ @faces in D21086 ,-Gz @ ,- @ ,-Q @ ,-q= ףp @faces in D21086 ,-\(\ @near ret in Rho721 ,-HzG @near retinal in Rhosee 6.48near ret in Rho721Y3.41S results in V no longer bind V2 (could be misfold)617qqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqn63$ ,-333333 @constit activ TSHR506faces in D21086ret pig site646<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<9-) ,-Q @faces in D21086 ,- ףp= @ ,-(\ @near retinal in Rhosee 6.48near retinal in Rho721ag bind site alpha 2A503does not interact dir w/cis-ret in Rho692is not dir inter site TRH344In ETb mutn affirm non-pep. antag bind and affects some ages 10-1000 fold but ET1 bind normally604{xRO:7$ ,V.I Un#] Z#Mdue #d Text15mResult_1Result 1d Text17mReference_1Re-(\@_(123) orange NK1 non-pep antag bind pocket65577777777777777777777777777777777777777777774 ,-Q@ag bind site NK2656 ,-{Gz@ ,-q= ףp@Imp for ag bind site NK1682P needed for proper folding of M3; on lipid gace in Wess model670eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeb$! ,-gfffff@_(119) Yellow ag bind Vlasee 2.57non-pept. NK1 antag bind site655ag bind pocket NK2656ret pig site646ag interaction site Vla1346nk_\JG*" ,-\(\@ ,-RQ@ ,-HzG@ ,-> ףp=@ret pig site646 ,-333333@ ,-)\(@ ,-Q@ret pig site646 ,-Gz@ ,- ףp= @ ,-@lig site M3670 ,-(\@ ,-Q@ ,-zG@contrib to species select NK1 antag WIN 5170864599999999999999999999999999999999999999999996 ,-ףp= @ ,-@ ,-(\@ ,-Q@ ,-Gz@ ,-p= ף@ ,-@ ,M.e(q4}@Lz(] Fm7U` aXbk BinderBinder4The binder that the article is physically -{Gz@ ,-q= ףp@stabil bind pocket NK1577R to C const activ (maybe new C-C)1336HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHD" ,-gfffff@ag bind Il-8609prt of salt br. stabil bind pocket NK1577AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA> ,-p= ף@E2 NK1 bind sites645 ,-{Gz@E2 NK1 bind sites645 ,-q= ףp@E2 NK1 bind sites645 ,-gfffff@ ,-\(\@ ,-RQ@Thrombin R ag site628 ,-HzG@ ,-> ףp=@ ,-333333@e2 loop AT, ag bind site578$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$! ,-)\(@ ,-Q@ ,-Gz@ ,- ףp= @ ,-@ ,-(\@ ,-Q@ ,-zG@ ,-ףp= @ ,-@ ,-(\@ ,-Q@ ,-Gz@ ,-p= ף@ ,-@ag bind AT(faces lipid in CB1)676*******************************************' ,9. gw*] @ @8Reference 8d %Text47m&Result-@rece for folding M3670 ,-(\@ ,-Q@ ,-zG@Y to A lost coupling NK1641$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$! ,-ףp= @ag bind pocket NK2565Differentiates human (S5.46) from rat (A5.46) 5-HT2687ag bind site alpha 2503ag bind site beta 2574inter. site H2574imp for bind and activ alpha 1C6735H2A species differ site589ag inter site alpha ax503̴~khTQ ,-@ ,-(\@ ,-Q@ag bind beta adr663affects NKA(ag) bind but not antag in NK2 in 5/6 interf. see Fig 6689ag bind site beta 25745-HT (IP) ag bind574ag/antag bind + effenciency D11348wta^ ,-Gz@agonist binding AT676ag bind site M3 prob effect on efficiency671D1 ag/antag bind pocket1348imp for activ alpha 1C but not bindag bind, imp for coupling643abst 2182673ag bind AT578ag bind AT677not imp for ag bind alpha 2A503ag bind AT2598inter site in H2574folding beta; in bind pocket663mus M3669no ag bind alpha 2A503HHHHHHHHHHHHHHHHHE2/)& ǽeaJG ,-p= ף@ ,-@ ,-(\@antag bind site used in Donnelly NK2 model as ag bind site689primary int site NK1577antag/ag site NK2656ag site NK1 (not antag)641ag bind site IL-8496ag bind site M3671Ach bind site574in bind site M3669proposed antag site NK1694faces Hx 6, Hx3 (see Fig 6) non-peptide NK1 antag bind site655Imp for ag bind NK1682AAAAAAAAAAAAAAAAAAAAAAA>+(qn]ZFC ,-Q@amino arom inter NK1658const activ alpha 1B518Y to C const activ VP2565may be new C-C formedeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeePM74  ,o.I U&E`-47U`PaX bkResult 9Result 9Result_9d5U``aX b`cText49 Result 9:m7U`Pa8"bk Reference 9-333333@constit activ TSHR594imp for coupling along w/6.31 + 6.32 M3602const activ TSHR506[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[[XHE ,-)\(@Constit activ Beta 2493constit activ TSH505444444444444444444444444444444444444444441  ,-Q@Constit activ Beta 2493  ,-(\@ ,-Q@imp for coupling M3, must be changed4870000000000000000000000000000000000000000000- ,-Gz@imp for coupling M3, must be changed4870000000000000000000000000000000000000000000- ,-p= ף@mutn in M2 caused coupling to diff effector47377777777777777777777777777777777777777777774 ,-@ ,-(\@mutn in M2 caused coupling to diff effector47377777777777777777777777777777777777777777774 ,-Q@ ,-{Gz@must be arom in musc MB to couple to PI64233333333333333333333333333333333333333333330 ,-q= ףp@ ,-gfffff@ ,-\(\@_(148) should be near 6.37 _(164)******************************************** ,-RQ@_(147) should be near 6.37 _(164)imp for coupling (PI)640imp for coupling to Gq in M501an arom AA imp for coupling in M3642imp for coupling in M3640`]B?** ,-HzG@ ,-> ףp=@ ,-333333@ ,-)\(@ ,-Q@ ,-Gz@ ,- ףp= @ ,.`ODP:m0-(\@ ,-Q@ag bind AT1see ref 5.41ag bind AT1598is close to retinal in Rho701near ret in Rho721Lig bind site M3670crosslink site in Rho study D3.52 mutn???pm]ZKH.+  ,-zG@ret pig site646 ,-ףp= @ ,-@ ,-(\@const activ LHR652TSHR mutn prod constit activ485TSHR mutn const activ506RRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRO:7 ,-Q@imp for const activ LHR486TSHR mutn prod constit activ485BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB?# ,-Gz@imp const activ LHR486,  ,-p= ף@ ,-@ ,-(\@ ,-Q@ ,-{Gz@_(164) should be near 6.58_(147) + 6.59_(148) const activ LHR486constit activ LHR486]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]ZIF ,-q= ףp@ ,-gfffff@ ,-\(\@constit activ alpha 1B637A(6.34)L improved coupling606constit activ beta 2622constit activ TSHR505constit activ LHR490constit activ TSHR594constit activ beta 2513constit activ alpha 1B605constit activ 2637loss of coupling to PI but not to cAMP597constit activ TSH505|khVS?<" ,-RQ@constit activ TSH595 ,-HzG@imp for coupling M3 along w/ 6.30 + 6.31 must be changed602DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDA ,-> ףp=@imp for coupling M3 along w/ 6.30 + 6.32 must be changed602K to H improved activation in alpha 1606llllllllllllllllllllllllllllllllllllllllliDA ,.uWRDu8LaserJe-333333@ ,-)\(@e2 loop AT1 bind site578!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! ,-Q@ ,-gfffff@ ,-\(\@const activ w/6.58873primary inter site NK-1577888888888888888888888888888888888888888885 ,-RQ@ag bind AT1see 5.41const activ w/6.59873ag bind but not antag aff NK2689ag bind IL-8496ag bind AT1598nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnk`]QN1. ,-HzG@ ,-> ףp=@ ,-333333@ag bind site Vla1346ag site beta 2574D2 mutn to L affected bind of one portion of one ??? of antags674antag bind site NK2656ol.+ ,-)\(@ag bind ATsee ref 5.41ag bind AT1676-----------------------------------------* ,-Q@Resp for Cp selectiv in NK1 (along w/e2 residues)645===========================================: ,-Gz@_(179) white imp for bind + activ. TRH517Ach inter site574red ag + antag aff684ess for some 5HT2a ag binding613E to L??? binding of some 5HT ags612ag site in M3500antag site M thought it could be constit activ; antag bind site NK2500antag/ag bind site NK2656ag bind (not antag) NK1641ag site in M3500arom Inter Beta 2 w/agNK1 antag bind574mod lambda in Rho570needed in bind pocket A2a672non-pept. antag NK1 bind site655Beta 3 lig bind702ag bind NK1682antag NK1 bind pocket (maybe part of aromatic stack)660ɾpm\YKK52%" ﬩xuXUC@2/ #,- ףp= @antag bind AT1647arom is ??? helps ??? D3.52 Mutnnear ret in Rho721ag bind imp M3671In bind pocket M3669antag/ag bind site NK2656ag bind pocket + imp for coupling M3643qn]ZLI:: ,-@proline imp for fold M3670P6.50R mutn loss of V bind in V2 could be lisfold617WWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWT# ,\. -,~#$*3-Gz@dir int site A2a672probably on water access face1170=========================================9 ,-p= ף@ ,-@arom stabil inter should be accessible from inside w/ D3.32 aminergies574modulates lambda in Rho574water access1170|||||||||||||||||||||||||||||||||||||||xliRO ,-(\@_(192) white ligand bind site beta adr593Interacts w/ Hx1 in alpha2 and beta 21351in bind pocket M3669lig bind site beta 2593imp for ag bind + activsee ref 6.52imp for beta 2 ig bind???faces Hx1 and 2 in beta adrenergic???M1 antag bind site631indir inter site 5HT1D618antag/ag NK2656species selectivity 5HT1b626F to N turns from alpha 2 antag to beta antag site1355water access1170vr@=$!¿ol[W2/ ,-Q@slight improv ag bind NKB + antag in NK2 see Fig 6689faces Hxs 3+ 6 in beta adrenigic???crucial for species select of NK1 antag CP96345645resp for higher aff of NK1 rat vs human for CP96,345644water access1170Ǔa^>; ,-{Gz@faces lipid in beta adrenasie???water accessible1170=========================================9)& ,-q= ףp@_(189) orange proposed to face 1.39 in musc668water access1170confus specif for R8 in GNRH650fffffffffffffffffffffffffffffffffffffffcGC74 ,-gfffff@_(188) blue ag bind site NK1682water accessible 1170Y to A ag affected, Y to H SP bind restored, Y to F SP + RR bind restored NK1641non peptide antag NK1 site655antag site NK2656=9(% ,-\(\@water acessible1170 ,-RQ@ ,-HzG@resp for beta vs A selec in Gastrim (CCKB)R ref 11586TRH bind site1343ag bind site NK2656bbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbb_OK>; ,-> ףp=@ ,m.r5u_4f  @Field38)ReportFooter4-> ףp=@ ,-333333@ ,-)\(@should face out + doesn't630%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%" ,-Q@inter acts w/7.49 to D2.50 this cluster inter w/ 7.45 D679model alpha 1B bind pocket???not bind site but imp for transd in AT2489water access1170`]C@ ,-Gz@sty out/may be for fold ,- ףp= @in Hx1/Hx7 interface ,-@proline key residue in M3 activ (PI)669imp for fold M3670water access1170RRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRNB?0- ,-(\@_(202) magenta should be able to H bond to 2.50M3 mutn inc ag bind slightly, impaired coupling670w/7.53 interacts w/D2.50 also w/7.53 inter w/7.45 + in turn w/ 5HT2 lig679model alpha 1B bind pocket???water access1170δjg88 ,-Q@ ,-zG@constit activ TSHR506 ,-ףp= @imp for bind antag AT648stabil inter of ag w/3.32574probably on water access face1170^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^Z=:! ,-@close to facing out dec ag bind beta adr653interacts w/ cluster D2.50/7.49/7.53679water access1170kkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkkg[X41 ,-(\@ ,-Q@_(196) yellow should be accessibe from inside is facing inphoto labeled in Rho721site of Schiff base link in Rho708constit activ Rho887is at same ht as 3.28 + 2.57 in Rho624part of salt ??? in Rho865Imp for coupling to PC in AT1a (hypoth inter between 7.43 + D2.50)524M1 antag bind site631ret pig site646water access1170water access1170YYYYYYYYYYYYYYYYYYYYYYYUIE96*'Ͷ|yZWCC ,.z{>S_"bcText13 Page Begin:m`(ab kPage EndPage EndArticle's ending page numberPage_Endd`abcText15 Page End:m0`(abpkYearYearFixedYear of article publicationd`ab@cText17Year:m`(aP `nal the reference is found ind`abcText9Journal:m`(ab kVolumeVolumeJournal's volume numberd`abcText11Volume:m`(adb k Page Begin Page BeginArticle's beginning page number Page_Begind``ad_Line39faxbLine40fabLine41fa8bLine42` PageHeader0`|Detail1m`(axbpIDID!Number of entries in the databased`axbcText7Record Number:m`(ab kJournalJournal-Name of the jour^:d78d eTimes New Romanl37gm59<c,gi Times New Roman`t ReportHeader3d7axbcdText36Basic Referencem ;a-@ ,-(\@ ,-Q@ ,-Gz@ ,-p= ף@ ,-@ ,-(\@ ,-Q@T7.63A blocks M3 seuest678########################################### ,-{Gz@T7.62A blocks M3 seques678########################################### ,-q= ףp@ ,-gfffff@ ,-\(\@T7.59A blocks M3 seques678########################################### ,-RQ@Rho K 7.58 stop mutn couldn't bind cis-ret135377777777777777777777777777777777777777777773 ,-HzG@indiv mutn to A from 7.57 to 7.62 did not disrupt Rho bind or trigger1353RRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRN ,VCPN ???pJ$I,    $2  2  2  '2       '    6            IDJournalVolume Page BeginPage EndYear Main AuthorUnderlined Author Other AuthorsBinder Article Title BookTitleEditor PublisherLocation ? 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LoeweCB SAR II A/LOptically Active Synthetic Tetrahydrocannabinols; d- and l-1-Hydroxy-3-n-amyl-6,9,9-trimethyl-7,8,9,10-tetrahydro-6-dibenzopyrans.@3  }=7116241628Roger AdamsMorton Harfenist and S. LoeweCB SAR II A/LNew Analogs of TetrahydrocannabinoliiiiiF9  }<Pain4795103R. ZeltserZ. Zeltser, A.Eisen, J.J. Feigenbaum and R. MechoulamCB Analgesia]]]]]]Q  ;J.Clin Pharmacol21334S340STony L. Yaksh, Ph.D.CB AnalgesiaThe Antinociceptive Effects of Intrathecally Administered Levonantradol and Desacetyllevonantradol in the RatA555! :The J. of Pharmacology & Experimental Therapeutics265633639Sandra P. WelchCB AnalgesiaBlockade of Cannabinoid-Induced Antinociception by Norbinaltorphimine, but not N, N-Daillyl-Tyrosine-Aib-Phenylalanine-Leucine, ICI 174,864 or Naloxone in Mice]QQQB?<9 9The J. of Pharmacology & Experimental Therapeutics2621018Sandra P. WelchDavid L. StevensCB ANALGESIAAntinociceptive Activity of Intrathecally Administered Cannabinoids Alone, and in Combination with Morphine in Micek_OO@><9 8The J. of Pharmacology & Experimental Therapeutics272310321Sandra P. WelchCharity Thomas and Gray S. PatrickCB ANALGESIAModulation of Cannabinoid-Induced Antinociception After Intracerebroventricular Versus Intrathecal Administration to Mice: Possible Mechanisms for Interaction with Morphine,,,,,sQQB?<9 i>VsHBrain Research688114120M. Todd Kirby*Robert E. Hampson, Sam A. DeadwylerAminoalkylindolesCannabinoids selectively decrease paired-pulse facilitation of perforant path synaptic potentials in the dentate gyrus in vitro`O,, GThe J. of Pharmacology & Experimental Therapeutics26311181126David R. ComptonLisa H. Gold, Susan J. Ward, Robert L. Balster and Billy R. MartinAminoalkylindolesAminoalkylindole Analogs: Cannabimimetic Activity of a Class of Compounds Structurally Distinct from Delta9-Tetrahydrocannabinol'''''TTD@<9 FJ. Med. Chem3410991110Malcolm R. BellThomas E. D'Ambra, Virendra Kumar, Michael A. Eissenstat, John L. Herrmann, Jr. Joseph R. Wetzel, David Rosi, Richard E. Philion, Sol J. Daum, Dennis J. Hlasta, Rudolph K. Kullnig, James H. Ackerman, Dean R. Haubrich, Daniel A. Luttinger, Eugene R. BaizmaAminoalkylindolesAntinociceptive (Aminoalkyl)indoles_____<+,, ENIDA295296F.M. CasianoR. Arnold, D. Haycock, J. Kuster, and S.J. WardAminoalkylindolesPutative Aminoalkylindoles (AAI) Antagonists]L  {DNIDA427428M. A. EissenstatM.R. Bell, T.E. D'Ambra, K.G. Estep, D.A. Haycock, E.M. Olefirowicz and S.J. WardAminoalkylindolesAminoalkyindoles (AAIs): Structurally Novel Cannabinoid-Mimeticsăr!!  {CNIDA300301K.G. EstepT.E. D'Ambra, E.M. Olefirowicz, M.R. Bell, M.A. Eissenstat, D.A. Haycock, and S.J. Ward.AminoalkylindolesConformationally Restrained Aminoalkyindoles: Potent, Stereoselective Ligands at the Cannabinoid Binding Sites  {BNIDA304305D. A. HaycockJ.E. Kuster, J.I. Stevenson, S.J. Ward, and T.D'AmbraAminoalkylindolesCharacterization of Aminoalyindole Binding: Selective Displacement by CannabinoidsdS  {ANIDA302303J.C. MoldovanS.J. Ward, and A.S. BloomAminoalkylindolesCannabinoid-Like Effects of Aminoalkylindole Compounds on the Physical PropertiesH7  {0>u*FNJ. of Medicinal Chemistry2011461152Peter GundT.Y. ShenAminoalkylindolesA Model for the Prostaglandin Synthetase Cyclooxygenation Site and Its Inhibition by Antiinflammatory Arylacetic AcidsN=44*&"  MThe J. of Pharmacology & Experimental Therapeutics27113831390Fang FanDavid R. Compton, Susan Ward, Lawrence Melvin and Billy R. MartinAminoalkylindolesDevelopment of Cross-Tolerance Between Delta 9- Tetrahydrocannabinol, CP 55,940 and WIN 55,2121LLD@<9 LMolecular Pharmacology48443450Christian C. FelderKelly E. Joyce, Eileen M. Briley, Jaleh Mansouri, Ken Mackie, Oliver Blond, Yvonne Lai, Alice L. Ma and Richard L. MitchellAminoalkylindoles/CB RECEPTOR/AAEComparison of the Pharmacology and Signal Transduction of the Human Cannabinoid CB1 and CB2 Receptors99999Գ88%" KJ. Med. Chemistry3830943105Michael A. EissenstatMalcolm R. Bell, Thomas E. D'Ambra, E. John Alexander, Sol J. Daum, James H. Ackerman, Monte D. Gruet, Virendra Kumar, Kimberly G. Estep, Edward M. Olefirowicz, Joseph R. Wetzel, Michael D. Alexander, John D. Weaver, II, Dean A. Haycock, et al.AminoalkylindolesAminalkylindoles: Structure-Activity Relationships of Novel Cannabinoid Mimetics<+77" JJ. Med. Chem35124135Thomas E. D'AmbraKimberly G. Estep, Malcolm R. Bell, Michael A. Eissenstat, Kurt A. Josef, Susan J. Ward, Dean A. Haycock, Eugene R. Baizman, Frances M. Casiano, Nettie C. Beglin, Susan M. Chippari, John D. Grego, Rudolph K. Kullnig and Gregory T. DaleyAminoalkylindolesConformationally Restrained Analogues of Pravodoline: Nanomolar Potent, Enantioselective, (Aminoalkyl)indole Agonists of the Cannabinoid Receptor),, IThe J. of Pharmacology & Experimental Therapeutics273734743Sam A. DeadwylerRobert E. Hampson, Jian Mu, Antra Whyte and Steven ChildersAminoalkylindolesCannabinoids Modulate Voltage Sensitive Potassium A-Current in Hippocampal Neurons Via a cAMP-Dependent Process RRB?<9 >TD|VXiang-Qun XieMichael Eissenstat and Alexandros MakriyannisAminoalkylindolesCommon Cannabimimetic Pharmacophoric requirements between Aminoalkylindoles and Classical CannabinoidsRA aUBr. J. Pharmacol11014831490R.G. PertweeL.A. Stevenson & G. GriffinAminoalkylindolesCross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamideZI.." TThe J. of Pharmacology and Experimental Therapeuti257170183Mary PachecoSteven R. Childers, Renee Arnold, Frances Casiano and Susan J. Ward.AminoalkylindolesAminoalkylindoles: Actions on Specific G-Protein-Linked Receptors壒NNB?<9 STetrahedron Letters3614011404Julia A. H. LaintonJohn W. Huffman, Billy R. Martin and David R. ComptonAminoalkylindoles1-Alkyl-3-(1-naphthoy)pyrroles: A New Class of Cannabinoid}l77$  RBioorganic & Medicinal Chemistry Letters5381386Virendra KumarMichael D. Alexander, Malcolm R. Bell, Michael A. Eissenstat, Frances M. Casiano, Susan M. Chippari, Dean A. Haycock, Daniel A. Luttinger, Joan E. Kuster, Matthew S. Miller, Joan I. Stevenson and Susan J. WardAminoalkylindoles/AAIsMorpholinoalkylindenes as Antinociceptive agents: novel cannabinoid receptor agonists+DD630/ QBrain Research57593102Elizabeth M. JansenDean A. Haycock, Susan J. Ward and Virginia S. SeyboldAminoalkylindolesDistribution of cannabinoid receptors in rat brain determined with aminoalkylindoleswf00 PActa CrystC5113411345Sandra IanelliMario Nardelli and Daniele BellettiConformation at the Amide N Atom of 1-Carboxmide Indole DerivativesMM** OBioorgarnic & Medicinal Chemistry Letters4563566John W. HuffmanDong DaiAminoalkylindolesDesign, Synthesis and Pharmacology of Cannabimimetic Indoles_NFF7410 >d^European J. of Pharmacology202373378Jody E. MarguliesRonald P. Hammer, Jr.CB METABOLISMDelta9-Tetrahydrocannabinol alters cerebral metabolism in a biphasic, dose-dependent manner in rat brain^Q<<+(%" ]The American Society for Pharmacology and Experime1810651070N. K. BrownD.J. HarveyCB METABOLISMIn Vitro Metabolism of Cannabichromene in Seven Common Laboratory AnimalsfYNNC?;9 \Neuropharmacolgy17137144A. L. GoughJ. E. OlleyCB METABOLISMCatalepsy Induced by Intrastriatal Injections of Delta9-THC and 11-OHDelta 9-THC in the RatB5** [Chem Pharm Bull3816971701Hiroshi GohdaShizuo Narimatsu, Ikuo Yamamoto and Hidetoshi YoshimuraCB METABOLISMIn Vivo and in Vitro Metabolism of Cannabidiol Monomethyl Ether and Cannabidiol Dimethyl Ether Guinea Pig: On the Formation Mechanism of Cannabielsoin-Type Metabolity from Cannabidiol88888qd--  ZMolecular Pharmacology40228234Lester M. BorheimMaria Almira CorreiaCB METABOLISMPurification and Characterization of the Major Hepatic Cannabinoid Hydroxylase in the Mouse: A Possible Member of the Cytochrome P-450IIC SubfamilyWJ66%" YThe American Society for Pharmacology and Experime23825831Lester M. BornheimKelly Y. Kim, Jianmin Li, Beatrice Y. T. Perotti and Leslie Z. BenetCB METABOLISM/CB METABOLISMEffect of Cannabidiol Pretreatment of the Kinetic of Tetrahydrocannabinol Metabolites in Mouse BrainSSA>;9 XScience16812281229I. M. NilssonS. Agurell, J.L. G. Nilsson, A. 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Therapeutics19218221Kazuhito WatanabeNoriko Hirahashi, Shizuo Narimatsu, Ikuo Yamamoto and Hidetoshi YoshimuraCB METABOLISMMouse Hepatic Microsomal Enzyme that Catalyzes Oxidation of 11-Oxo-Delta 8-Tetrahydrocannabinol to Delta 8-Tetrahydrocannabinol-11-OIC Acid33333RRA>;9 oBiochemical Pharmacology4317291736Shizuo NarimatsuYuko Akutsu, Tamhide Matsunaga, Kazuhito Watanabe, Ikuo Yamamoto and Hidetoshi YoshimuraCB METABOLISMImmunochemical Characterization of a Cytochrome P450 Isozyme and a Protein Purified from Liever Microsomes of Male Guinea Pigs and Their Roles in the Oxidative Metabolism of Delta9-Tetrahydrocannabinol by Guinea Pig Liver Microsomes99)%! > t15iCActa Cryst.B3332113214Peter G. JonesLarry Falvello, Olga Kennard and George M. SheldrickCB StructureCannabidiolvvvvvk_++ Science604606Leh-Yeh HsuC.E. NordmanCB StructurePhase Transition and Crystal Structure of the 37degreeC Form of Cholesterol7+ {~Tetrahedron2214811488Y. GaoniR. 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SikemeierCB StructureUnwandlung von (-)-Delta6,1-3,4-trans-Tetrahydrocannabinol in (-)-Delta 1,2-3-trans-Tetrahydrocannabinol?3'' Acta Chemica ScandinavicaB31749755T. OttersenE. RosenqvistCB StructureThe Crystal and Molecular Structure at -165C of the 1:1 Molecular Complex Formed by 8Beta-Hydroxy-Delta9-tetrahydrocannabinol and N, N-DimethylformamideMA44)&#  Acta CrystB3332113214Peter G. JonesLarry Falvello, Olga Kennard and George M. SheldrickCB StructureCannabidioluuuuuj^** Acta Chemica ScandinavicaB31781787T. OttersenE. Rosenqvist, C.E. Turner and F.S. El-FeralyCB StructureThe Crystal and Molecular Structure of Cannabinolma44)&#  J. Med. Chem23220223Ilana TamirRaphael MechoulamCB StructureCannabidiol and Phenytoin: A Structural ComparisonvvvvvC7&& Molecular Pharmacology35495503R. W. KriwackiA. MakriyannisCB StructureThe Conformational Analysis of Delta9-and Delat9,11-Tetrahydroccaninols in Solution using High Resolution Nuclear Magnetic Resonance SpectroscopyMA33%" J. of Natural Products47138142Andrew T. McPhailHala N. Elsohly, Carltone E. Turner, and Mahmoud A. ElsohlyCB StructureStereochemical Assignments for the Two Enantiomeric Pairs of 9.10-Dihydroxy- Tetrahydrocannibinols. X-ray Crystal structure analysis of (+)-Trans-Cannabitriol}q66%" }> Y3G169178Louis LembergerCB StructurePharmacokinetics of Delta-9-Tetrahydrocannabinol and its Metabolites: Importance and Relationship in Developing Methods for Detecting Cannabis in Biologic FluidsMarihuana: Chemistry, Biochemistry, and Cellular EffectsGabriel G. NahasSpringer-VerlagNew York*"(  y~ J. of Pharmacokinetics and Biopharmaceutics10495506Gene BarnettChia-Whei N. Chaing, M. Perez-Reyes and S.M. OwensCB StructureKinetic Study of Smoking MarijuanaxFF:742 Journal of Pharmaceutical Sciences74171174Elliott PerlinCarol G. 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WidmanCB SAR II A/LCannabinoids: Metabolites Hydroxylated in the Pentyl Side ChainMarihuana: Chemistry, Biochemistry, & Cellular EffectsGabriel G. Nahas, William D.M. PatonSpringer-Verlag1976EA2ח  yJ. Amer. Chem. Soc.6420872089Roger AdamsC.M. Smith and S. LoeweCB SAR II A/LOptically Active Synthetic Tetrahydrocannabinols; d- and l-1-Hydroxy-3-n-amyl-6,9,9-trimethyl-7,8,9,10-tetrahydro-6-dibenzopyrans. XIV1TF//$  J. Amer.Chem.Soc.7116241628Roger AdamsMorton Harfenist and S. LoeweCB SAR II A/LNew Analogs of Tetrahydrocannabinol. XIXXJ--" 228238Brian M. SadlerMonroe E. Wall, Mario Perez-ReyesCB StructureThe Pharmacokinetics of Delta-9-Tetrahydrocannabinol in Man After Simultaneous Intravenous and Oral AdministrationThe Cannabinoids: Chemical, Pharmacologic and Therapeutic AspectsS. Agurell, W.L. Dewey and R.B. 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Microbial Transformation of (-)-Delta-'-3,4-trans-Tetrahydro-cannabinol by Cunninghamella blakesleeana LenderC555'# {>,^317326William. DeweyBilly R. Martin and Everette L. MayCB SAR II A/LCannabinoid Stereoisomers: Pharmacological EffectsCRC Handbook of Stereoisomers: Drugs in PsychopharmacologyDonal F. Smith, Ph.D., Dr. MedCRC Press, Inc.Boca Raton, FloridaغL>  yArch. int. Pharmacodyn196133145W. L.. DeweyL. S. Harris and J. S. KennedyCB SAR II A/LSome Pharmacological and Toxicological Effects of 1 trans-Detal-8 tetrahydrocannabinol in laboratory Rodents (1)^P22&#  Life Sciences3612991306S. DalterioD. Mayfield, A. Bartket and W. MorganCB SAR II A/LEffects of Psychoactive and Non-Psychoactive Cannabinoids on Neuroendocrine and Testicular Responsiveness in Mice\N)) J. Med. Chem25596599Paul ConsroeArnold R. Martin, and Barbara Schneiderman FishCB SAR II A/LUse of a Potential Rabbit Model for Structure-Behavioral Activity Studies of CannabinoidsdV'' Marihuana213218David R. ComptonPatrick J. Little and Billy R. MartinCB SAR II A/LCannabinoid Behaviors: Specific Versus Nonspecific ActionsYK&& {12371247Soren Brogger ChristensenCB SAR II A/LDe euforiserende forbindelser i Cannabis sativa L. Syntese samt struktur i relation til biologisk aktivitetArchiv for Pharmaci OG Chemi6(((  y7180Michel BinderHabib Edery and Gila PorathCB SAR II A/LDelta-7-Tetrahydrocannabinol, A Non-Psychotropic Cannabinoid: Structure-Activity Considerations in the Cannabinoid SeriesMarihuana Biological Effects: Analyses Metabolism, Cellular Responses, Re. 1. production and BrainG.G. Nahas and W.D. M. PatonPerganson PressOxfordOI:A3  yJ. of Pharmacology and Experimentall Therapeutics2358791Sumner BursteinSheila A. Hunter and Lori RenzulliCB SAR II A/LProstaglandis and Cannabis XIV. Tolerance to the Stimulatory Actions of Cannabinoids on Arachidonate Metabolism.~pNN?=;8 > =#]J. Med. Chem2514471450G.R. HandrickR.P. Duffley G. Lambert, J.G. Murphy, H.C. Dalzell, J.F. Howes, R.K. 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DeweyCB SAR II A/LHashish: Synthesis and Central Nervous System Activity of Some Novel Analogues of Cannabidiol and Oxepin Derivatives of Delta-9-Tetrahydrocannabinol88888,, 101220M. Ross JohnsonGeorge M. Milne, Jr.CB SAR II A/LChapter 2. Narcotic Antagonists and AnalgesicsAnnual Reports in Medicinal ChemistryRichard V. HeinzelmanAcademic PressNew York and Londonȵm>0  }J. Clin Pharmacol21320S326SAdesh K. Jain, M.D.Jerome R. Ryan, M.D. F. Gilbert McMahon, MD and Gladys Smith, LPNCB SAR II A/LEvaluation of Intramuscular Levonantradol and Placebo in Acute Postoperative PainՄv55" The J. of Pharmacology and Experimental Therapeuti24710461051Patrick J. LittleDavid R. Compton, M. Ross Johnson, Lawrence S. Melvin and Billy R. MartinCB SAR II A/LPharmacology and Stereoselectivity of Structurally Novel Cannabinoids in MiceUUD@<9 Pharmacology11311Leo E. HollisterCB SAR II A/LStructure-Activity Relationships in Man of Cannabis Constituents, and Homologs and Metabolites of Delta-9-Tetrahydrocannabinol6((( J. of Medicinal Chemistry17287293Shlomo HouryRaphael MechoulamCB SAR II A/LBenzoxocin and Benzoxonin Derivatives. Novel Groups of Terpenophenols with Central Nervous System ActivitySE44(%"  Pharmacology11311Leo E. HollisterCB SAR II A/LStructure-Activity Relationships in Man of Cannabis Constitutents, and Homologs and Metabolites of Delta-9 Tetrahydrocannabinol6((( CB SAR II A/LAnnual Reports in Medicinal Chemistry Volume 10Richard V. HeinzelmanAcademic PressNew York and LondonzgYD !zPsychopharmacology92505507L.E. HolisterH.K. Gillespie, R. Mechoulam and M. SrebnikCB SAR II A/LHuman pharmacology of 1S and 1R enantiomers of delta-3-tetrahydrocannabinolgY..! t> IdyvcLife Science29565574Billy R. MartinRobert L. Balster, Raj K. Razdan, Louis S. Harris and William L. DeweyCB SAR II M/ZBehavioral Comparisons of the Stereoisomers of Tetrahydrocannabinols~p** Life Sciences3615231530Billy R. MartinCB SAR II M/ZStructural Requirements for Cannabinoid-Induced Antinociceptive Activity in Mice;--- 1197189Harry G. ParsRaj K. Razdan, John F. HowesCB SAR II M/ZPotential Therapeutic Agents Derived from the Cannabinoid NucleusAdvances in Drug ResearchN.J. Harper and A.B. SimmonsAcademic PressLondonɻE7  }J. of Medicinal Chemistry1712341235B. LoevB. Dienel, M.M. Goodman, and H. Van HoevenCB SAR II A/LSynthesis of a Norcannabinoidi[11*&"  Clinical Pharmacology and Therapeutics15380386Louis Lemberger, Ph.D.Robert McMahon, Robert Archer, Ken Matsumoto and Howard RoweCB SAR II A/LPharmacologic effects and physiologic disposition of delta 6a10a dimethyl heptyl tetrahydrocannabinol (DMHP) in manKK52/- J. Med. Chem.26278280Cheuk-Man LeeHarold E. Zaugg, Raymond J. Michaels, Anthony T. Dren, Nicholas P. Plotnikoff and Patrick R. YoungCB SAR II A/LNew Azacannabinoids Highly Active in the Central Nervous Systemؙ)) J. of Medicinal Chemistry1612001206Bernard LoevPaul E. Bender, Frederick Dowalo, Edward Macko and Philip J. FowlerCB SAR II A/LCannabinoids. Structure-Activity Studies Related to 1,2-Dimethylheptyl Derivativesڇy66*&"  Pharmacology Biochemistry & Behavior32661666Patrick J. LittleDavid R. Compton, Raphael Mechoulam and Billy R. MartinCB SAR II A/LStereochemical Effects of 11-OH-Delta-8-THC-Dimethylheptyl in Mice and Dogsԉ{DD30-+ Pharmacology9115126I.G. KarniolE.A. CarliniCB SAR II A/LComparative Studies in Man and in Laboratory Animals on Delta-8-and Delta-9-trans-Tetrahydrocannabinol@2&& 8>RJ. Med. Chem2310681072R. MechoulamN. Lander, T.H. Varkony, I. Kimmel, O. Becker, Z.Ben-Zvi, H. Edery and G. PorathCB SAR II M/ZStereochemical Requirements for Cannabinoid Activityy)) J. Medicinal Chemistry2017024Ken MatsumotoPaul Stark and Robert G. MeisterCB SAR II M/ZCannabinoids. 1. 1-Amino- and 1-Mercapto-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyrans_Q11$" J. of Medicinal Chemistry202529Ken MatsumotoPaul Stark and Robert G. MeisterCB SAR II M/ZCannabinoids. 2. Synthesis and Central Nervous System Activities of Some B-Ring Homocannabinoid Derivatives and Related LactonesaS33&$"  523544Billy R. MartinLouis S. HarrisCB SAR II M/ZPharmacological Activity of Delta-9-THC Metabolites and Analogs of CBD, Delta-8-THC and Delta-9-THCThe Cannabinoids: Chemical Pharmacologic, and Therapeutic AspectsS. Agunell, W. L. Dewey and R.E. WilleteAcademic PressOrlando, FLݜ9+  y4269285Y.C. MartinCB SAR II M/ZExamples of the role of computers in new compound design in a pharmaceutical companyStrategy in Drug ResearchJ. A. Keverling BuismanElsevier Scientific Publishing CompanyAmsterdam - Oxford - New Yorkѫ{'  }~Life Sciences29565574Billy R. MartinRobert L. Balster, Raj K. Razdan, Louis S. Harris and William L. 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Bull33392395Shizuo NarimatsuKazuhko Matsubara, Tatsuyuki Shimonishi, Kazuhito Watanabe, Ikuo Yamamoto, and Hidetoshi YoshimuraCB SAR II M/ZPharmacological Activities in the Mouse of Delta-9-Tetrahydrocannabinol Metabolites Oxidized at the 8-Position00  CB SAR II M/ZAnalysis, Metabolism, Cellular Responses, Reproduction and BrainMarihuana Biological EffectsGabriel G. Nahas and Sir William D. M. PattonPergamon PressOxford, New York, Toronto, Sydney, Paris FrankfurtެqU !~101134Raphael MechoulamHabib EderyCB SAR II M/ZStructure-Activity Relationships in Cannabinoid SeriesMarihuana, Chemistry, Pharmacology, Metabolism, and Clinical EffectsR. MechoulamAcademic PressNew York˽m7)  yThe J. of Pharmacology & Experimental Therapeutics219363369Hugh M. McIlhennyRichard W. Mast, M. Ross Johnson and George M. MilneCB SAR II M/ZNatradol Hydrochloride: Pharmacokinetics and Behavioral Effects after Acute and Chronic TreatmentSSB?<9 J. Med. Chem.3310371043Raphael MechoulamAviva Breuer, Tobjorn U.C. 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Pitt and Patricia ReggioSARSynthesis of Rotationally Restricted Tetrahydrocannabinol Ethers\Y)) 4Molecular Pharmacoloty38854862P. H. ReggioH.H. Seltzman, D.R. Compton, W.R. Prescott, Jr., and B.R. MartinSARInvestigation of the Role of the Phenolic Hydroxyl in Cannabinoid Activitytq11%" 3J. Medicinal Chemistry3216301635Patricia H. ReggioKaylar V. Greer, and Stephanie M. CoxSARThe Importance of the Orientation of the C9 Substituent to Cannabinoid Activitya^99'# 2Drug and Alcohol Dependence31219227Billy R. MartinGuy Cabral, Steven R. Childers, Sam Deadwyler, Raphael Mechoulam and Patricia ReggioSARInternational Cannabis Research Society Meeting Summary, Keystone, CO (June 19-20, 1992)萍99*'$" 4>5<MTunQNBResearch Commu. Substances of Abuse113947Kazuhito WatanabeFumiaki Tanabe, Tatsuro Tanaka, Ikuo Yamamoto and Hidetoshi YoshimuraSARPharmacological Activity of Delta-8-Tetrahydrocannabinol Derivatives Oxidized at the 4'-Position in MiceAA0.,* AJ. Pharmacology and Experimental Therapeutics255624630Brian F. ThomasDavid R. Compton and Billy R. MartinSARCharacterization of the Lipophilicity of Natural and Synthetic Analogs of Delta-9-Tetrahydrocannabinol and Its Relationship to Pharmacological Potency1. spLL=:74 @J. Org. Chem.5454285430Craig SiegelPatrick M. Gordon, and Raj K. RazdanSARAn Optically Active Terpenic Synthon for Delta-9-Cannabinoids: Synthesis of (1)-11-Hydroxy-Delta-9-tetrahydrocannabinol (THC) and Its 1',1'-Dimethylheptyl AnalogueQN** ?J. Chem. Soc. Perkin Trans128812886Morris SrebnikNaphtali Lander, Aviva Breuer and Raphael MechoulamSARBase-catalysed Double-bond Isomerizations of Cannabinoids: Structural and Stereochemical Aspectsnk88*&"! >Chem. Pharm. Bull3823172319Kazuhito WatanabeTakako Kijima, Shizuo Narimatsu, Jun Nishkami, Ikuo Yamamoto and Hidetoshi YoshimuraSARComparison of Pharmacological Effect of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites芇33" =Synthetuc Organic Chemistry851854Craig SiegelPatrick M. Gordon, Raj RazdanSARStudies on the Synthesis of (-)-11-Nor9-carboxy-Delta-9-Tetrahydrocannabinol (THC) and Related Compounds: An Improved Oxidative ProcedureTQ44(%"" {<J. Organic Chemistry5668656872Craig SiegelPatrick M. Gordon, David B. Uliss, G. Richard Handrick, Haldean C. Dalzell and Raj K. RazdanSARSynthesis of Racemic and Optically Active Delta-9-Tetrahydrocannabinol (THC) Metabolites萍11%! ;J. of Neurotrauma10109119Esther ShohamiMark Novikov and Raphel MechoulamSARA Nonpsychotropic Cannabinoid, HU-211, Has Cerebroprotective Effects After Closed Head Injury in the RatRO..  >CsJDevelopmental Brain Research767578Colleen R. McLaughlinMary E. AboodCB RECEPTOR A-KDevelopmental expression of cannabinoid receptor mRNA\K>>)'%# IPharmacology Biochemistry and Behavior46575579Mary E. AboodChristine Sauss, Fang Fan, Coril L. Tilton and Billy R. MartinCB RECEPTOR A-KDevelopment of Behavioral Tolerance to Delta-9-THC Withoug Alteration of Cannabinoid Receptor Binding or mRNA Levels in Whole BrainBB52/- HDrug and Alcohol Dependence362731Colleen R. McLaughlinBilly R. Martin, David R. Compton and E. AbbodCB RECEPTOR A-KCannabinoid receptors in developing rats: detection of mRNA and receptor binding|k==(&$" GJ. of Neurochemistry5717691773Michelle Bidaut-RussellAllyn C. HowlettCB RECEPTOR A-KCannabinoid Receptor-Regulated Cyclic AMP Accumulation in the Rat Striatum]L<<%! FJ. of Neurochemistry552126Michelle Bidaut-RussellWilliam A. Devane and Allyn C. HowlettCB RECEPTOR A-KCannabinoid Receptors and Modulation of Cyclic AMP Accumulation in the Rat Braino^88! EJ. Neurochem61S206E. Rodriguez de FonsecaM. Cebeira, J.A. Ramos, M.L. Hernandez, J. Romero and J.J. Fernandez-RuizSARBrain Cannabinoid Receptors and Sex SteroidsMadrid Spain|y00 oGDJ. Pharmacology and Experimental Therapeutics27013341339Weigang ZhuCatherine Newton, Yehia Daaka, Herman Friedman and Thomas W. KleinSARDelta-9-Tetrahydrocannabinol Enhances the Secretion of Interleukin 1 from Endotoxin-Stimulated Macrophages1.JJ?;74 CJ. Med. Chemistry22879882Raymond S. WilsonB.R. Martin and W.L. DeweySARSome 11-Substituted Tetrahydrocannabinols. Synthesis and Comparison with the Potent Cannabinoid Metabolites 11-HydroxytetrahydrocannabinolsNK11  >QJ. Neurochem6217731782Mary A. PachecoSusan J. Ward, and Steven R. ChildersCB RECEPTOR A-KDifferential Requirements of Sodium for Coupling of Cannabinoid Receptors to Adenylyl Cyclase in Rat Brain MembranesbQ,, PJ. Cellular BiochemistryS18C1616Gautam ChaudhuriEmmanuel S. OnaiveCB RECEPTOR A-KCharacterization of the Transcriptional Initiation Sites of the Brain-Type and the Peripheral-Type Human Cannabinoid Receptor GenesZI77'%# OBr. J. Pharmacol106231232M.P. CaulfieldD.A. BrownCB RECEPTOR A-KCannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a Pertussis toxin-sensitive mechanismI8..  NBiochemical and biophysical research communication176492497Sumner H. BursteinCharlene A. Audette, Avgui Charalambous, Sharon A. Doyle, Yan Guo, Sheila A. Hunter and Alexandros MakriyannisCB RECEPTOR A-KDetection of Cannabinoid Receptors by Photoaffinity LabellingTTB?<9 MEur. J. Biochem214173180Monsif BouaboulaMurielle Rinaldi, Pierre Carayon, Christine Carillon, Bruno Delpech, David Shire, Gerard Le Fur and Pierre CasellasCB RECEPTOR A-KCannabinoid-receptor expression in human leukocytes波// LJ. Biological Chemistry2701397313980Monsif BouaboulaBernard Bourrie, Murielle Rinaldi-Carmona, David ShireCB RECEPTOR A-KStimulation of Cannabinoid Receptor CB1 Induces krox-24 Expression in Human Astrocytoma Cells߂q;;+&! KDevelopmental Brain Research81147150A. BonninR. de Miguel, J.C. Rodriguez-Manzaneque, J.J. Fernandex Ruiz, A. Santos, J.A. RamosCB RECEPTOR A-KChanges in tyrosine hydroxylase gene expression in mesencephalic catecholaminergic neurons of immature and adult male rats perinatally exposed to cannabinoids6666644+(%# > XH2X8ZDrug Abuse III643Patricia F. OsgoodHarry G. ParsCB SARII M-ZStructure Activity Relationships in Analogs of Delta-9-Tetrahydrocannabinol: Tachycardia vs AnalgesiaC7** kY105120Mark SegalCB ANALGESIACannabinoids and AnalgesiaCannabinoids as Therapeutic AgentsR. MechoulamCRC PressBoca Raton, FLtk_=#  y~XPsychopharmacologia40217Torbjorn U.C. JarbeBengt G. HenrikssonSARDiscriminative Response Control Produced with Hashish, Tetrahydrocannabinols (Delta-8-THC and Delta-9-THC), and Other DrugsHE22 WJ. Medicinal Chemistry3520652069William A. DevaneAviva Breuer, Tzviel Sheskin, Torbjor U.C. Jarbe, Moris S. Eisen and Raphael MechoulamCB RECEPTOR A-KA Novel Probe for the Cannabinoid Receptorɟ88'# VReceptors and Channels1121134Sam A. DeadwylerRobert E. Hampson, Barbara A. Bennett, Thomas A. Edwards, Jian Mu, Mary A. Pacheco, Susan J. Ward and Steven R. ChildersCB RECEPTOR A-KCannabinoids Modulate Potassium Current in Cultured Hippocampal Neurons44$! UPharmacology Biochemistry & Behavior40503507A. CharalambousG. Marciniak, C.Y. Shiue, S.L. Dewey, D.J. Schlyer, A.P. Wolf and A. MakriyannisCB RECEPTOR A-KPET Studies in the Primate Brain and Biodistribution in Mice Using ( - )-5'-18F-Delta-8-THCBB30-+ TJ. Med. Chem3530763079Communications to the EditorCB RECEPTOR A-K5'-Azido-Delta-8-THC: A Novel Photoaffinity Label for the Cannabinoid ReceptorJ999 SThe FASEB Journal6M.C. ChangH. Schuel, D. Berkery, R. Schuel, S.G. Laychock, A.M. Zimmerman and S. ZimmermanCB RECEPTOR A-KEvidence for a Cannabinoid Receptor in Sperms## gRJ. Pharmacology and Experimental Therapeutics265218226David R. ComptonKenner C. Rice, Brian R. de Costa, Raj K. Razdan, Lawrence S. Melvin, M. Ross Johnson and Billy R. MartinCB RECEPTOR A-KCannabinoid Structure-Activity Relationships: Correlation of Receptor Bining and in Vivo Activities+++++ǶMM=:74 >0V=bMolecular Pharmacology48443450Christian C. FelderKelly E. Joyce, Eileen M. Briley, Jaleh Mansouri, Ken Mackie, Olivier Blond, Yvonne Lai, Alice L. Ma and Richard L. MitchellCB RECEPTOR A-K/CB SARComparison of the Pharmacology and Signal Transducion of the Human Cannabinoid CB1 and CB2 Receptors00000̴88%" aNucleic Acids Research187142C. GerardC. Mollereau, G. Vassart and M. ParmentierCB RECEPTOR A-KNucleotide sequence of a human cannabinoid receptor cDNAgV,,## o`J. Neurochemistry58780782David M. EvansM. Ross Johnson and Allyn C. HowlettCB RECEPTOR A-KCa2+-Dependent Release from Rat Brain of Cannabinoid Receptor Binding ActivitycR..  _Biochemical Pharmacology4812311243Denise A. Dove PettitVincent M. Showalter, Mary E. Abood and Guy A. CabralCB RECEPTOR A-KExpression of a Cannabinoid Receptor in Baculovirus-infected insect Cells̈́s>>)%! ^J. of Pharmacology & Experimental Therapeutics24411571163Jill A. DillAllyn C. HowlettCB RECEPTOR A-KRegulation of Adenylate Cyclase by Chronic Exposure to Cannabimimetic Drugsm\LL@<85 ]141146W. A. DevaneA.C. Howlett, M.R. Johnson, and L.S. MelvinCB RECEPTOR A-KNonclassical Cannabinoid Analgetics inhibit neuronal Adenylate Cyclase and Bind to a Receptor Site in BrainMarijuanaUD  y\J. Neurochemistry4619291935William A. DevaneJames W. Spain, Carmine J. Coscia and Allyn C. HowlettCB RECEPTOR A-KAn Assessment of the Role of Opioid Receptors in the Response to Cannabimimetic Drugszi33" [Molecular Pharmacology34605613William A. DevaneFrancis A. Dysarz III, M. Ross Johnson, Lawrence S. Melvin and Allyn C. HowlettCB RECEPTOR A-KDetermination and Characterization of a Cannabinoid Receptor in Rat Brainߖ66%" }>iNeuroscience11563583Miles HerkenhamAllison B. Lynn, M. Ross Johnson, Lawrence S. Melvin, Brian R. de Costa, and Kenner C. RiceCB RECEPTOR A-KCharacterization and Localization of Cannabinoid Receptors in Rat Brain: A Quantitative in vitro Autoradiographic Study** hBrain Research547267274Miles HerkenhamAllison B. Lynn, Brian R. de Costa and Erick K. RichfieldCB RECEPTOR A-KNeuronal localization of cannabinoid receptors in the basal gangla of the ratwf-- gPharmacology and Experimental Therapeutics26816121623Allison B. LynnMiles HerkenhamCB RECEPTOR A-KLocalization of Cannabinoid Receptors and Nonsaturable High-Density Cannabinoid Binding Sites in Peripheral Tissues of the Rat: Implications for Receptor-Mediate Immune Modulation by Cannabinoids/////kZKK<841 fNeuroscience63637652T.M. WestlakeA.C. Howlett, T.I. Bonner, L.A. Matsuda and M. HerkenhamCB RECEPTOR A-KCannabinoid Receptor Binding and Messerger RNA Expression in Human Brain: An in vitro Receptor Autoradiography and in situ Hybridization Historochemistry study of normal aged and Alzheimer's Brains77777q`(( eNeuro Report6241244Michelle GlassMichael DragunowCB RECEPTOR A-KInduction of the Krox 24 transcription factor in striosomes by a cannabinoid agonistI8(( dBiochem J.279129134Catherine M. GerardCatherine Mollereau, Gilbert Vassart and Marck ParmentierCB RECEPTOR A-KMolecular cloning of a human cannabinoid receptor which is also expressed in testiswf-- cBioorganic & Medicinal Chemistry Letters6189194Yves GareauClaude Dufresne, Michel Gallant, Chantal Rochette, Nicole Sawyer, Deborah M. Slipetz, Nathalie Tremblay, Philip K. Weech, Kathleen M. Metters and Marc LabelleCB RECEPTOR A-KStructure Activity Relationships of Tetrahydrocannabinol Analogues on Human Cannabinoid ReceptorsQQQQQAA630/ 0> 3zgLrTips11395397Allyn C. HowlettCB RECEPTOR A-KReverse pharmacology applied to the cannabinoid receptorlllll4###  qMolecular Pharmacology26532538Allyn C. HowlettRichard M. FlemingCB RECEPTOR A-KCannabinoid Inhibition of Adenylate Cyclse Pharmacology of the Response in Neuroblastoma Cell MembranesXG55%" pMolecular Pharmacology29307313Allyn C. HowlettJames M. Qualy and Leili L. KhachatrianCB RECEPTOR A-KInvolvement of Gi in the Inhibition of Adenylate Cyclase by Cannabimimetic Drugsm\55%" oBrain Research\544145149Tracy M. WestlakeAllyn C. Howlett, Syed F. Ali, Merle G. Paule, Andrew C. Scallet and William Slikker Jr.CB RECEPTOR A-KChronic exposure to Delta-9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors00 nNeuropharmcology26507512A.C. HowlettCB RECEPTOR A-KCannabinoid Inhibition of Adenylate Cyclase: Relative Activity of Constituents and Metabolites of Marihuana<+++ mBrain Research552301310M. HerkenhamB.G.S. Grown, A.B. Lynn, B.R. De Costa and E.K. RichfieldCB RECEPTOR A-KNeuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellumtc** lBrain Research616293302Angelica OviedoJohn Glowa and Miles HerkenhamCB RECEPTOR A-KChronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study\K-- kThe New Biologist3880885Margaret R. HoeheLuciana Caenazzo, Maria M. Martinez, Wang-Ting Hsieh, William S. Modi, Elliot S. Gershown, Tom I. BonnerCB RECEPTOR A-KGenetic and Physical Mapping of the Human Cannabinoid Receptor Gene to Chromosome 6q14-q1500 jProc. Natl. Acad. Sci8719321936Miles HerkenhamAllison B. Lynn, Mark D. Little, M. Ross Johnson, Lawrence S. Melvin, Brian R. de Costa, and Kenner C. RiceCB RECEPTOR A-KCannabinoid receptor localization in brain۱55&" )> 2E{Biochemical Society Transactions23418SRobert A. HirstDavid G. LambertCB RECEPTOR A-KDo SH-SY5Y Human Neuroblastoma Cells Express Cannabinoid Receptors?]L<<--)' ozPharmacology Biochemistry & Behavior40565569Allyn C. HowlettTracy M. Champion-Dorow, Lori L. McMahon and Tracy M. WestlakeCB RECEPTOR A-KThe Cannabinoid Receptor: Biochemical and Cellular Properties in Neuroblastoma Cells璁CC30-+ yMolecular Pharmacology431722Devin B. HoustonAllyn C. HowlettCB RECEPTOR A-K/COUPLINGSolubilization of the Cannabinoid Receptor from Rat Brain and Its Functional Interaction with Guanine Nucleotide-Binding Proteins]C33#! xMolecular Pharmacology33297302Allyn C. HowlettM. Ross Johnson, Lawrence S. Melvin and George M. MilneCB RECEPTOR A-KNonclassical Cannabinoid Analgetics Inhibit Adenylate Cyclase: Development of a Cannabinoid Receptor Model}l55%" wTins13420423Allyn C. HowlettMichelle Bidaut-Russell, William A. Devane, Lawrence S. Melvin, M.Ross Johnson and Miles HerkenhamCB RECEPTOR A-KThe cannabinoid receptor: biochemical, anatomical and behavioral characterization薅##  vMolecular Pharmacology27429436Allyn C. HowlettCB RECEPTOR A-KCannabinoid Inhibition of Adenylate Cyclase Biochemistry of the Response in Neuroblastoma Cell MembranesF555%" uLife Sciences3518031810Allyn C. HowlettCB RECEPTOR A-KInhibition of Neuroblastoma Adenylate Cyclase by Cannabinoid and Nantradol Compounds?... tBiochemical Pharmacology3832973304Allyn C. HowlettDonald K. Scott and Geral H. WilkenCB RECEPTOR A-KRegulation of Adenylate Cyclase by Cannabinoid Drugs Insights Based on Thermodynamic Studiesm\99)%! s148156Allyn C. HowlettCB RECEPTOR A-KRegulation of Adenylate Cyclase in a Cultured Neuronal Cell Line by Marijuana Constituents, Metabolites of Delta-9-tetrahydrocannabinol, and Synthetic Analogs Having Psychoactivity.  y> K,a^|9J. American Chemical Society15861587E. J. CoreyHaruki Niwa, J.R. FalckANANDAMIDESelective Epoxidation of Eicosa-cis-5,8,11,14-tetraenoic (Arachidonic) Acid and Elcosa-cis-8,11,14-trienoic AcidWM66+'## {Proc. Natl. Acad. Sci.8035813584E. J. CoreyChuan Shih, and John R. CashmanANANDAMIDEDocosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis[Q22'# Tetrahedron Letters243740E. J. CoreySadahiko Iguchi, John O. Albright and Biswanath DeANANDAMIDEStudies on the Conformational Mobility of Arachidonic Acid. Facile Macrolactonization of 20-Hydroxyarachidonic Acidg]++  Biochemical Pharmacology47711715Steven R. ChildersTammy Sexton and Mary Beth RoyANANDAMIDEEffects of Anandamide on Cannabinoid Receptors in Rat Brain MembranesaW99'$! FEBS359133136Markus WartmannDebra Campbell, Asha Subramanian, Sumner H. Burstein, Roger J. DavisANANDAMIDEThe MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamideqg##  Biochemical and Biophysical Research Communication197740746Lester M. BornheimKelly Y. Kim, Baili Chen and M. Almira CorreiaANANDAMIDEThe Effect of Cannabidiol on Mouse Hepatic Microsomal Cytochrome P450-Dependent Anandamide MetabolismTTB?<9 ~Biochemical Pharmacology50677686Lester M. BornheimKelly Y. Kim, Baili Chen and M. Almira CorreiaANANDAMIDEMicrosomal Cytochrome P450-Mediated Liver and Brain Anandamide Metabolismqg99'$! }Pharmacology and Experimental Therapeutics27311721181Irma B. AdamsWilliam Ryan, Michael Singer, Brian F. Thomas, David R. Compton, Raj K. Razdan and Billy R. MartinANANDAMIDEEvaluation of Cannabinoid Receptor Binding and in Vivo Activities for Anandamide Analogs II<841 |Biochimica et Biophysica Acta1220163170Cecilia J. HillardJohn A. AuchampachCB RECEPTOR A-KIn vitro activation of brain protein kinase C by the cannabinoidscR@@.+($  >lmhf%Proc. Natl. Acad. Sci.9076567660Christian C. FelderEileen M. Briley, Julius Axelrod, John T. Simpson, Ken Mackie and William A. DevaneANANDAMIDEAnandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction/////::'# Proc. Natl. Acad. Sci9233763380L. FacciR. Dal Toso, S. Romanello, A Buriani, S.D. Skaper, and A. LeonANANDAMIDEMast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamidevl..&" Pharmacology and Experimental Therapeutics26812711277David M. EvansJ. Thad Lake, M. Ross Johnson and Allyn C. HowlettANANDAMIDE/CB RECEPTOREndogenous Cannabinoid Receptor Binding Activity Released from Rat Brain Slices by Depolarization|JJ<841 Pharmacology Biochemis and Behavior46967972Jacqueline N. CrawleyRebecca L. Corwin, John K. Robinson, Christian C. Felder, William A. Devane and Julius AxelrodANANDAMIDEAnandamide, an Endogenous Ligand of the Cannabinoid Receptor, Induces Hypomotility and Hypothermia In Vivo in Rodents$$$$$GG2/,* Proc. Natl. Acad. Sci.9166986701William A. DevaneJulius AxelrodANANDAMIDEEnzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranesPF88'# Biological Chemistry2691434514348Kelly K. KruszkaRichard W. GrossANANDAMIDEThe ATP- and CoA-independent Synthesis of ArachidonoylethanolamideRH88(# Biological Chemistry2692293722940Bohumir KoutekGlenn D. Prestwich, Allyn C. Howlett, Suzette A. Chin, David Salehani, Nima Akhavan and Dale G. DeutschANANDAMIDE/AEAInhibitors of Arachidonoyl Ethanolamide Hydrolysisެ66(# > !}Angew. Chem.Int. Ed. Engl.3210271029Wolf D. LehmannGerhard FurstenbergerANANDAMIDEBiologically Active Linear Metabolites of Arachidonic Acid- The First Endogenous Ligand of the Cannabinoid ReceptorYO::+'#! Biological Chemistry2691434514348Kelly K. KruszkaRichard W. GrossANANDAMIDEThe ATP-and CoA-independent Synthesis of ArachidonoylethanolamideRH88(# Biomedical Chromatography95657Daisuke KogaTomofumi Santa, Kenichi Hagiwara, Kazuhiro Imai, Hiromasa Takizawa, Tetsuo Nagano, Masaaki Hirobe, Masako Ogawa, Taku Sato and Keizo InoueANANDAMIDEHigh-Performance Liquid Chromatography and Fluorometric Detection of Arachidonylethanolamide (Anandamide) and its Analogues, Derivatized with 4-(N-Chloroformylmethyl-N-Methyl)Amino-7-N,N-Dimethylaminosulphonyl- 2,1,3-Benzoxadiazole (DBD-COCI)Ż11%#!  Prostaglandins Leukotrients & Essential Fatty Acid48429437D. E. JohnsonS. L. Heald, R.D. Dally and R.A. JanisANANDAMIDEIsolation, Identification and Synthesis of an Endogenous Arachidonic Amide that Inhibits Calcium Channel Antagonist 1, 4-Dihydropyridine Binding~tNNA>;9 Biochimica et Biophysica Acta1257249256Cecilia J. HillardDouglas M. Wilkison, Wiliam S. Edgemond, William B. CampbellANANDAMIDECharacterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain|@@.+($ Biochemical Pharmacology50885888Manuel GuzmanJavier Fernandez-Ruiz, Cristina Sanchez, Guillermo Velasco and Jose A. RamosANANDAMIDEEffects of Anandamide on Hepatic Fatty Acid Metabolism44'$! Molecular Pharmacology48288292Josef PrillerEileen M. Briley, Jaleh Mansouri, William A. Devane, Ken Mackie and Christian C. FelderANANDAMIDEMead Ethanolamide, a Novel Eicosanoid, Is an Agonist for the Central (CB1) and Peripheral (CB2) Cannabinoid Receptors22%" >EmMed. Chem3630323034Lumir HanusAsher Gopher, Shlomo Almong and Raphael MechoulamANANDAMIDETwo New Unsaturated Fatty Acid Ethanolamides in Brain That Bind to the Cannabinoid Receptor`V%% European Journal of Pharmacology231313314Ester FrideRaphael MechoulamANANDAMIDEPharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituentVL;;0-*' Molecular Pharmacology44498503Ken MackieWilliam Devane and Bertil HilleANANDAMIDEAnandamide, an Endogenous Cannabinoid, Inhibits Calcium Current as a Partial Agonist in N18 Neuroblastoma CellsXN//%" Med. Chem3630323034Lumir HanusAsher GopherANANDAMIDETwo New Unsaturated Fatty Acid Ethanolamides in Brain That Bind to the Cannabinoid Receptor;1%% Pharmacology and Experimental Therapeutics270219227Peter B. SmithDavid R. Compton, Sandra P. Welch, Raj K. Razdan, Raphael Mechoulam and Billy R. MartinANANDAMIDEThe Pharmacological Activity of Anandamide, a Putative Endogenous Cannabinoid, in MiceHH:741 European Journal of Pharmacology278279283Karoly VargaKristy Lake, Billy R. Martin, George KunosANANDAMIDENovel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamidepf<<0-*' Med. Chem3718891893Vasiliki AbadjiSonyuan Lin, Gihan Taha, Graeme Griffin, Lesley A. Stevenson, Roger G. Pertwee, and Alexandros MakriyannisANANDAMIDE/AEA(R)-Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability)) Chem. Soc. Perkin Trans.220912094Jean-Yves Le QuestelChristian Laurence, Abdeljalil Lachkar, Maryvonne Helbert and Michel BerthelotANANDAMIDE/GPCR INTERACTIONSHydrogen-bond Basicity of Secondary and Tertiary Amides, Carbamates, Ureas and Lactams<<($  > Molecular Pharmacology48288292Josef PrillerEileen M. Briley, Jaleh Mansouri, William A. Devane, Ken Mackie and Christian C. FelderANANDAMIDEMead Ethanolamide, a Novel Eicosanoid, Is an Agonist for the Central (CB1) and Peripheral (CB2) Cannabinoid Receptors22%" Proc. Natl. Acad. Sci.9176787682Herbert SchuelElaine Goldstein, Raphael Mechoulam, Arthur M. ZimmermanANANDAMIDEAnandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibitin the acrosome reactionwm55'# Br. J. Pharmacol11014831490R.G. PertweeL.A. Stevenson and G. GriffinANANDAMIDECross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamideUK.." European Journal of Pharmacology2727378Roger G. PertweeSusanthi R. Fernando, Graeme Griffin, Vasiliki Abadji, Alexandros MakriyannisANANDAMIDEEffect of phenylmethyssulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations22222>>.,*' Pharmacology and Experimental Therapeutics272699707E. FrideJ. Barg, R. Levy, D. Saya, E. Heldman, R. Mechoulam and Z. VogelANANDAMIDELow Doses of Anandamides Inhibit Pharmacological Effects of Delta-9-Tetrahydrocannabinol䌂BB:741 Neurochemistry61352355Zvi VogelJacob Barg, Rivka Levy, Danielle Saya, Eliahu Heldman and Raphael MechoulamANANDAMIDEAnandamide, a Brain Endogenous Compound, Interacts Specifically with Cannabinoid Receptors and Inhibits Adenylate Cyclase{q&& Neuroendocrinology59110112Joseph WeidenfeldShaul Feldman, Raphael MechoulamANANDAMIDEEffect of the Brain Constitutent Anandamide, a Cannabinoid Receptor Agonist, on the Hypothalamo-Pituitary-Adrenal Axis in the Rat\R22! >Neuroendocrinol. Lett.16297303Tibor WengerGerassunis Fragakis, Kimonas Probonas, Bela E. Toth & Nikolaos YiannakakisANANDAMIDEAnandamide (endogen cannabinoid) Affects Anterior Pituitary Hormone Secretion in Adult Male Rat{11%" Neuroimmunology55197115Herbert SchwarzFrancisco J. Blanco, Martin LotzANANDAMIDEAnadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces aoptosisWM-- Proc. Natl. Acad. Sci9176787682Herbert SchuelElaine Goldstein, Raphael Mechoulam, Arthur M. Zimmerman and Selma ZimmermanANANDAMIDEAnandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction+++++44&" Molecular Pharmacology46516522Julia C. PintoFrederike Potie, Kenner C. Rice, Daniel Boring, M. Ross Johnson, David M. Evans, Gerald H. Wilden, Catherine H. Cantrell and Allyn C. HowlettANANDAMIDE/CB RECEPTORCannabinoid Receptor Binding and Agonist Activity of Amides and Esters of Arachidonic Acid0000033%" Med. Chem3718891893Vasiliki AbadjiSonyuan Lin, Gihan Taha, Graeme Griffin, Lesley A. Stevenson, Roger G. Pertwee and Alexandros MakriyannisANANDAMIDE(R)-Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability)) European Journal of Pharmacology250205208Andrew P. WickenRoger G. PertweeANANDAMIDEDelta-9-Tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of ratsZP@@0-*' Neuroendocrinol. Lett.16159164J. RomeroL. Garcia, J. A. Ramos and J.J. Fernandex-RuizANANDAMIDEThe Putative Cannabinoid Receptor Ligand, Anandamide, Stimulates Hypothalamic Tyrosine Hydroxylase Activity and Inhibits Prolactin Releasef\..%" 6> =PEuropean Journal of Pharmacology Molecular Pharmac267R1R3Pierre MailleuxJean-Jacques VaderhaeghenCB RECEPTOR L-ZDelta-9-Tetrahydrocannabinol regulates substance P and enkephalin mRNAs levels in the caudate-putamenwhOO@><9 European Journal of Pharmacology266193196Pierre MailleuxJean-Jacques VanderhaeghenCB RECEPTOR L-ZGlutamatergic regulation of cannabinoid receptor gene expression in the caudate-putamenhY??0-*' Molecular and Cellular Biochemistry121119126Ruishen LuJohn R. Hubbard, Billy R. Martin and Mohammed Y. KalimiCB RECEPTOR L-ZRoles of sulfhydryl and disulfide groups in the binding of CP-55,940 to rat brain cannabinoid receptort==30-* J. Pharmacol. Exp. Therapeutics24710461051Patrick J. LittleDavid R. Compton, M. Ross Johnson, Lawrence S. Melvin and Billy R. 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RazdanANANDAMIDECharacterization of Anandamide- and Fluoroanandamide-Induced Antinociception and Cross-Tolerance to Delta-9-THC after Intrathecal Administration to Mice: Blockade of Delta-9-THC-Induced AntinociceptionPPPPP|KK<841 > Med. Chem.3738673870Yan GuoVasiliki Abadji, Kelly L. Morse, Donna J. Fournier, Xiuyan Li, and Alexandros MakriyannisCB RECEPTOR L-Z(-)-11-Hydroxy-7'-isothiocyanato-1',1'-dimethylheptyl-Delta-8-THC: A Novel, High-Affinity Irreversible Probe for the Cannabinoid Receptor in the Brain!!!!!{"" Neuroscience Letters143200204Pierre MailleuxMarc Parmentier and Jean-Jacques VanderhaeghenCB RECEPTOR L-ZDistribution of cannabinoid receptor messenger RNA in the human brain: an in situ hybridization histochemistry with oligonucleotidespa33$! 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VanderhaghenCB RECEPTOR L-ZDistribution of Neuronal Cannabinoid Receptor in the Adult Rat Brain: A Comparative Receptor Binding Radioautography and in situ Hybridization HistochemistryG8&& Neuroscience Letters1752527Pierre MailleuxXavier Preud'homme, Nicole Albala, Jean-Marie Vanderwinden, Jean Jacques VanderhaeghenCB RECEPTOR L-ZDelta-9-Tetrahydrocannabinol regulates gene expression of the growth factor pleiotrophin in the forebrain11"  > GPharmac.24811824Roger PertweeCB RECEPTOR L-ZThe Evidence for the Existence of Cannabinoid Receptorsjjjjj3$$$ Nature3656165Sean MunroKerrie L. Thomas & Muna Abu-ShaarCB RECEPTOR L-ZMolecular characterization of a peripheral receptor for cannabinoidsN?  Pharmacology and Experimental Therapeutics234784791Jeffrey S. NyeHerbert H. Seltzman, Colin G. Pitt and Solomon H. SnyderCB RECEPTOR L-ZHigh-Affinity Cannabinoid Binding Sites in Brain Membranes Labeled with [3H]-5'-Trimethylammonium Delta-8-Tetrahydrocannabinol HH:741 Pharmacology and Experimental Therapeutics219363369Hugh M. McIlhennyRichard W. Mast, M. Ross Johnson and George M. MilneCB RECEPTOR L-ZNantradol Hydrochloride: Pharmacokinetics and Behavioral Effects after Acute and Chronic TreatmentKK:741 Biochemical Pharmacology4815371544Raphael MechoulamLumir Hanus and Billy R. MartinCB RECEPTOR L-Z/ANANDAMIDESearch for Endogenous Ligands of the Cannabinoid ReceptorsY::)%! CNS Drugs2255260Raphael MechoulamZvi Vogel and Jacob BargCB RECEPTOR L-ZCNS Cannabinoid Receptors Role & Therapeutic Implication for CNS DisordersO@(( Comparative Neurology327535550Lisa A. MatsudaTom I. Bonner, and Stephen J. LolaitCB RECEPTOR L-ZLocalization of Cannabinoid Receptor mRNA in Rat BraingX44%" Nature346561564Lisa A. MatsudaStephen J. Lolait, Michael J. Brownstein, Alice C. Young & Tom I. 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RamosCB RECEPTOR L-ZDownregulation of Rat Brain Cannabinoid Binding Sites After Chronic Delta-9-Tetrahydrocannabinol TreatmentFF/-+) Febs Letter350240244Murielle Rinaldi-CarmonaFrancis Barth, Michael Heaulme, David Shire, Bernard Calandra, Christian Congy, Serge Martinex, Jeanne Muruani, Gervais Neliat, Daniel Caput, Pascual Ferrara, Philippe Soubrie, Jean Claude Breliere, Gerard Le FurCB RECEPTOR L-ZSR141716A, a potent and selective antagonist of the brain cannabinoid receptorddddd33 Current Opinion in Neurobiology4406412Terry ReisineMichael J. BrownsteinCB RECEPTOR L-ZOpioid and cannabinoid receptors~~~~~^O::-*'& Endocrinology107848850Vishnudutt PurohitBalwant S. Ahluwahlia and Robert A. VigerskyCB RECEPTOR L-ZMarihuana Inhibits Dihydrotestosterone Binding to the Androgen Receptorj[// 9>dQBiochemical and Biophysical Research Communication18811111115J. R. ArdenO. Nagata, M.S. Shockley, M. Philip, J. Lameh and Wolfgang SadeeCOUPLINGMutational Analysis of Third Cytoplasmic Loop Domains in G-Protein Coupling of the HM1 Muscarinic ReceptorOOD@<9 Protein Expression and Purification6363370James W. AprilettiJohn D. Baxter, Kenneth H. Lau, and Brian L. WestCOUPLINGExpression of the Rat Alpha-1 Thyroid Hormone Receptor Ligand Binding Domain in Escherichia coli and the Use of a Ligand-Induced Conformation Change as a Method for Its Purification to Homogeneity@@@@@|tCC1.+* Pharmacology Biochemistry and Behavior4910931100George Pugh, Jr.Sandra P. Welch and Pam P. BassCB RECEPTOR L-ZModulation of Free Intracellular Calcium and cAMP by Morphine and Cannabinoids, Alone and in Combination in Mouse Brain and Spinal Cord Synaptosomes ufGG73/- Molecular Pharmacology40656665Brian F. ThomasDavid R. Compton, Billy R. Martin, and Simon F. SemusCB RECEPTOR L-ZModelling the Cannabinoid Receptor: A Three-Dimensional Quantitative Structure-Activity Analysisxi44%" Molecular Pharmacology48352361Deborah M. SlipetzGary P. O'Neill, Leonard Favreau, Clude Dufresne, Michel Gallant, Yves Gareau, Danie Guay, Marc Labelle and Kathleen M. MettersCB RECEPTOR L-ZActivation of the Human Peripheral Cannabinoid Receptor Results in In hibition of Adenylyl Cyclase'''''Ŷ77%" Brain Research57593102Elizabeth M. JansenDean A. Haycock, Susan J. Ward and Virginia S. SeyboldCB RECEPTOR L-ZDistribution of cannabinoid receptors in rat brain determined with aminoalkyindolesvg00 Biologicial Chemistry27037263731David ShireChristine Carillon, Mourad Kaghad, Bernard Calandra, Murielle Rinaldi-Carmona, Gerard Le Fur, Daniel Caput and Pascual FerraraCB RECEPTOR L-ZAn Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing 22'# p> Hv{Molecular Pharmacology49132141Dylan A. BulsecoMichael I. SchimerlikCOUPLINGSingle Amino Acid Substitutions in the pm2 Muscarinic Receptor Alter Receptor/G Protein Couplin Without Changing Physiological ResponsesRJ55%" TIPS17189191Robert F. BrunsCOUPLINGConformational induction versus conformation selection: evidence from allosteric enhancers*"""  J.Cell. BiochemS-18A124Henry R. BourneCOUPLINGHow G. Protein Transmit SignalsTTTTT5--- oNature369611612Henry R. BourneCOUPLINGThe importance of being GTPHHHHH-%%%  FEB258133136Jurgen WessMark R. Brann and Tom I. BonnerCOUPLING/MUTATION R-ZIdentification of a small intracellular region of the muscarinic m3 receptor as a determinant of selective couplin to PI turnoverR=  Nature374272276Richard A. BondPaul Left, T. David Johnson, Carmelo A. Milanos, Howard A. Rockman, Thomas R. McMinn, Subramanian Apparsundaram, Michael F. Hyek Terry P. Kenakin, Lee F. Allen and Robert J. 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TilfordCOUPLINGEndogenous ligands and inverse agonismXXXXX2*  :> p]XTIPS16232239Terry KenakinCOUPLINGAgonist-receptor efficacy II: agonist trafficking of receptor signalsnnnnn(   TIPS16188193Terry KenakinCOUPLINGAgonist-receptor efficacy I: mechanisms of efficacy and receptor promiscuityuuuuu(   TIPS16256258T. KenakinCOUPLINGPharmacological Proteus?=====%  TIPS12371374Mary KeenCOUPLINGTesting models of agonism for G protein coupled receptors]]]]]$  Biological Chemistry2682085120854Inhae JiTae H. JiCOUPLINGReceptor Activation Is Distinct from Hormone Binding in Intact Lutropin-Choriogonadotropin Receptors and Asp397 Is Important for Receptor ActivationA900(# Biological Chemistry2661495314957Inhae JiTae H. JiCOUPLINGAsp 383 in the Second Transmembrane Domain of the Lutropin Receptor Is Important for High Affinity Hormone Binding and cAMPA900(# Trends in Cell Biology3230236Jorge Iniguez-LluhiChristiane Kleuss and Alfred G. 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Vorel, Joyce Lowinson, and Eliot L. GardnerLife Sciences JournalConditioned Place Preference Induced by Delta-9-Tetrahydrocannabinol: Comparison with Cocaine, Morphine, and Food Rewardxc++ "Life Sciences5620652072G.A. CabralD.M. Toney, K. Fischer-Stenger, M.P. Harrison, and F. Marciano-CabralLife Sciences JournalAnandamide Inhibits Macrophage-Mediated Killing of Tumor Necrosis Factor-Sensitive Cellsۃn)) >1Life Sciences5621772184A. BonninR. de Miguel, M.L. Hernandez, J.A. Ramos and J.J. Fernandez RuizLife Sciences JournalThe Prenatal Exposure to delta9-Tetrahydrocannabinol Affects The Gene Expression and The activity of Tyrosine Hydroxylase During Early Brain Development|g'' 0Life Sciences5621692176P. RubioF. Rodriguez de Fonseca, R. M. Munoz, C. Ariznavareeta, J.L. Martin-Calderon and M. NavarroLife Sciences JournalLong-Term Behavioral Effects of Perinatal Exposure to Delta 9-Tetrahydrocannabinol in Rats: Possible Role of Pituitary-Adrenal Axis&& /Life Sciences5621592168P.A. 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PeraltaMUTATION A-PCharged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptorA4##  ZMolecular Pharmacology41695698Xiao-Ming GuanStephen J. Proutka and Brian K. KobilkaMUTATION A-PIdentification of a Single Amino Acid Residue Responsible for the Binding of Class of Beta-Adrenergic Receptor Antagonists to 5-Hydroxytryptamine1a ReceptorsgZ33%" YBiologocal Chemistry2672199121994Sankuratri SuryanarayanaMark von Zastrow, and Brian K. KobilkaMUTATION A-PIdentification of Intramolecular Interactions in Adrenergic Receptorssf@@(# XBiological Chemistry2682085120854Inhae JiTae H. JiMUTATION A-PReceptor Activation Is Distinct from Hormone Binding in Intact Lutropin-Choriogonadotropin Receptors as Asp397 Is Important for Receptor ActivationF900(# WBiological Chemistry2701402414030Yoshiaki YamanoKenji Ohyama, Mitsuhiro Kikyo, Tomoaki Sano, Yoshiko Nakagomi, Yoshihisa Inoue, Norifumi Nakamura, Isao Morishima, Deng-Fu Guo, Takao Hamakubo, and Tadashi InagamiMUTATION A-PMutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1)*7777777(# >dBiological Chemistry2693019530199Ji-Chun XueChongguang Chen, Jinmin Zhu, Satya Kunapuli, J. Kim DeRiel, Lei Yu and Lee-Yuan Liu-ChenMUTATION A-P/MUTATION R-ZDifferential Binding Domains of Peptide and Non-peptide Ligands in the Cloned Rat kappa Opioid Receptor 33(# cBiological Chemistry2701297712979Ji-Chun XueChongguang Chen, Jinmin Zhu, Satya P. Kunapuli, J. 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OprianMUTATION A-P/COUPLINGActivating Muttions of Rhodopsin and Other G Protein-Coupled ReceptorscM==0-*( {Biophysical Chemistry561322Koji NakanishiHongzhi Zhang, Keith A. Lerro, Shin-ichi Takekuma, Toshihiro Yamamoto, Thoai Hung Lien, Lakshmi Sastry, Du-Jon Baeck, Carole Moquin-Pattey, Marcus F. Boehm, Fadila Derguini, Mary Ann GawinowiczMUTATION A-P/LABELINGPhotoaffinity labeling of rhodopsin and bacteriorhodopsin@@@@@00"  >)@`ylcBr. J. Pharmcol113331333Thue W. SchwartzHans T. Schambye, Bjorn v. Wijk, Siv A. Hjorth, Wolfgang Wienen, Michael Entzeroth, Derk J. BergsmaMUTATION R-ZMutations in transmembrane segment VII of the AT1 receptor differentiate between closely related insurmountable and competitive angiotensin antagonists66666// Molecular Pharmacology47425431Thue W. SchwartzHans T. Schambye, Siv A. Hjorth, Joseph WeinstockMUTATION R-ZInteraction betwen the Nonpeptide Angiotensin Antagonist SKF-108,566 and Histidine 256 (HisVI:16) of the Angiotensin Type 1 Receptorsf55%" Investigative Ophthalmology & Visual Science3619341942Michael A. SandbergCarol Weigel-DiFranco, Thaddeus P. Dryja and Eliot L. BersonMUTATION R-ZClinical Expression Correlates With Location of Rhodopsin Mutation in Dominant Retinits PigmentosaPP=953 Molecular Pharmacology46122128Bruce S. SachaisJames E. KrauseMUTATION R-ZBoth Extracellular and Transmembrane Residues Contribute to the Species Selectivity of the Neurokinin-1 Receptor Antagonist WIN 51708QD55%" Biological Chemistry26823192323Bruce S. SachaisR. Michael Snider, John A. Lowe III, and James E. KrauseMUTATION R-ZMolecular Basis for the Species Selectivity of the Substance P Antagonist CP-96,345*{n66&" Biological Chemistry2671931319319Jurgen WessRobert Maggio, John R. Parmer and Zvi VogelMUTATION R-ZRole of Conserved Threonine and Tyrosine Residues in Acetylcholine Binding and Muscarinic Receptor Activationk^33(# Biological Chemistry2691153711541Jurgen WessKlaus Blumi, Ernst MutschlerMUTATION R-Z/CONSTACTICFunctional Role of a Cytoplasmic Aromatic Amino Acid in Muscarinic Receptor-mediated Activation of Phospholipase C*gO33(# Biochemistry3330073013Catherine D. StraderRuey-Ruey C. Huang, Hong Yu, and Tung Ming FongMUTATION A-P/COUPLINGInteraction of Substance P with Second and Seventh Transmembrane Domains of the Neurokinin-1 Receptorv`11 >]F Molecular Pharmacology4110611065Catherine D. StraderAnne H. Cheung, Ruey-Ruey C. HuangMUTATION R-ZInvolvement of Specific Hydrophobic, but not Hydrophilic, Amino Acids in the Third Intracellular Loop of the Beta-Adrenergic Receptor in the Activation of Gsj];;'# Biological Chemistry2631026710271Catherine D. StraderIrving S. Sigal, Mari Rios Candelore, Elaine Rands, Wendy Hill and Richard A. F. DixonMUTATION R-ZConserved Aspartic Acid Residues 79 and 113 of the Beta-Adrenergic Receptor Have Different Roles in Receptor Function<<(# Nature365652654Andrew ShenkerLouisa Laue, Shinji Kosugl, John J. Merendino Jr., Takashi Minegishl and Gordon B. Cutler Jr.MUTATION R-Z/CONSTACTICA constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty$$  Molecular Pharmacology45165170Stuart C. SealfonWei Zhou, Colleen Flanagan, Juan A. Ballesteros, Karel Konvicka, James S. Davison, Harel Weinstein, Robert P. MillarMUTATION R-Z/GPCR Models Q-ZA Reciprocal Mutation Supports Helix 2 and Helix 7 Prosimity in the Gonadotropin-Releasing Hormone Receptor22222Ǫ66%" Biological Chemistry2692263622641Stuart C. SealfonColleen A. Flanagan, Inga I. Becker, James S. Davidson, Ian K. Wakefield, Wei Zhou and Robert P. MillarMUTATION R-ZGlutamate 301 of the Mouse Gonadotropin-releasing Hormone Receptor Confers Speicificity for Arginine 8 of Mammalian Gonadotropin-releasing Hormone?????99(# Proc. Natl. Acad. Sci.9170467050Thue W. SchwartzHans T. Schambye, Siv A. Hjorth, Derk J. Bergsma, Ganesh SatheMUTATION R-ZDifferentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptorsu77'# >><+2&(Nature3267377Catherine D. StraderRichard A.F. Dixon, Irving S. Sigal, Elaine Rands, R. Bruce Register, Mari Rios Candelore, Allan D. BlakeMUTATION R-ZLigand binding to the Beta-adrenergic receptor involves its rhodopsin-like core힑((  Proc. Natl. Acad.Sci8443844388Catherine D. Strader,Irving S. Sigal, R. Bruce Register, Mari Rios Candelore, Elaine Rands and Richard A. F. DixonMUTATION R-ZIdentification of residues required for ligand binding to the Beta-adrenergic receptor::%! Biological Chemistry26927282732Catherine D. StraderTung Ming Fong, Hong Yu, Margaret A. Cascieri, Dennis Underwood, Christopher J. SwainMUTATION R-ZThe Role of Histidine 265 in Antagonist Binding to the Neurokinin-1 Receptor蜏::&" Biological Chemistry2621643916443Catherine D. StraderRichard A. F. Dixon, Anne H. Cheung, Mari Rios Candelore, Allan D. Blake and Irving S. SigalMUTATION R-ZMutations That Uncouple the Beta-Adrenergic Receptor from Gs and Increase Agonist Affinity<<(# Nature362350354Catherine D. StraderTung Ming Fong, Margaret A. Cascieri, Hong Yu, Alka Bansal, Christopher SwainMUTATION R-Z/GPCR INTERACTIONSAmino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345w**  Medicinal Research Reviews14387399Catherine D. StraderTung M. FongMUTATION R-ZFunctional Mapping of the Ligand Binding Sites of G-Protein Coupled ReceptorsVI==)&#! Biochemistry341004810055Catherine D. StraderRuey-Ruey C. Huang, Pasquale P. Vicario and Tung Ming FongMUTATION R-ZIdentification of Residues Involved in Ligand Binding to the Neurokinin-2 Receptorzm33 Biological Chemistry2691495714961Catherine D. StraderTung Ming Fong, Hong Yu, Margaret A. Cascieri, Dennis Underwood, Christopher J. SwainMUTATION R-ZInteraction of Glutamine 165 in the Fourth Transmembrane Segment of the Human Neurokinin-1 Receptor with Quinuclidine Antagonists<<(# >JhyEMBO12331338Jurgen WessSujal Nanavati, Zvi Vogel and Roberto MaggioMUTATION R-ZFunctional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptorWJ  Life Sciences5314471463Jugen WessMUTATION R-ZMutational Analysis of Muscarinic Acetylcholine Receptors: Structural Basis of Ligand/Receptor/G Protein Interactions5((( Biological Chemistry2701953219539Jurgen WessJie Liu, Torsten Schoneberg, Michiel van RheeMUTATION R-ZMutational Analysis of the Relative Orientation of Transmembrane Helices I and VII in G Protein-coupled Receptorsm`33(# Biochemistry3375877593Ellen R. WeissShoji Osawa, Wen Shi and Charlene D. DikersonMUTATION R-ZEffects of Carboxyl-Terminal Truncation on the Stability and G Protein-Coupling Activity of Bovine RhodopsineX++ FASEB228412848Ellen R. WeissDaniel J. Kelleher, Chee Wai Woon, Sidhartha Soparkar, Shoji Osawa, Lynn E. Heasley and Gary L. JohnsonMUTATION R-ZReceptor activation of G proteins##  Computer-Aided Molecular Design3165174H.W. Th. van VlijmenA.P. IJzermanMUTATION R-Z/GPCR Models Q-ZMolecular modeling of a putative antagonist binding site on helix III of the Beta-adrenoceptorkNAA-*'& Biophysical Journal66A59M. SubiradeM. PezoletMUTATION R-ZInfluence of a Lipid-Binding Protein on the Conformation and Orientation of Phospholipid Monolayers Studied by Polarized Attenuated Total Interanal Reflectance Infrared SpectroscopyA4** oBiological Chemistry2641357213578Catherine D. StraderMari Rios Candelore, Wendy S. Hill, Irving S. Sigal, and Richard A. F. DixonMUTATION R-ZIdentification of Two Serine Residues Involved in Agonist Activation of the Beta-Adrenergic Receptor<<(# >`Biological Chemistry2701402414030Yoshiaki YamanoKenji Ohyama, Mitsuhiro Kikyo, Tomoaki Sano, Yoshiko Nakagomi, Yoshihisa Inoue, Norifumi Nakamura, Isao Morishima, Deng-Fu Guo, Takao Hamakubo and Tadashi InagamiMUTATION R-ZMutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1)5555577(# Molecular Pharmacology46470476Misa YamadaMitsuhiko Yamada, Michael A. Watson and Elliott RichelsonMUTATION R-ZDeletion Mutation in the Putative Third Intracellular Loop of the Rat Neurotensin Receptor Abolishes Polyphosphoinositide Hydrolysis but Not Cyclic AMP Formation in CHO-K1 Cells'''''vi00%" Neurochemistry6216641669Robert WoodwardSarah J. Daniell, Philip G. Strange, and Louise H. NaylorMUTATION R-ZStructural Studies on D2 Dopamine Receptors: Mutation of a Histidine Residue Specifically Affects the Binding of a Subgroup of Substituted Benzamide Drugstg.. FASEBJ8A377J. M. WetzelJ.A. Tamm, C. Forray, J. Salon, H. Nakanishi, W. Cui, G. Chiu P.J. J. Vaysse, T.A. Branchek, R.L. Weinshank, P.R. Hartugm , C. GiuchowskiMUTATION R-ZStructural and Functional Studies of the Human a1c Adrenergic Receptor: The Orientation of Transmembrane Helix 5.&&&&&  oBiological Chemistry2701398713997Jurgen WessJeongho Kim, A. Michiel van Rhee, Torsten Schoneberg and Kenneth A. JacobsonMUTATION R-ZSite-directed Mutagenesis Identifies Residues Involved in Ligand Recognition in the Human A2a Adenosine Receptor33(# EMBO1037293734Jurgen WessDavid Gdula and Mark R. BrannMUTATION R-ZSite-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist bindingJ=   > Molecular Pharmacology47660665Catherine D. StraderMargaret A. Cascieri, Lin-Lin Shiao, Sander G. Mills, Malcolm MacCoss, Christopher J. Swain Hong Yu, Elzbieta Ber, Sharon Sadowski, Mu Tsu Wu and Tung Ming FongMUTATION R-Z/GPCR MODELCharacterization of the Interaction of Diacylpiperazine Antagonists with the Human Neurokinin-1 Receptor: Identification of a Common Binding Site for Structurally Dissimilar Antagonists99%" Cellular Biochemistry50159164Guochan ZhuLan-Hsin Wu, Camilla Mauzy, Ann Marie Egloff, Taraneh MizadeganMUTATION R-ZReplacement of Lysine- 181 by Aspartic Acid in the Third Transmembrane Region of Endothelin Type B Receptor Reduces Its Affinity to Endothelin Peptides and Sarafotoxin 6c Without Affecting G Protein CouplingJJJJJ{n//$! Biological Chemistry2702172221728Ran ZhangHuiqing Cai, Naheed Fatima, Ellen Buczko, and Maria L. DufauMUTATION R-Z/CLONESFunctional Glycosylation Sites of the Rat Luteinizing Hormone Receptor Required for Ligand Bindingm11(# Biophysical66A257D. ZhangH. WeinsteinMUTATION R-ZAllosteric Regulation of the 5-T2 Receptor: Putative Role of Transmembrane Helix 29,  oMolecular Pharmacology48477485Jun YangJohn A. Williams, David I. Yule, and Craig D. LogsdonMUTATION R-ZMutation of Carboxyl-Terminal Threonine Residues in Human m3 Muscarinic Acetylcholine Receptor Modulates the Extent of Sequestration and Desensitizationob--%" Biochemical and Biophysical Research Communication18714261431Yoshiaki YamanoKenji Ohyama, Shigeyuki Chaki, Deng-Fu Guo and Tadashi InagamiMUTATION R-Z/MUTATION DISULFIDEIdentification of Amino Acid Residues of Rat Angiotensin II Receptor For Ligand Binding by Site Directed Mutagenesis%%%%%SSD@<9 A>5[Biochemistry321353713544Falk FahrenholzElzbieta Kojro, Peter Eich and Gerald GimplMUTATION A-PDirect Identification of an Extracellular Agonist Binding Site in the Renal V2 Vasopressin ReceptorfY.. Biological Chemistry2692726927274Dan DonnellyNirmala Bhogal and John B.C. FindlayMUTATION A-PThe Ligand Binding Site of the Neurokinin 2 ReceptoreX44(# Biophysical Chemistry567987Godelieve L. J. DeCaluwePetra H.M. Bovee-Geurts, Parshuram Rath, Kenneth J. Rothschild, Willem J. de GripMUTATION A-PEffect of carboxyl mutations on functional properties of bovine rhodopsinᘋ::"  FEBS307324328Theresa A. BranchekHung-Teh Kao, Nika Adham, Michael A. Olsen, Richard L. Weinshank and Paul R. HartigMUTATION A-PSite-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-HT2 receptor from a human to a rat pharmacologyz''  Molecular Pharmacology45517523Sheng Zu ZhuShou Zhen Wang, Jingru Hu and Esam E. El-FakahanyMUTATION R-Z/COUPLINGAn Arginine Residue Conserved in Most G Protein-Coupled Receptors Is Essential for the Function of the m1 Muscarinic Receptorxb11%" Molecular Pharmacology456164Jurgen WessZipora PittelMUTATION R-ZIntramolecular Interactions in Muscarinic Acetylcholine Receptors Studied with Chimeric m2/m5 ReceptorsH;..#! Biological Chemistry2692054820553Christopher K. SurrattPeter S. Johnson, Akiyoshi Moriwaki, Brian K. Seidleck, Carrie J. Blaschak, Jia Bei Wang, and George R. UhlMUTATION R-ZCharged Transmembrane Domain Amino Acids are Critical for Agonists Recognition and Intrinsic Activity>>(# Molecular Pharmacology45690695Catherine D. StraderRuey-Ruey C. Huang, Hong Yu, and Tung Ming FongMUTATION R-ZLocalization of the Ligand Binding Site of the Neurokinin-1 Receptor: Interpretation of Chimeric Mutations and Single-Residue Substitutionsuh99%" >C5@Biological Chemistry2701885318857Stuart C. SealfonWei Zhou, Vladimir Rodie, Smiljka Kitanovic, Colleen A. Flanagan, Ling Chi, Harel Weinstein, Saul Maayani, Robert P. MillarMUTATION R-ZA Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding Sites0000099(# Nature362345348Thue W. SchwartzUlrik Gether, Teit E. Johansen, R. Michael Snider, John A. Lowe III, Shigetada NakanishiMUTATION R-ZDifferent binding epitopes on the NK1 receptor for substance P and non-peptide antagonist~&&  Biological Chemistry2693095330959Thue W. SchwartzSiv A. Hjorth, Hans T. Schambye, William J. GreenleeMUTATION R-ZIdentification of Peptide Binding Residues in the Extracellular Domains of the AT1 Receptoryl88(# Biological Chemistry2692816028164Thue W. SchwartzMette M. Rosenkilde, Marie Cahir, Ulrik Gether, Siv A. HjorthMUTATION R-ZMutations along Transmembrane Segment II of the NK-1 Receptor Affect Substance P Competition with Non-peptide Antagonists but Not Substance P Bindingu88(# Nature3747477Thue W. SchwartzChristian E. Elling, Soren Moller NielsenMUTATION R-ZConversion of antagonist-binding site to metal-ion site In the tachykinin NK-1 receptorZM$$  Molecular Pharmacology42627633B.L. RothM. S. Choudhary, S CraigoMUTATION A-PIdentification of Receptor Domains that Modify Ligand Binding to 5-Hydroxytryptamine2 and 5-Hydroxytryptamine1c Serotonin ReceptorsTG..%" Biochemistry29973942Jeremy NathansMUTATION A-PDeterminants of Visual Pigment Absorbance: Role of Charged Amino Acids in the Putative Transmembrane Segments6))) Nature365603604Robert J. LefkowitzMUTATION A-PTurned on to ill effectMMMMM6)))  > @Biological Chemistry2692955729564Lee E. LimbirdBrian P. CeresaMUTATION A-PMutation of an Aspartate Residue Highly Conserved among G-protein-coupled Receptors Results in Nonreciprocal Disruption of alpha2-Adrenergic Receptor-G-protein InteractionsRE66(# Biological Chemistry2691238312386Stanley R. Krystek, Jr.Pramathesh S. Patel, Patricia M. Rose, Susan M. Fisher, Bernadette K. Kienzle, David A. Lach, Eddie C. K. Liu, Jean S. Lynch, Jiri Novotny and Maria L. WebbMUTATION A-PMutation of Peptide Binding Site in Transmembrane Region of a G Protein-coupled Receptor Accounts for Endothelin Receptor Subtype Selectivityuuuuu??(# Science250123125Roland R. FrankeBernd Konig, Thomas P. Sakmar, H. Gobind Khorana, Klaus P. HofmannMUTATION A-P/COUPLINGRhodopsin Mutants That Bind But Fail to Activate Transducini'' Molecular Pharmacology48492498Catherine D. StraderXiao-Ming Guan, Angela AmendMUTATION R-Z/COUPLINGDetermination of Structural Domains for G Protein Coupling and Ligand Binding in Beta3-Adrenergic ReceptorkU99%" Biological Chemistry26642694275H. Gobind KhoranaTomoko A. NakayamaMUTATION A-PMappingof the Amino Acids in Membrane-embedded Helices That Interact with the Retinal Chromophore in Bovine RhodopsinVI77&" Biological Chemistry2672566425667Catherine D. StraderTung Ming Fong, Ruey-Ruey C. HuangMUTATION R-ZLocalization of Agonist and Antagonist Binding Domains of the Human Neurokinin-1 Receptork^<<(# Molecular and Cellular Endocrinology107241245Stuart C. SealfonJames S. Davidson, Colleen A. Flanagan, Wei Zhou, Inga I. Becker, Ricardo Elario, Eedaad Emeran, Robert P. MillanMUTATION R-ZIdentification of N-glycosylation sites in the gonadotroin-releasing hormone receptor: role in receptor expression but not ligand bindingLLLLLöEE41.+ [>OpsEMBO632693275Catherine D. StraderRichard A. F. Dixon, Irving S. Sigal, Maria Rios Candelore, R. Bruce Register, Wendy Scattergood and Eleaine RandsMUTATION R-ZStructural features required for ligand binding to the beta-adrenergic즚((  Vision Research35S221E. SouiedGerber S., Rozet JM, Camuzat A, Dufier JL, Soubrane G, Coscas G, Munnich A and Kaplan JMUTATION A-PTwo Novel Missense Mutations of Peripherin/RDS Gene in Autosomal Dominant Retinitis Pigmentosa (ADRP), in Pedigrees from France|%% oVision Research35S131G. RestagnoA. Nardacchione, P Danese, A. Fea, FM Grignolo, AO CarbonaraMUTATION A-PAn Italian Family with ADRP and Cys-110 Tyr Mutation in the Rhodopsin Gene: Clinical Evaluation and Hetergeneity in Three Generationspc'' oBiological Chemistry2682305523058Terry ReisineHaeyoung Kong, Karen Raynor, Kazuki Yasuda, Scott T. Moe, Philip S. Portoghese, Graeme I. BellMUTATION A-PA Single Residue, Aspartic Acid 95, in the delta Opioid Receptor Specifies Selective High Affinity Agonist Binding55(# Science251558560Daniel D. OprianEugene A. Zhukovsky, Phyllis R. RobinsonMUTATION A-P/COUPLINGTransducin Activation by Rhodopsin Without a Covalent Bond to the 11-Cis-Retinal ChrompophoreeO'' Vision Research35(S)P379AH MilamLiz-Y, Cideciyan Av, Jacobson SGMUTATION A-PClinicopathologic Studies of Autosomal Dominant Retinitis Pigmentosa (Q-64-TER Rhodopsin MutationTG'' oHuman. Genet538089Jennifer P. MackeCarols M. Davenport, Samuel G. Jacobson, Jill C. Hennessey, Federico Gonzalez-Fernandez, Brain P. Conway, John Heckenlively, Rosalind Palmer, Irene H. Maumenee, Paul Sieving, Peter Gouras, William Good, and Jeremy NathansMUTATION A-PIdentification of Novel Rhodopsin Mutations Responsible for Retinitis Pigmentosa: Implications for the Structure and Function of Rhodopsin** E> Szv*CaBiological Chemistry2651576215769Gobind KhoranaTomoko A. NakayamaGPCR GENERAL O-ZOrientation of Retinal in Bovine Rhodopsin Determined by Cross-linking Using a Photocactivatable Analog of 11-cis-RetinalXH66(# FEBS Letters339269275D.T. JonesW.R. Taylor and J.M. ThorntonMUTATION A-P/GPCR MODELS H-PA mutation data matrix for transmembrane proteins_C&& Jpn J. Human Genet40271277Keiko FujikiYoshihiro Hotta, Akira Murakami, Masaru Yoshii, Mutsuko Hayakawa, Takafumi Ichikawa, Misako Takeda, Kiyoshi Akeo, Shigekuni Okisaka and Atsushi KanaiMUTATION A-PMissense Mutation of Rhodopsin Gene Codon 15 Found in Japanese Autosomal Dominant Retinitis Pigmentosa44444--! Nature3747477Christian E. EllingSoren Moller Nielsen and Thue W. SchwartzMUTATION A-PConversion of antagonist-binding site to metal-lon site in the tachykinin NK-1 receptor\P''  Biological Chemistry2681303013033Mariel BirnbaumerWalter Rosenthal, Anaid Antaramian, Stephanie GilbertMUTATION/COUPLINGNephrogenic Diabetes Insipidusn99(# Molecular Pharmacology227205214Huda AkilAlfred Mansour, Fan Meng, James H. Meador-Woodruff, Larry P. Taylor, Olivier CivelliMUTATION A-PSite-directed mutagenesis of the human dopamine D receptorɏ//&#  Molecular Pharmacology38517523Jurgen WessTom I. Bonner, Frank Dorje and Mark R. BrannMUTATION R-ZDelineation of Muscarinic Receptor Domains Conferring Selectivity of Coupling to Guanine Nucleotide-Binding Proteins and Second Messengersh\00%" Biological Chemistry2672566825671Catherine StraderTung Ming Fong, Hong YuMUTATIONS R-ZMolecular Basis for the Species Selectivity of the Neurokinin- 1 Receptor Antagonists CP-96,345 and RP67580]P99(# Regulatory Peptides464348Catherine StraderTung Ming Fong, Ruey-Ruey C. Huang, Hong YuMUTATION R-ZMapping the ligand binding site of the NK-1 Receptorh\11  b> @z~Annu. Rev. Pharmacol. Toxicol30633673E. C. HulmeN. J. M. Birdsall and N.J. BuckleyGPCR MODELS H-PMuscarinic Receptor SubtypesiY77,)&$ Biophysical Journal68A330Wayne L. HubbellZorheh T. Farahbakhsh, Kevin D. Ridge, Ke Yang, Dave Farrens, John Resek and H. Gobind KhoranaGPCR MODELS H-PExploring Rhodopsin Structure and Dynamics with Site Directed Spin Labeling鞎00  oBiochemistry3096869697Barry HonigKim A. Sharp, Anthony Nicholls, Richard FriedmanGPCR MODELS H-PExtracting Hydrophobic Free Energies from Experimental Data: Relationship to Protein Folding and Theoretical ModelshX(( Med. Chem3534483462Marcel HibertSusanne Trumpp-Kallmeyer, Jan Hoflack, Anne BruinvelsGPCR MODELS H-PModeling of G-Protein-Coupled Receptors: Application of Dopamine, Adrenaline, Serotonin, Acetylcholine, and Mammalian Opsin Receptorsl\'' Med. Chem3315941600Marcel F. HibertRemy Hoffmann, Robert C. Miller and Altert A. CarrGPCR MODELS H-PConformation-Activity Relationship Study of 5-HT3, Receptor Antagonists and a Definition of a Model for This Receptor Sitel\** TIPS1579J. HoflackS. Trumpp-Kallmeyer, and M. HibertGPCR MODELS H-PRe-evaluation of bacteriorhodopsin as a model for G protein-coupled receptorsK;  Molecular Pharmacology40815Marcel F. HibertSusanne Trumpp-Kallmeyer, Anne Bruinvels and Jan HoflackGPCR MODELS H-PThree-Dimensional Models of Neurotransmitter G-Binding Protein-Coupled Receptorszj22"  Biochemistry2949044913T. HaussS. Grzesiek, H. Otto, J. Westerhausen and M.P. HeynGPCR MODELS H-PTransmembrane Location of Retinal in Bacteriorhodopsin by Neutron DiffractionhX%% J. Mol. Biol213899929R. HendersonJ. M. Baldwin, T.A. CeskaGPCR MODELS H-PModel for the Structure of Bacteriorhodopsin Based on High-resolution Electron Cryo-microscopyQA(( $> oPb:TDBiochimica et Biophysica Acta815468476Peter KleinMinoru Kanehisa and Charles DeLisiGPCR MODELS H-PThe detection and classification of membrane-spanning proteinsjZ88-*'$ Proc. Natl. Acad. Sci.9011661171H. Gind KhoranaGPCR MODELS H-P/MUTATIONTwo light-transducing membrane proteins: Bacteriorhodopsin nd the mammalian rhodopsinO666'# Proc. Natl. Acad. Sci.8737183722Akinori KideraNobuhiro GoGPCR MODELS H-PRefinement of protein dynamic structure: Normal mode refinementP@55'# FASEB2A599A. R. KerlavageR.J. Feldman and J.C. VenterGPCR MODELS H-PThree Dimensional Modeling of Beta-Adrenergic and Muscarinic Cholinergic Receptors: Conserved Primary, Secondary and Tertiary Structures.L<   oNature369248251Martin KarplusGPCR MODELS H-PHow does a protein fold?LLLLL4$$$  Molecular Structure295185192Nam Sook KangJae Kwang Shin, Jeong Hycok Yoon, Mu Shik JhonGPCR MODELS H-PMolecular dynamics study on the electrostatic effect of protein conformationn^00#  Condensed Matter78137143Fritz JahnigOlle EdholmGPCR MODELS H-PCan the structure of proteins be calculatedqqqqqF6++ J. Mol. Biol226837850Fritz JahnigOlle EdholmGPCR MODELS H-PModeling of the Structure of Bacteriorhodopsin A Molecular Dynamics StudyC3(( Computer Aided Molecular Design24353Ad P. IJzermanHerman W. Th. van VlijmenGPCR MODELS H-PA molecular graphics study exploring a putative ligand binding site of the Beta-adrenoceptorbR99+)'& European J. of Pharmacology Molecular Pharmacology26895104Ad P. IJzermanEleonora M. van der Wenden, Philip J.M. van Galen and Kenneth A. JacobsonGPCR MODELS H-PMolecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2a receptor OOA><9 Endocrine2723Charles HutchinsGPCR MODELS H-P/CGCR MODEL A-HThree-dimensional models of the D1 and D2 dopamine receptorsD$$$ > W3D(eCABIOS10527535L. A. ParodiC.A. Granatir and G.M. MaggioraGPCR MODELS H-PA consensus procedure for predicting the location of alpha-Helical transmembrane segments in proteinsP@!!  Mol. Biol.48443453Saul B. NeedlemanChristian D. WunschGPCR MODELS H-PA General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two ProteinsM=** Computer Aided Molecular Design3211223T.J. MichellM.S. Tute and G.A. WebbGPCR MODELS H-PA molecular modelling study of the interaction of noradrenaline with the Beta2-adrenergic receptor`P99-*'& Mosberg, Henry I.GPCR MODELS H-PNIDA application88888( aMed. Chem Res3335343Henri MoereelsPaul A.J. JansenGPCR MODELS H-PMolecular Modeling of G-Protein Coupled Receptors Going Step by StepI9)) J. Mol. Biol225859871Terry P. LybrandKeith Maloney HussGPCR MODELS H-PThree-dimensional Structure for the Beta2 Adrenergic Receptor Protein Based on Computer Modeling StudiesN>,, Science22714351440David J. LipmanWilliam R. PearsonGPCR MODELS H-PRapid and Sensitive Protein Similarity SearchesyyyyyJ:(( Biochemical Pharmacology33833839Pierre M. LaduronGPCR MODELS H-PCriteria for Receptor sites in Binding StudiesvvvvvH888'$! Mol. Biol.157105132Jack KyteRussell F. DoolittleGPCR MODELS H-PA Simple Method for Displaying the Hydropathic Character of a ProteinG7## Med Chem Res3407418Terry P. LybrandMaria KontoyianniGPCR MODELS H-PComputer Modeling Studies of G Protein Coupled ReceptorsK;** Proc. Natl. Acad. Sci.8590129016H. KomiyaT.O. Yeates, D. C. Rees, J.P. Allen and G. FeherGPCR MODELS H-PStructure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: Symmetry relations and sequence comparisons between different speciesp`00'# > Zb\7/Science24514631473Johann DeisenhoferHartmut MichelGPCR MODELS A-GThe Photosynthetic Reaction Center from the Purple Bacterium Rhodopseudomonas viridisI9++ Nucleic Acids Research12387395John DevereuxPaul Haeberli and Oliver SmithiesGPCR MODELS A-GA comprehensive set of sequence analysis programs for the VAXcS22%" Proc. Natl. Acad.Sci8881118115Svein G. DahlOyvind Edvardsen and Ingebrigt SylteGPCR MODELS A-GMolecular dynamics of dopamine at the D2 ReceptorfV22%! Am J. Psychiatry151499Svein G. DahlCarol A. TammingaGPCR MODELS A-GMolecular Model: G Protein-Coupled ReceptorvvvvvK;** oCommunications388396M. CserzoJ.-M. Bernassau, I. Simon and B. MaigretGPCR MODELS A-GNew Alignment Strategy for Transmembrane Proteins\L$$ {Molecular Biology659685James L. CornetteKemp B. Cease, Hanah Margalit, John L. Spouge, Jay A. Berzofsky and Charles DeLisiGPCR MODELS A-GHydrophobicity Scales and Computational Techniques for Detecting Amphipathic Structures in Proteins// {Proteins: Structure, Function, and Genetics8386397Victor B. CockcroftDavid J. Osguthorpe, Eric A. Barnard and George G. LuntGPCR MODELS A-GModeling of Agonist Binding to the Ligand-Gated Ion Channel Superfamily of Receptors瓃LL9632 Current Opinion in Structural Biology2402412Steven A. BennerGPCR MODELS A-GPredicting de novo the folded structure of proteinsSCCC30-, Methods in Enzymology183403428Geoffrey J. BartonGPCR MODELS A-G[25] Protein Multiple Sequence Alignment and Flexible Patter MatchingG777%" EMBO1216931703Joyce M. BalwinGPCR MODELS A-GThe probable arrangement of the helices in protein-coupled receptorsxxxxx4$$$  DNA and Cell Biology11120William C. ProbstLenore A. Snyder, David I. Schuster, Jurgen Brosius and Stuart C. SealfonGPCR MODELS H-PReview Article Sequence Alignment of the G-Protein Couple Receptor Superfamily؊z11  > c!TTIPS11492499John FindlayElias EliopoulosGPCR MODELS A-GThree-dimensional modelling of G protein-linked receptorsxxxxx?/  Ann. Rev. Biophys.Biophys.Chem15321353D. M. EngelmanT. A. Steitz and A. GoldmanGPCR MODELS A-GIdentifying nonpolar transbilayer helices in amino acid sequences of membrane proteinsfV;;-*'% Biochemistry3161446151Donald M. EngelmanTheodore W. KahnGPCR MODELS A-GBacteriorhodopsin Can Be Refolded from Two Independently Stable Transmembrane Helices and the Complementary Five-Helix FragmentO?// Proc. Natl. Acad.Sci.81140144David EisenbergRobert M. Weiss and Thomas C. TerwilligerGPCR MODELS A-GThe hydrophobic moment detects periodicity in protein hydrophobicityl\33$! Proteein Science25570Dan DonnellyJohn P. Overington, Stuart V. Ruffle, Jonathan H.A. Nugent and Tom L. BlundellGPCR MODELS A-GModeling alpha-helical transmembrane domains: The calculation and use of substitution table for lipid-facing residuesv(( Biochemical Society Transactions21869873Dan DonnellyJohn B. C. Findlay, Nirmala Bhogal, Craig Hurrell and Teresa K. AttwoodGPCR MODELS A-GSignalling from the Plasma Membrane to the NucleusĒ;;/,)' Protein Engineering6629635Dan DonnellyRichard J. CogdellGPCR MODELS A-GPredicting the point at which transmembrane helices protrude from the bilayer: a model of the antena complexes from photosynthetic bacteriaO?--! FEB251109116D. DonnellyM.S. Johnson, T.L. Blundell and J. SaundersGPCR MODELS A-GAn analysis of the periodicity of conserved residues in sequence alignments of G-protein coupled receptorsYI  Current Opinion in Structural Biology4582589Dan DonnellyJohn BC FindlayGPCR MODELS A-GSeven-helix receptors: structure and modelling^N??30-, a> ?h#=Biophycical68A21G.F.X. SchertlerV.M. Unger, P.A. HargraveGPCR Models Q-ZLocalization of the Transmembrane helices in the three-dimensional structure of frog rhodopsinO@'' oBiophysical6817761786Gebhard F. X. SchertlerVinzenz M. UngerGPCR Models Q-ZLow Resolution Structure of Bovine Rhodopsin Determined by Electron Cryo-MicroscopyRC33  Proc. Natl. Acad. Sci.9284388442M. SasaiGPCR Models Q-ZConformation, energy, and folding ability of selected amino acid sequences>///'#   Biophysy21281298Mark S.P. SansomGPCR Models Q-ZThe roles of serine and threonine sidechains in ion channels: a modelling study7(((  Biophysical6812951310Mark S. P. SansomHyeon S. Son, Ramasubbu Sankararamakrishnan, Ian D. Kerr and Jason BreedGPCR Models Q-Z/GPCR MODEL G-ZSeven-Helix Bundles: Molecular Modeling via Restrained Molecular Dynamicsޔu--  Current Oppion in Biology6437451Andrej SaliGPCR Models Q-ZModelling mutations and homologous proteinslllllA222'$!   Biochemistry3094039413M. RothB. Arnoux, A. Ducruix and F. Reiss-HussonGPCR Models Q-ZStructure of the Detergent Phase and Protein-Detergent Interactions in Crystals of the Wild-Type (Strain Y) Rhodobacter sphaeroides Photochemical Reaction\M$$ Nature340659662M. RothA. Lewit-Bentley, H. Michel, J. Deisenhofer, R. Huber and D. OesterheltGPCR Models Q-ZDetergent structure in crystals of a bacterial photosynthetic reaction centresd  Med Chem Res3344356Timothy K. GallaherIan S. Haworth and Jean C. ShihGPCR MODELS A-GDetermining the ligand binding site of the 5-HT2 Receptor using molecular mechanics and molecular dynamics\L-- Proc. Natl. Acad.Sci.81155159Janet Finer-MooreRobert M. StroudGPCR MODELS A-GAmphipathic analysis and possible formation of the ion channel in an acetylcholine receptorUE55$! > o-Protein Engineering65964Gert VriendPhilippe CronetGPCR Models Q-ZModeling of transmembrane seven helix bundlesuuuuuH9** Molecular Biology23611051122P. TufferyC. Etchebest, J.-L. Popot and R. LaveryGPCR Models Q-ZPrediction of the Positioning of the Seven Transmembrane alpha-helices of BacteriorhodopsincT--# Med. Chem.3728742888Martha M. TeeterMark Froimowitz, Boguslaw Stec, and Curtis J. DuRandGPCR Models Q-ZHomology Modeling of the Dopamine D2 Receptor and Its Testing by Docking of Agonists and Tricyclic Antagonistsn_++ Biological Chemistry2651689116897Catherine D. StraderMichael R. TotaGPCR Models Q-ZCharacterization of the Binding Domain of the Beta-Adrenergic Receptor with the Fluorescent Antagonist CarazololZK<<(# FEBS LettersGPCR Models Q-Z342711Jorg SoppaGPCR Models Q-ZTwo hypotheses - one answer Sequence comparison does not support an evolutionary link between halobacterial retinal proteins including bacteriorhodopsin and eukaryotic G-protein-coupled receptorsA222(&%" Proteins: Structure, Function and Genetics8103117Jere P. SegrestHans De Loof, Jan G. Dohlman, Christie G. Brouillette and G.M. AnantharamaiahGPCR Models Q-ZAmphipathic Helix Motif: Classes and PropertiesӣGG8521 Biophysical7121135Marianne SchifferAllen B. EdmundsonGPCR Models Q-ZUse of Helical Wheels to Represent the Structures of Proteins and to Identify Segments with Helical PotentialK<** Neuroscience Abstracts1769Tracy A. SpaldingDavid Hill-Eubanks and Mark R. BrannGPCR Models Q-ZThe Structure of the Ligand Binding Domains of a Muscarinic Receptor Investigated by Random-Saturation MutagenesiseV22!! kNature362770772Gebhard F. X. SchertlerClaudio Villa and Richard HendersonGPCR Models Q-ZProjection structure of rhodopsin_P--  > +8wu%"Tom BlundellGPCR INTERACTIONSBrain "Identifier Sequence"?????$ a!Biochemical Pharmacology404954Ronald W. BehlingLynn W. JelinskiGPCR INTERACTIONSImportance of the Membrane in Ligand-Receptor InteractionsWF66%#!  Molecular BiologyGebhard E.X. SchertlerThree Dimensional Structure of Bovine Rhodopsin at 9A Resolutionnnnnn.... cPharmacology Biochemistry & Behavior4010191031Richard B. WestkaemperRichard A. GlennonGPCR Models Q-ZApproaches to Molecular Modeling Studies and Specific Application to Serotonin Ligands and Receptorsl]KK51-+ Med Chem Res3317334Richard B. WestkaemperRichard A. GlennonGPCR Models Q-ZMolecular Graphics Models of Member of the 5-HT2 Subfamily: 5-HT2a, 5HT2b, and 5-HT2c ReceptorsQB00 Med Chem Res3357369Harel WeinsteinDaqun ZhangGPCR Models Q-Z/GPCR MODEL G-ZLigand Selectivity and the Molecular Properties of the 5-HT2 Receptor: Computational Simulations Reveal a Mayor Role for Transmembrane Helix 7S4)) FEBS Letters337207212Harel WeinsteinDaqun ZhangGPCR Models Q-ZPolarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsinE6++ Biophys J Biophysical Society62110111Harel WeinsteinJuan A. BallesterosGPCR Models Q-ZThe role of Pro/Hyp-kinks in determining the transmembrane helix length and gating mechanism of a [Leu]zervamicin channel]N;;,)&$ Biophys J Biophysical Society62107109Harel WeinsteinJuan A. BallesterosGPCR Models Q-ZAnalysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains]N;;,)&$ Proc. Natl. Acad. Sci8940094012Harel WeinsteinLeonardo Pardo, Juan Antonio Ballesteros, Roman OsmanGPCR Models Q-ZOn the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors22222yj55&" > D-jU{,TIPS11280284Alan R. FershtWalter H.J. Ward and David TimmsGPCR INTERACTIONSProtein engineering and the study of structure-function relationships in receptorsRA!!  +Biochemistry3377537759Dale G. DrueckhammerKen C. Usher, S. James Remington and David P. MartinGPCR INTERACTIONSA Very Short Hydrogen Bond Provides Only Moderate Stabilization of an Enzyme-Inhibitor Complex of Citrate Synthaseve11 *Mol. Biol.217389398Andrew J. DoigDudley H. WilliamsGPCR INTERACTIONSIs the Hydrophobic Effect Stabilizing or Destabilizing in Proteins? The Contribution of Disulphide Bonds to Protein StabilityK:(( )Physical Chemistry981343713439David A. DixonKerwin D. DobbsGPCR INTERACTIONSAmide-Water and Amide-Hydrogen Bond StrengthsSB33%  (Acc. Chem.Res.24290296Gautam R. DesirajuGPCR INTERACTIONSThe C-H...O Hydrogen Bond in Crystals: What Is It?sssss@/// 'Science24910441045Antony M. DeanDaniel E. Koshland, Jr.GPCR INTERACTIONSElectrostatic and Steric Contributions to Regulation at the Active Site of Isocitrate DehydrogenaseO>'' &Nature366510511D. ColquhounM. FarrantGPCR INTERACTIONSThe Binding issueNNNNN=,""  %Science26418871890W.W. ClelandMaurice M. KreevoyGPCR INTERACTIONSLow-Barrier Hydrogen Bonds and Enzymic CatalysisxxxxxH7%% $Med. Chem3721002105David W. ChristiansonRichard S. AlexanderGPCR INTERACTIONSIdentification of Two Hydrophobic Patches in the Active-Site Cavity of Human Carbonic Anhydrase II by Solution-Phase and Solic-State Studies and Their Use in the Development of Tight-Binding InhibitorsTC// #Physical Organic Chemistry7705711Aurelie ChardinMichel Berthelot and Christian LaurenceGPCR INTERACTIONSCarbonyl Oxygen as a Hydrogen-Bond Super-Base: The Amidateso^77(%"! > * 55Mol. Biol.214613617Alan R. FershtAmnon HorovitzGPCR INTERACTIONSStrategy for Analysing the Co-operativity of Intramolecular Interactions in Peptides and ProteinsG6(( 4Phil. Trans. R. Soc. Lond. A.317305320A. R. FershtR.J. Leratherbarrow and T.N.C. WellsGPCR INTERACTIONSStructure and activity of the tyrosyl-tRNA synthetase: the hydrogen bond in catalysis and specificityn]99-*'$ 3Biochemistry2993439352Alan R. FershtLuis Serrano, Amnon Horovitz, Boaz Avron, Mark BycroftGPCR INTERACTIONSEstimating the Contribution of Engineered Surface Electrostatic Interactions to Protein Stability by Using Double-Mutant Cyclesra++ 2Biochemistry2451065109Alan R. FershtDenise M. Lowe and Anthony J. WilkinsonGPCR INTERACTIONSProbing Histidine-Substrate Interactions in Tyrosyl-tRNA Synthetase Using Asparagine and Glutamine ReplacementscR++ 1Biochemistry2660386043Alan R. FershtDenise M. Lowe, Greg WinterGPCR INTERACTIONSStructure-Activity Relationships in Engineered Proteins: Characterization of Disruptive Deletions in the alpha-Ammonium Group Binding Site of Tyrosyl-tRNA SynthetaseWF++ 0J. Mol. Biol.218465475Alan R. FershtLuis Serrano, Mark BycroftGPCR INTERACTIONS/INTERACTIONS/THERMOAromatic-Aromatic Interactions and Protein Stability Investigation by Double-mutant CyclesjE++ /TIBS12301304Alan R. FershtGPCR INTERACTIONSThe hydrogen bond in molecular recognition\\\\\2!!!  .Nature314235238Alan R. FershtJian-Ping Shi, Jack Knill-Jones, Denise M. Lowe, Anthony J. Wilkinson, David M. Blow, Peter Brick, Paul Carter, Mary M. Y. Waye and Greg WinterGPCR INTERACTIONSHydrogen bonding and biological specificity analysed by protein engineeringij$$  -Biochemistry2715771580Alan R. FershtGPCR INTERACTIONSRelationships between Apparent Binding Energies Measured in Site-Directed Mutagenesis Experiments and Energetics of Binding and Catalysis<+++ ]> W EnL{?Proc.Natl. Acad.Sci7840464050William P. JencksGPCR INTERACTIONSOn the attribution and additivity of binding energies{{{{{F555$  >Photochemistry and Photobiology856975Andrzej JankowskiWieslaw Wiczk, Tadeusz JaniakGPCR INTERACTIONSMechanism of proton transfer in proteins II. Relationship between local properties of solvent and rate of excited state proton transfer for 2-naphthol derivatives bound to selected sites of proteins33333kZ==,*(& =Am. Chem. Soc.11255255534Christopher A. HunterJeremy K.M. SandersGPCR INTERACTIONSThe Nature of Pi-Pi InteractionszzzzzYH55  <Mol. Bio.233524535Kazuaki HarataMichiro Muraki and Yoshifumi JigamiGPCR INTERACTIONSRole of Arg 115 in the Catalytic Action of Human Lysozyme X-ray Structure of His 115 and Glu115 Mutants[J'' ;Am. Chem Soc.11549414942Mark M. GreenChetan Khatri, and Norman C. PetersonGPCR INTERACTIONSA Macromolecular Conformational Change Driven by a Minute Chiral Solvation EnergybQ,, :Laser Chem13187205Albert J. GotchNathan Pribble, Frederick A. Ensminger, and Timothy S. ZwierGPCR INTERACTIONSThe Spectroscopy and Photophysics of Hydrogen-Bonded complexes: benzen-CHCI3ud(( 9American Chemical Society11439863988Greg S. GormanJ. Paul Speir, Cheryl A. Turner and I. Jonathan AmsterGPCR INTERACTIONSProton Affinities of the 20 Common alpha-Amino Acidso99+'#  8Am. Chem. Soc.11347144715Paul R. GibbsAnna Radzicka and Richard WolfendenGPCR INTERACTIONSThe Anomalous Hydrophilic Character of ProlineaP--  7Science26419271930Perry A. FreySean A. Whitt and John B. TobinGPCR INTERACTIONSA Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine ProteasesVE&& 6Mol. Biol.235709717Maria M. FloccoSherry L. MowbrayGPCR INTERACTIONSPlanar Stacking Interactions of Arginine and Aromatic Side-Chains in ProteinsK:)) x> #WxrIMol. Biol.239315331John B.O. MitchellC. Lilian Nandi, Ian K. McDonald, Janet M. ThorntonGPCR INTERACTIONSAmino/Aromatic Interactions in Proteins: Is the Evidence Stacked Against Hydrogen Bonding?p_,, HMol. Biol.201751754Michael LevittMax F. PerutzGPCR INTERACTIONSAromatic Rings Act as Hydrogen Bond AcceptorssssssF5(( GPharmac. Ther.60149167J. Andrew McCammonBogdan LesyngGPCR INTERACTIONSMolecular Modeling Methods. Basic Techniques and Challenging ProblemsMJPjAm. Chem. Soc.10679467958H. A. ScheragaG.T. Montelione, E. Arnold, Y.C. Meinwald, E.R. Stimson, J.B. Denton, S.-G. Huang, and J. ClardyGPCR INTERACTIONSChain-Folding Initiation Structures in Ribonuclease A; Conformational Analysis of trans-Ac-Asn-Pro-Tyr-NHMe and trans-Ac- Tyr-Pro-Asn-NHMe in Water and in the Solid StateIIIII..  ONature362735737David A. RodhamSakae Suzuki, Richard D. Suenram, Frank J. Lovas, Siddharth Dasgupta, William A. Goddar III and Geoffrey A. BlakeGPCR INTERACTIONSHydrogen bonding in the benzene-ammonia dimerԧ%%  NBiochemistry2152525262Harold A. ScheragaEvelyn R. Stimson, Gaetano T. Montelione, Yvonne C. Meinwald, Rainer K.E. RudolphGPCR INTERACTIONSEquilibrium Ratios of cis- and trans-Proline Conformers in Fragments of Ribonuclease A from Nuclear Magnetic Resonance Spectra of Adjacent Tyrosine Ring Resonances44444// MBiochemistry301005810064Belinda PastranaAlan J. Mautone and Richard MendelshnGPCR INTERACTIONSFourier Transform Infrared Studies of Secondary Structure and Orientation Pulmonary Surfactant SP-C and Its Effect on the Dynamic Surface Properties PhospholipidseT// LAm. Chem. Soc.11644974498S. PaliwalS. Geib and C.S. WilcoxGPCR INTERACTIONSMolecular Torsion Balance for Weak Molecular Recognition Forces. Effects of "Tilted-T" Edge-to-Face Aromatic Interactions on Conformational Selection and Solid-State StructureRA**  KAm. Chem. Soc.10610181025Peter Murray-RustJenny P. GluskerGPCR INTERACTIONSDirectional Hydrogen Bonding to sp2- and sp3- Hybridized Oxygen Atoms and Its Relevance to Ligand-Macromolecule InteractionsRA11  JPharmacology and Experimental Therapeutiecs273367372Hiroto MiwaIra Gantz, Yoshitaka Konda, Yoshimasa Shimoto and Tadataka YamadaGPCR INTERACTIONSStructural Detrminants of the Melanocortin Peptides Required for Activation of Melanocortin-3 and Melanocortin-4 ReceptorsFF;852 >WPhysical Society of Japan6217821793Kunitsugu SodaGPCR INTERACTIONSSolvent Excusion Effect Predicted by the Scaled Particle Theory as an Important Factor of the Hydrophobic EffectI888*&"  VNature319407409Mark SchumacherShelley Camp, Yves Maulet, Michael Newton, Kathleen MacPhee-Quigley, Susan S. Taylor, Theodore Friedmann and Palmer TaylorGPCR INTERACTIONSPrimary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence %%  UProc.Natl.Acad.Sci.7948434847Kenneth A. ThomasGraham M. Smith, Theresa B. Thomas, and Richard J. FeldmannGPCR INTERACTIONSElectronic distributions within protein phenylalanine aromatic rings are reflected by the three-dimensional oxygen atom environments.p55$  TBiochemical and Biophysical Research Communication183577583Mariko TaruiHarumi Furumura, Yayoi Kafuku, Toshimasa Ishida and Masatoshi InoueGPCR INTERACTIONSMutual Assistance of Hydrogen-Bond Pairing and Aromatic Stacking Interactions for Molecular Recognition: Spectroscopic Study on the Interaction of Guanine Base with Cytosine and Tryptophan MoleculesiiiiiNNB?<9 SAcc. Chem. Res.17320326Robin TaylorOlga KennardGPCR INTERACTIONSHydrogen-Bond Geometry in Organic CrystalsqqqqqG6** RBiopolymers (Peptide Science)37281292Giuliano SiligardiAlex F. DrakeGPCR INTERACTIONSThe Importance ofExtended Conformtions and, in Particular, the p11 Conformation for the Molecular Recognition of Peptides\K>>,)&$ QAm. Chem. Soc.10679597969H. A. ScheragaM. Oka, G.T. MontelioneGPCR INTERACTIONSChain-Folding Initiation Structures in Ribonuclease A: Conformational Free Energy Calculations on Ac-Asn-Pro-Tyr-NHMe, Ac-Tyr-Pro-Asn-NHMe, and Related PeptidesVE..  R> kl_Biophysical Journal6910771082David Garcia-QuintanaAndres Francesh, Pere Garriga, Angel R. de Lera, Esteve Padros and Joan ManyosaACTIVATIONFourier Transform Infrared Spectroscopy Indicates a Major Conformational Rearrangement in the Activation of Rhodopsin99$  ^Science26514051412David E. ColemanAlbert M. Berghuis, Ethan Lee, Maurine E. Linder, Alfred G. Gilman and Stephen R. SprangCOUPLINGStructures of Active Conformations of G and the Mechanism of GTP HydrolysisՉ)) ]Nature365403406David E. ClaphamEva J. NeerCOUPLINGNew roles for G-protein Beta Gamma-dimers in transmembrane signalling~~~~~91&&  \Biological Chemistry2702282022826Krishan K. AroraAtsushi Sakai and Kevin J. CattCOUPLINGEffects of Second Intracellular Loop Mutations on Signal Transduction and Internalization of the Gonadotropin-releasing Hormone Receptor_W88(# [Medicinal Chemistry36934938Harel WeinsteinDaqun ZhangGPCR INTERACTIONS/GPCR MODEL G-ZSignal Transduction by a 5-HT2 Receptor: A Mechanistic Hypothesis from Molecular Dynamics Simulations of the Three-Dimensional Model of the Receptor Complexed to Ligands]<11" ZGregory A. WeilandKenneth P. Minneman & Perry B. MolinoffGPCR INTERACTIONSFundamental difference between the molecular interactions of agonists and anatagonists with the Beta-adrenergic receptorQ@ aYMol. Biol.226923929Polly S. VermerschJohn J. G. Tesmer and Florante A. QuiochoGPCR INTERACTIONS/H BONDINGProtein-Ligand Energetics Assessed Using Deoxy and Fluorodeoxy Sugars in Equilibrium Binding and High Resolution Crystallographic StudiespU,, XScience253872879Joel L. SussmanMichal Harel, Felix Frolow, Christian Oefner, Adrian Goldman, Lilly Toker, Israel SilmanGPCR INTERACTIONSAtomic Structure of Acetylcholinesterase from Torpedo californica: A Prototypic Acetylcholine-Binding Protein~&& > |(jmhBiological Chemistry2601415014157Steen E. PedersenElliott M. RossCOUPLINGFunctional Activation of Beta-Adrenergic Receptors by Thiols in the Presence or Absence of AgonistsPH99(# gBiological Chemistry26783428346Takashi OkamotoIkuo NishimotoCOUPLINGDetection of G Protein-activator Regions in M4 Subtype Muscarinic, Cholinergic, and alpha2- Adrenergic Receptors Based upon Characteristics in Primary StructureKC55&" fArchives of Pharmacology350329338Stefan OffermannsGunter SchultzCOUPLINGComplex information processing by the transmembrane signaling system involving G proteinsOG99(%" eNature365166170Tsunehlsa NambaYuklhiko Sugimoto, Manabu Negishl, Atsushi Irle, Fumitaka Ushiikubl, Aklra Kaklzuka, Seiji Ito, Atsushi Ichlkawa and Shuh NurumiyaCOUPLINGAlternative splicing of c-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity%%  dMolecular Pharmacology14370375Robert J. LefkowitzLinda Joy PikeGPCR/COUPLINGAgonist-Specific Alterations in Receptor Binding Affinity Associated with Solubilization of Turkey Erythrocyte Membrane Beta Adrenergic ReceptorsSF88%" cNature372276279David G. LambrightJohn Sondek, Joseph P. Noel, Heidl E. Hamm and Paul B. SiglerCOUPLINGGTPae mechanism of Gproteins from the 1.7-A crystal structure of transducin Alpha GDP AIFme((  bScience26214161419Wayne L. HubbellZohreh Toossi Farahbakhsh, Kalman HidegCOUPLINGPhotoactivated Conformational Changes in Rhodopsin: A Time-Resolved Spin Label StudyXP)) aNature372220221Roger S. GoodyCOUPLINGHow G proteins turn offCCCCC,$$$  `Ann. Rev. Biochem56615649Alfred G. GilmanGPCR/COUPLINGG Proteins: Transducers of Receptor-Generated Signalssssss=000  >LfspAm.Chem.Soc.1161053310539Mary C. ChervenakEric J. TooneGPCR CALCULATIONSA Direct Measure of the Contribution of Solvent Reorganization to the Enthalpy of Ligand BindingO>11  oof Virology6941374141L. WillemsJ.S. Gatot, M. Mammerickx, D. Portetelle, A. Burny, P. Kerkhofs and R. KettmannCOUPLINGThe YXXL Signalling Motifs of the Bovine Leukemia Virus Transmembrane Protein Are Required for In Vivo Infection and Maintenance of High Viral Loads~v'' nProtein Science32229G. WengC.X. Chen, V. Balogh-Nair, R. Callender and D. ManorCOUPLINGHydrogen bond interactions of G proteins with the guanine ring moiety of guanine nucleotides^V"" mMolecular Pharmacology45524531Wang-Ni TianEmir Duzic, Stephen M. Lanier and Richard C. DethCOUPLINGDeterminats of alpha2-Adrenergic Receptor Activation of G Proteins: Evidence for a Precoupled Receptor/B Protein Statejb11%" lBiological Chemistry26973877389Hiro TakeiYahaloma Gat, Zvi Rothman, Aaron Lewis, and Mordechail ShevesCOUPLINGActive Site Lysine Backbone Undergoes Conformational Changes in the Bacteriorhodopsin Photocycleum00&" kBiological Chemistry2672142121424Muppalla SukumarTsutomu HigashijimaCOUPLINGG Protein-bound Conformation of Mastoparan-X, a Receptor-mimetic PeptideSK88(# jPharmacology and Experimental Therapeutics27512741279Tracy A. SpaldingEthan S. Burstein, Hans Brauner-Osborne, David Hill-Eubanks and Mark R. BrannCOUPLINGPharmacology of a Constitutively Active Muscarinic Receptor Generated by Randon MutagenesisMM<841 iBiological Chemistry2621665516662Ronald C. RubensteinStephen K.F. Wong, and Elliott M. RossCOUPLINGThe Hydrophobic Tryptic Core of the Beta-Adrenergic Receptor Retains G. Regulatory Activity in Response to Agonists and Thiolsjb<<(# >G|_xNeuron9719725Daniel OprianPhyllis R. Robinson, George B. Cohen, Eugene A. ZhukovskyCONSTACTICConstitutively Active Mutants of RhodopsindZ!!  wMolecular Pharmacology45481489Brenda S. WhaleyNanyong Yuan, Lutz Birnbaumer, Richard B. Clark, and Roger BarberGPCR CALCULATIONSDifferential Expression of the Beta-Adrenergic Receptor Modifies Agonist Stimulation of Adenylyl Cyclase: A Quantitative Evaluation v55%" vTIPS16151155Stephane SwillensMagali Waelbroeck and Philippe ChampeilGPCR CALCULATIONSDoes radiolabelled ligand bind to a homogeneous population of non-interacting receptor sites?\K$$  uMolecualr Pharmacology4711971203Stephane SwillensGPCR CALCULATIONSInterpretation of Binding Curves Obtained with High Receptor Concentrations: Practical Aid for Computer AnalysisI888'# tMolecular Pharmacology40276288Douglas StickleRoger BarberGPCR CALCULATIONSComparisons of the Combined Contributions of Agonist Binding Frequency and Intrinsic Efficiency to Receptor-Mediated Activation of Adenylate CyclaseQ@44%" sCABIOS105360Burkhard RostChris Sander and Reinhard SchneiderGPCR CALCULATIONSPHD-an automatic mail server for protein secondary structure predictionTC   rBiophysical682539Mafalda NinaBenoit Roux and Jeremy C. SmithGPCR CALCULATIONSFunctional Interactions in Bacteriorhodopsin: A Theoretical Analysis of Retinal Hydrogen Bonding with WaterTC$$ qPharmacology and Experimental Therapeutics237154164Margarita L. ContrerasBarry B. Wolfe and Perry B. MolinoffGPCR CALCULATIONS/THERMODYNAMICSThermodynamic Properties of Agonist Interactions with the Beta Adrenergic Receptor-Coupled Adenylate Cyclase System. I. High- and Low-Affinity States of Agonist Binding to Membrane-Bound Beta Adrenergic ReceptorsiiiiitPP:741 .>4pC8BFFEBS Letters347279283Yan ChenYi Fan, Jian Liu, Anton Mestek, Mingting Tian, Christine A. Kozak, Lei YuCLONESMolecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene familysm$$ ~Neuron1111871195Chia-Ping ChangRichard V. Pearse II, Shawn O'Connell and Michael G. RosenfeldCLONESIdentiofication of a Seven Transmembrane Helix Receptor for Corticotropin-Releasing Factor and Sauvagine in Mammalian Brainjd&&  }Biochemical & Biophysical Research Communications20513111317Rebecca J. ChanAndrew W. McBride, and David W. CrabbCLONESSeven Transmembrane Domain Receptor Subtypes Identified in NG108-15 Cells by Reverse Transcription-Polymerase Chain Reaction}wRRC?;8 |Nature366575580Edward M. BrownGerardo Gamba, Daniela Riccardl, Michael Lombardl, Robert Butters, Olga Kifor, Adam Sun, Matthias A. Hedlger, Jonathan Lytton and Steven C. HebertCLONESCloning and characterization of an extracellular CA2+-sensing receptor from bovine parathyroid%%  {FEBS Letters351375379Tom I. BonnerZ.H. Song, W. Scott Young III, Michael J. BrownsteinCLONESMolecular cloning of a novel candidate G protein-coupled receptor from rat brainc])) zBritish J. of Pharmacology115622628Douglas W. BonhausChinh Bach, Andrea DeSouza, F.H. Rick Salazar, Barbara D. Matsuoka, Patricia Zuppan, Hardy W. Chan and Richard M. EglenCLONESThe pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptorsFFFFF<<*'$! yHuman Molecular Genetics4183188Shinji DosugiCornelis Van Dop, Mitchell E. Geffner, Wolfgang Rabl, Jean-Claude Carel, Jean-Louis Chaussain, Toru Mori, John J. Morendino Jr. and Andrew ShenkerCONSTACTICCharacterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious pubertybbbbb33&#  ^>-TFQx6vProc.Natl. Acad.Sci844650Robert J. LefkowitzBrian K. Kobilka, Richard A. F. Dixon, Thomas Frielle, Henrik G. Dohlman, Mark A. Bolanowski, Irving S. Sigal, Teresa L. Yang-Feng, Uta Francke, Marc G. 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ReganCLONESCloning of human prostanoid receptors\V$$  FEBS Letters364339341Nobuhiro NishigakiManabu Negishi, Akiko Honda, Yukihiko Sugimot, Tsunehisa Namba, Shuh Narumiya, Atsushi IchikawaCLONESIdentification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells as EP4 subtype.. Molecular Pharmacology48869879Masato KotaniIssei Tanaka, Yoshihiro Ogawa, Takeshi Usui, Kiyoshi Mori, Atsushi Ichikawa, Shuh Narumiya, Teruya Yoshimi and Kazuwa NakaoCLONESMolecular Cloning and Expression of Multiple Isoforms of Human Prostaglandin E Receptor EP3 Subtype Generated by Alternative Messenger RNA Splicing: Multiple Second Messenger Systems and Tissue-Specific Distributions22%" > -Communication2266122664Patricia M. RosePrabhavathi Fernandes, Jean S. Lynch, Scott T. Frazier, Susan M. Fisher, Krishna Kodukula, Bernadette Kienzle and Ramakrishna SeethalaCLONESCloning and Functional Expression of a cDNA Encoding a Human Type 2 Neuropeptide Y Receptor.. {Proc.Natl. Acad.Sci.9287348738Steven M. 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SeeburgCLONESLutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family$$  Science245525528Hugues LoosfeltMicheline Misrahi, Michel Atger, Roland Salesse, Mai Tu Vu Hai-Luu Thi, Andre Jolivet, Anne Guiochon-Mantel, Sokhavuth Sar, Bahija Jallai, Jean Garnier, Edwin MilgromCLONESCloning and Sequencing of Porcine LH-hCG Receptor cDNA: Variants Lacking Transmembrane Domain00000&& > B9Biochemical & Biophysical Research Communications189289295Sham S. KakarLois C. Musgrove, Daniel C. Devor, Jeffrey C. Sellers and Jimmy D. NeillCLONESCloning, Sequencing, and Expression of Human Gonadotropin Releasing Hormone (GnRH) ReceptorNNA>;8 Domestic Animal Endocrinology10335342S.S. KakarC. H. Rahe and J.D. NeillCLONESMolecular Cloning, Sequencing, and Characterizing the Bovine Receptor For Gonadotropin Releasing Hormone (GNRH)UO66,)&$ Biochemical & Biophysical Research Communications17813861392Ira GantzGerd Munzert, Takao Tashiro, Matthias Schaffer, Lidong Wang, John Del Valle and Tadataka YamadaCLONESMolecular Cloning of the Human Histamine H2 Receptor屫LLC?;8 Biochemical & Biophysical Research Communications18916451652Ursula B. KaiserDayao Zhao, Guemalli R. Cardona, and William W. ChinCLONESIsolation and Characterization of cDNAs Encoding the Rat Pituitary Gonadotropin-Releasing Hormone ReceptorSSC?;8 Melecular and Cellular Endocrinology90R5R9K.A. EidneR.E. Sellar, G. Couper, L. Anderson and P.L. TaylorCLONESMolecular cloning and characterization of the rat pituitary gonadotropin-releasing hormone (GnRH) receptortn;;1/-+ Molecular Pharmacology44812Yan ChenAnton Mestek, Jian Liu, Joyce A. Hurley, and Lei YuCLONESMolecular Cloning and Functional Expression of a mu-Opioid Receptor from Rat Brainc]**"  Molecular & Cellular Endocrinology94R23R27J. BrooksP.L. Taylor, P.T.K. Saunders, K.A. Eidne, W.J. Struthers and A.S. McNeillyCLONESCloning and sequencing of the sheep potuitary gonadotropin-releasing hormone receptor and changes in expression of its mRNA during the estrous cycle::1.+) Molecular Pharmacology4810541062Delia BelelliJoanna M. Balcarek, Anthony G. Hope, John A. Peters, Jeremy J. Lambert, and Thomas P. BlackburnCLONESCloning and Functional Expression of a Human 5-Hydroxytryptamine Type 3As Receptor Subunit44'# >>V"9VBiochemical & Biophysical Research Communications196745751Stuart C. SealfonNicola Illing, Greta F. M. Jacobs, Inga I. Becker, Colleen A. Flanagan, James S. Davidson, Audrey Eales, Wei Zhou, and Robert P. MillarCLONESComparative Sequence Analysis and Functional Characterization of the Cloned Sheep Gonadotropin-Releasing Hormone Receptor Reveal Differences in Primary Structure and Ligand Specificity Among Mammalian ReceptorsRRA>;8 Molecular Endocrinology611631169Stuart C. SealfonManami Tsutsumi, Wei Zhou, Robert P. Millar, Pamela L. Mellon, James L. Roberts, Colleen A. Flanagan, Kewen Dong, Boaz GilloCLONESCloning and Functional Expression of a Mouse Gonadotropin-Releasing Hormone Receptor88'# Molecular and Cellular Endocrinology91R1R6S.C. SealfonL. Chi, W. Zhou, A. Prikhozhan, C. Flanagan, J.S. Davidson, M. Golembo, N. Illing, R.P. MillarCLONESCloning and characterization of the human GnRH receptorء==1/-+ Biochemical & Biophysical Research Communications19710621069Hans-Peter NothackerCornelis J.P. GrimmelikhuijzenCLONESMolecular Cloning of a Novel, Putative G Protein-Coupled Receptor from Sea Anemones Structurally related to members of the FSH, TSH, LH/CG Receptor Family From Mammals"""""{uWWC?;8 Trends in Biotechnology124749Ann MillsMichael J. DugganCLONESOrphan seven transmembrane domain receptors: reversing pharmacologyD>--$"  Genomics23609618Adriano MarcheseJohn M. Docherty, Tuan Nguyen, Michael Heiber, Regina Cheng, Henry H. Q. Heng, Lap-Chee Tsui, Xiaomei Shi, Susan R. George, and Brian F.O'DowdCLONESCloning of Human Genes Encoding Novel G Protein-Coupled Receptors'' Biological Chemistry269232237Marcel LoetscherThomas Geiser, Terry O'Reilly, Roland Zwahlen, Marco Baggiolini, and Bernhard MoserCLONESCloning of a Human Seven-transmembrane Domain Receptor, LESTR, That Is Highly Expressed in Leukocytes44$! >  OHBiochemistry32421425Pingchiang C. LyuDavid E. WemmerGPCR MODELS H-PCapping Interactions in Isolated alpha Helices: Position-Dependent Substitution Effects and Structure of a Serine-Capped Peptide HelixJ;,, TIBS159395Fritz JahnigGPCR MODELS H-PStructure predictions of membrane proteins are not that badggggg,  Computer-Aided Molecular Design7649658G. VriendL. Oliveira, A.C.M. PaivaGPCR Model Q-ZA common motif in G-protein-coupled seven transmembrane helix receptors]O66-*'& Biophysical6618231630A.G. SzaboK.J. Willis, W. Neugebauer, M. SikorskaGPCR Model Q-ZProbin alpha-Helical Secondary Structure at a Specific Site in Model Peptides via Restriction of Tryptophan Side-Chain Rotamer Conformation[M&& Celia Foundation Symposium17696111Paul C. SternweisAlan V. SmrckaGPCR Model Q-ZG proteins in signal transduction: the regulation of phospholipase CVH::)&$! Int. J. Peptide Protein Res.39356363R. SankararamakrishnanSaraswathi VishveshwaraGPCR Model Q-ZGeometry of proline-containing alpha-helices in proteinsfXAA+(%# Biopolymer30287298R. SanararamakrishnanSaraswathi VishveshwaraGPCR Model Q-ZConformational Studies on Peptides with Proline in the Right-Handed alpha-Helical RegionSE.. Israel Journal of Chemistry34245252Christine S. RingFred E. CohenGPCR Model Q-ZConformational Sampling of Loop Structures Using Genetic AlgorithmsVH;;*'$" 3333332531William WisdenEric M. Parker, Cathy D. Mahle, Darcy A. Grisel, Henry P. Nowak, Frank D. Yocca, Christian C. Felder, Peter H. Seeburg and Mark VoightCLONESCloning and characterization of the rat 5-HT5b receptor. Evidence that the 5-Ht5b receptor couples to a G protein in mammalian cell membranes99999  _> }}Protein Science215021510V. ColluraJunichi Higo and J. GarnierGPCR MODELS A-GModeling of protein loops by simulated annealingSD)) Nature364355358Adam P. BrunetEnoch S. Huang, Mary Elixabeth Huffnot, Jonathan E. Loeb, Robert J. Weltman and Michael H. HechtGPCR MODELS A-GThe role of turns in the structure of an alpha-helical proteinѓ$$  EMBO1216931703Joyce M. BaldwinGPCR MODELS A-GThe probable arrangement of the helices in G protein-couple receptorsyyyyy4%%%  Current Opinion in Cell Biology6180190Joyce M. BaldwinGPCR MODELS A-GStructure and function of receptors coupled to G proteinsL===-*'& Peptides15731755Jacqueline N. CrawleyRebecca L. CorwinGPCR A-NBiological Actions of CholecystokininjjjjjE=,, Vision Res.2618811895Meredithe L. AppleburyPaul HargraveGPCR A-NMolecular Biology of the Visual PigmentsoooooG?22 Molecular Biology237182192Bengt PerssonPatrick ArgosGPCR MODELS H-PPrediction of Transmembrane Segments in Proteins Utilizing Multiple Sequence AlignmentsJ;..! Biological Chemistry2692338323386Jeffrey H. PerlmanLisa Laakkonen, Roman Osman and Marvin C. GershengornGPCR MODELS H-PA Model of the Thyrotropin-releasing Hormone (TRH) Receptor Binding Pocket~o::(# Biochemistry3213551135559Luis MoroderRoberta Romano, Wolfgang Guba, Dale F. Mierke, Horst Kessler, Christine Delporte, Jacques Winand, and Jean ChristopherGPCR MODELS H-PNew Evidence for a Membrane-Bound Pathway in Hormone Receptor Binding,,  Biochemistry3361296136A. E. McDermottF. Creuzet, R. Gebhard, K. van der Hoef, M.H. Levitt, J. Herzfeld, J. Lugtenburg and R.G. GriffinGPCR MODELS H-PDetrmination of Internuclear Distances and the Orientation of Functional Groups by Solid -State NMR: Rotation Resonance Study of the Conformation of Retinal in BacteriorhodopsinMMMMM,, B> 8x^J. Phys. Chem9514371444A Ben-NaimGPCR INTERACTIONS/INTERACTION THERMOThe Role of Hydrogen Bonds in Protein Folding and Protein AssociationL((( Synapse216064Richard B. RothmanHeng Xu, Jia Bei Wang, John S. Partilla, Hiroshi Kayakiri, Kenner C. Rice, and George R. UhlGPCR General O-ZLigand Selectivity of Cloned Human and Rat Opioid Mu ReceptorsВ&& Int.J. Peptide Protein Res42420431M. Michael GromihaP.K. PonnuswamyGPCR MODELS A-GPrediction of transmembrane Beta-strands from hydrophobic characteristics of proteinsYJ;;)&#! Mol. Biol1757581T.M. GrayB. W. MatthewsGPCR MODELS A-GIntrahelical Hydrogen Bonding of Serine, Threonine and Cysteine Residues Within alpha-Helices and its Relevance to Membrane-bound Proteins=.  Protein Engineering7195203J.B.C. FindlayT.K. AttwoodGPCR MODELS A-GFingerprinting G-protein-coupled receptorstttttJ;//! American Chemical Society11635933594Frank GuarnieriMatthew T. Burger, Alan Armstron, D. Quentin McDonald, and W. Clark StillGPCR MODELS A-G/GPCR CALCULATIONSFree Energy Calculation in Molecular Design: Predictions by Theory and Reality by Experiment with Enantioselective Podand Ionophores)))))::+'#  Global Optimization4209227David M. FergusonAmanda Marsh, Thomas MetzgerGPCR MODELS A-GConformational Searches for the Global Minimum of Protein Models]N22! Molecular Structure (Theochem)314265276P.G. De BenedettiF. Fanelli, M.C. Menziani, M. Cocchi, A. LeonardiGPCR MODELS A-GThe heuristic-direct approach to theoretical quantitative structure-activity relationship analysis of alpha1-adrenoceptor ligandsp??.+(% Quanton Chemistry: Quanton Biology Symposium19197215R.H. DaviesD. Timms, A.J. Wilkinson, D.R. Kelly K.J. BroadleyGPCR MODELS A-GInteraction Tyr377 in a Ligand-Activation Model of Signal Transmission through Beta1-Adrenoceptor alpha-HelicesxFF;853 >zd~Am. Chem.Soc11599079919Patrick C. KearneyLaura S. Mizoue, Robert A. Kumpf, Jonathan E. Forman, Alison McCurdy and Dennis A. DoughertyGPCR INTERACTIONSMolecular Recognition in Aqueous Media. New Binding Studies Provide Further Insights into the Cation-pi Interaction and Related Phenomena'''''00 Chemical Physics Letters217319324Pavel JungwirthRudolf ZahradnikGPCR INTERACTIONSThe entropy driven hydrophobic effect as a function of solute-solvent interactions. A molecular dynamics studyXG77(%" Molecular Microbiology11417Emma S. HennesseyJenny K. Broome-SmithGPCR INTERACTIONSTwo related bacterial membrane proteins, ExbD and ToIR, have opposite transmembrane charge dipolarityYH33"" oProtein Science4936944Philip K. HammenJ. Martin Scholtz, J. William Anderson, E. Bruce Waygood, and Rachel E. KlevitGPCR INTERACTIONSInvestigation of a side-chain-side-chain hydrogen bond by mutagenesis, thermodynamics, and NMR spectroscopy{-- Supramolecular Chemistry5281287Michael G.B. DrewVitor Felix, Vickie McKee, Grace Morgan and Jane NelsonGPCR INTERACTIONSThe importance of interactions between methyl groups and aromatic rings in homo and hetero-cyclophane structures. A molecular mechanics and x-ray crystallographic investigation00000n77&#  Biochemistry341363513641Ursula M. D'SouzaPhilip G. StrangeGPCR INTERACTIONSpH Dependence of Ligand Binding to D2 Dopamine ReceptorsRA00 Proteins:Structure, Function & Genetics10130139Martha D. BruchMadan M. Dhingra and Lila M. GieraschGPCR INTERACTIONSSide Chain-Backbone Hydrogen Bonding Contributs to Helix Stability in Peptides Derived From an alpha-Helical Region of Carboxypeptidase A{jEE630. C&E News3334Stu BormanGPCR INTERACTIONS/H BONDINGMolecular Recognition Found In Simple Alcohol-Amine Complexesuuuuu8 {>6HQLife Sciences5418311844G.A. CabralK. Fischer-StengerCB IMMUNEInhibition of Macrophage Inducible Protein Expression by Delta-9-TetrahydrocannabinolD;)) Pharmacology and Experimental Therapeutics27312161223A, CabralKathleen L. McCoy and David GaineyCB IMMUNEDelta9-Tetrahydrocannabinol Modulates Antigen Processing by MacrophagespgEE<841 Pharmacology and Experimental Therapeutics26715581565K. Fischer-StengerD.A. Dove Pettit and G.A. CabralCB IMMUNEDelta9-Tetrahydrocannabinol Inhibition of Tumor Necrosis Factor-alpha:Suppression of Post-translaltional EventswnNN<841 Biological Chemistry2702468224685Jeffrey H. PerlmanWei Wang, Daniel R. Nussenzveig, and Marvin C. GershegornDISULFIDEThe Agonist Binding Site on the Bovine Bradykinin B2 Receptor Is Adjacent to a Sulfhydryl and Is Differentiated from the Antagonist Binding Site by Chemical Cross-linking&&&&&|s::(# Phys. Chem8728692881Harold A. ScheragaKuo-Chen Chou, George NemethyGPCR INTERACTIONSEnergetic Approach to the Packing of alpha-Helices. 1. Equivalent Helices[J-- Am. Chem.Soc.10631613170Harold A. ScheragaKuo-Chen Chou, George NemethyGPCR INTERACTIONSEnergetic Approach to the Packing of alpha-Helices. 2. General Treatment of Nonequivalent and Nonregular Helices_N11 Biological Chemistry2601415014157Steen E. PedersenElliot M. RossGPCR INTERACTIONSFunctional Activation of beta-Adrenergic Receptors by Thiols in the Presence or Absence of AgonistsXG99(# Biochemistry331275712762H. Gobind KhoranaWolfgang B. Fischer, Sanjay Sonar, Thomas Marti and Kenneth J. RothschildGPCR INTERACTIONSDetection of a Water Molecule in the Active-Site of Bacteriorhodopsin: Hydrogen Bonding Changes during the Primary Photoreaction y00 D>gx^FASEB3667T.W. KleinY. Daaka and H. FriedmanCB IMMUNEImmune Cells Express Neuronal-Type Cannabinoid Receptor Genewwwww;2  gInfection and Immunity6240154020Catherine A. NewtonThomas W. Klein and Herman FriedmanCB IMMUNESecondary Immunity to Legionella pneumophila and Th1 Activity Are Suppressed by Delta-9-Tetrahydrocannabinol Injectionf]::'# Int. J. Immunopharmac16593603Kirk TrislerSteven SpecterCB IMMUNEDelta-9-Tetrahydrocannabinol Treatment Results in a Suppression of Interleukin-2-Induced Cellular Activities in Human and Murine LymphocytesG>00$! Life Sciences5412811289Thomas W. KleinSteven C. Shivers, Cathy Newton, Herman FriedmanCB IMMUNEDelta9-Tetrahydrocannabinol (THC) Modulates IL-1 Bioactivity in Human Monocyte/Macrophage Cell Linesf]-- Pharmacology Biochemistry and Behavior50141146Thomas W. KleinMichael Gibertini, Catherine Newton, Herman FriedmanCB IMMUNEIL 1Beta and TNFalpha Modulate Delta9-Tetrahydrocannabinol-Induced Catalepsy in MiceՁxDD52/- Pharmacology and Experimental Therapeutics27410011007Thomas W. KleinWeigang Zhu, Toshihisa Igarashi, Herman FriedmanCB IMMUNEDelta9-Tetrahydrocannabinol (THC) Causes the Variable Expression of IL2 Receptor Subunits.ބ{KK<841 Biochemical Pharmacology4818991908Norbert E. KaminskiWoo S. Koh, Kyu H. Yang, Michael Lee and Fay K. KesslerCB IMMUNESuppression of the Humoral Immune Response by Cannabinoids is Partially Mediated Through Inhibition of Adenylate Cyclase by a Pertussis Toxin-Sensitive G-Protein Coupled Mechanism/////|s<<)%! Eur. J. Biochem2325461Pierre CasellasSylvaine Galiegue, Sophie Mary, Jean Marchand, Danielle Dussossoy, Dominique Carriere, Pierre Carayon, Monsif Bouaboula, David Shire and Gerard LeFurCB IMMUNE/CB RECEPTORExpression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpoputlationsFFFFF,, >KLife Sciences55729734B.C. PariaX-N. Wang, and S.K. DeyCB IMMUNEEffects of Chronic Treatment with Delta 9-Tetrahydrocannabinol on Uterine Growth in the MouseF=&& Neuroendocrinol. Lett1617Laura L. MurphyVaradaraj Chandrashekar and Andrzej BartkeCB IMMUNEDelta-9-Tetrahydrocannabinol Inhibits Pulsatile Luteinizing Hormone Secretion In the Male Rat: Effect of Intracerebroventricular Norepinephrine InfusionbY//  Pharmacology Biochemistry and Behavior4810111017Laura L. MurphyJuli Gher, Richard W. Steger and Andrzej BartkeCB IMMUNEEffects of Delta9-Tetrahydrocannabinol on Copulatory Behavior and Neuroendocrine Responses of Male Rats to Female Conspecifics~uFF73/- Cellular Immunology15499108David I. KusherLaura O. Dawson, Ann C. Taylor and Julie Y. DjeuCB IMMUNEEffect of the Psychoactive Metabolite of Marijuana, Delta9-Tetrahydrocannabinol (THC), on the Synthesis of Tumor Necrosis Factor by Human Large Granular Lymphocytesja11" Pharmacology and Experimental Therapeutics267635640Thomas W. KleinCatherine Newton, Rayomond Widen and Herman FriedmanCB IMMUNEDelta9-Tetrahydrocannabinol Injection Induces Cytokine-Mediated Mortality of Mice Infected with Legionella pheumophila}II:741 FASEB3670S.C. ShiversT. W. Klein, and H. FriedmanCB IMMUNEDelata9-Tetrahydrocannabinol (THC) Increases Metabolism of Arachidonic Acid in Lipopolysaccharide Stimulated Mononuclear PhagocytesA8  gFASEB3669C.NewtonH. Friedman and T. W. KleinCB IMMUNEDelta9-Tetrahydrocannabil (THC) Decreases Cell-Mediated Immunity to Legionella Pheumophila<3  gFASEB3668W. ZhuC. Newton, H. Friedman and T. W. KleinCB IMMUNEDelta9-Tetrahydrocannabinol (THC) Increses the Stabity of IL2 Receptor Beta mRNA in LymphocytesE<  kO>U8GiSynthesis486488M. SingerC. Siegel, P.M. Gordon, A.K. Dutta, R.K. RazdanCB SYNTHESISSynthesis of (R)- and (S)-4'-Acetoxyolivetol [(R)- and (S)-5-(4'-Acetoxypentyl)-1,3-benzene-diol]: Key Intermediates in the Synthesis of Tetrahydrocannabinol DerivativesZN {Tetrahedron Letters3334433446Herbert H. SeltzmanM. Anthony Moody and Mosammat K. BegumCB SYNTHESISAllylic Substitution/Rearrangement of Cannabinoids with Trimethylsilyl Bromidei]77$  Chem.Soc.,Chem. Commun15491550Herbert H. SeltzmanF. Ivy Carroll, Jason P. Burgess, Christopher D. Wyrick and David F. BurchCB SYNTHESISSynthesis, Spectral Studies and Tritiation of the Cannabinoid Antagonist SR141716A88%! {Chromatography6545364Jamal ZahalkaRaphael Mechoulam, Shulamit Levin, and Saleh Abu-LafiCB SYNTHESISResolution of chiral cannabinoids on amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase: effects of structural features and mobile phase additives j^)) J. Heterocycle Chem.25823825Ali R. BanijamaliAlexandros MakriyannisCB SYNTHESISNovel Synthesis of (-)-trans-Delta9,11-TetrahydrocannabinolVJ44#  Biochemical Pharmacology4722432252Zhi Ming ZhengSteven SpecterCB IMMUNESuppression by Delta-9-Tetrahydrocannabinol of ZLipopolysaccharide-Induced and Intrinsic Tyrosine Phosphorylation and Protein Expression in Mouse Peritoneal MacrophagesNE77)%! Immunopharmacology28209214Itzhak WirguinRaphael Mechoulam, Aviva Breuer, Elli Schezen, Joseph Weidenfeld, Talma BrennerCB IMMUNESuppression of experimental autoimmune encephalomyelitis by cannabinoidsχ~//! Life Sciences54159170F. Rodriguez de FonsecaM. Cebeira, J.A. Ramos, M. martin and J.J. Fernandez RuizCB IMMUNECannabinoid Receptors in Rat Brain areas: Secual Differences, Fluctuations during Estrous Cycle and Chantes After Gonadectomy and Sex Steroid Replacementul33 > /2eO KProteins195572Burkhard RostChris SanderGPCR, CALCULATIONSCombining Evolutionary Information and Neural Networks to Predict Protein Secondary Structure@."" Biopolymers34529539Yuko OkamotoGPCR, CALCULATIONSDependence on the Dielectric Model and pH in a Synthetic Helical Peptide Studied by Monte Carlo Simulated Annealing8&&& Computational Chemistry16648653Frank GuarnieriStephen R. WilsonGPCR, CALCULATIONSConformational Memories and a Simulated Annealing Program That Learns: Application LTBXF55&#  Computational Chemistry1513021310Frank GuarnieriClark StillGPCR, CALCULATIONSA Rapidly Convergent Simulation Method: Mixed Monte Carlo/Stochastic DynamicsTB77($  FEBS3252933Steven A. BennerDietlin L. GerloffGPCR, CALCULATIONSPredicting the conformation of proteins Man versus machineF4""  LettersR. B. BarlowGPCR, CALCULATIONSProblems associated with the partiality of a partial agonisthhhhh, cMol. Biol.227889900Barry HonigAn-Suei Yang, Kim A. SharpGPCR, CALCULATIONSAnalysis of the Heat Capacity Dependence of Protein FoldingQ?%% Drug Metabolism and Disposition19714716D. J. HarveyN.K. BrownCB METABOLISMIn Vitro Metabolism of the Equatorial C11-Methyl Isomer of Hexahydrocannabinol in Several Mammalian SpeciesQD::.+(& Molecular Pharmacology40228234Lester M. BornheimMaria Almira CorreiaCB METABOLISMPurification and Characterization of the Major Hepatic Cannabinoid Hydroxylase in the Mouse: A Possible Member of the Cytochrome P-450IIC SubfamilyXK77%" Org. Chem.5736273631Valerie VaillancourtKim F. AlbizatiCB SYNTHESISA One-Step Method for the alpha-Arylation of Camphor. Synthesis of (-) Cannabidiol and (-)-Cannabidiol Dimethyl EtherJ>// I> p?eProteins20216226Burkhard RostChris SanderGPCR MODEL G-ZConservation and Prediction of Solvent Accessibility in Protein Families?0$$ Receptor Research14167186D. RoperE. Jacoby, P. Kruger, M. Engels, J. Grotzinger, A. Wollmer and W. StraBburgerGPCR MODEL G-ZModeling of G-Protein Coupled Receptors with Bacteriorhodopsin as a Template. A Novel Approach Based on Interaction Energy Differences u((  Theor. Biol172245258R. Peter RiekMark D. Handschumacher, Shen-Shu Sung, Ming Tan, Manuel J. Glynias, Mark D. Schluchters, Jiri Novotny and Robert M. GrahamGPCR MODEL G-ZEvolutionary Conservation of both the Hydrophilic and Hydrophobic Nature of Transmembrane Residues(( Current Opinion in Structural Biology3532540Jean-Luc PopotGPCR MODEL G-ZIntegral membrane protein structure: transmembrane a-helices as autonomous folding domainsPAAA30-, Mol. Biol.23610931104Jean-Luc PopotFadel A. Samatey, Giuseppe Zaccai, Donald M. Engelman and Catherine EtchebestGPCR MODEL G-ZRotational Orientation ofTransmembrane alpha-helices in Bacteriorhodopsinφw** Protein Chemistry13442444Bengt PerssonPatrick ArgosGPCR MODEL G-ZA New Method for Prediction of Transmembrane Segments in Multiply Aligned Sequences with ApplicationI:--  Biophysical6812701282Ilya LogunovWilliam Humphrey, Klaus Schulten, and Mordechai ShevesGPCR MODEL G-ZMolecular Dynamics Study of the 13-cis for (bR548) of Bacteriorhodopsin and Its Photocyclem^(( J. Mol. Biol.55379400B. LeeF.M. RichardsGPCR MODEL G-ZThe Interpretation of Protein Structures: Estimation of Static Accessibility>/"" Am. Chem. Soc.11855805589Harel WeinsteinFrank GuarnieriGPCR, CALCULATIONSConformational Memories and the Exploration of Biologically Relevant Peptide Conformations: An illustration for the Gonadotropin-Releasing HormoneP>//  > hSg7TIPS1367H. TimmermanGPCR INTERACTIONSCloning of the H histamine receptorOOOOO,  Chromatography A691349353Ian A. NichollsOlof Ramstrom, Klaus MosbachH BONDINGInsights into the role of the hydrogen bond and hydrophobic effect on recognition in molecularly imprinted polymer synthetic peptide receptor mimicsTK//  Biochemistry3398269830Iain A. MurrayJeremy P. Derrick, Andrew J. White, Kevin Drabble, Christopher W. Wharton and William V. ShawH BONDINGAnalysis of Hydrogen Bonding in Enzyme-Substrate Complexes of Chloramphenicol Acetyltransferarse by Infrared Spectroscopy and Site-Directed Mutagenesis(((((++ Mol. Biol.252248262Zygmunt S. DerewendaLinda Lee and Urszula DerewendaH BONDINGThe Occurrence of C-H ... O Hydrogen Bonds in ProteinsVM.. Computational Chemistry15553560Steve ScheinerJan FlorianH BONDINGVariation of Atomic Charges during Proton Transfer in Hydrogen BondsH?44&#  Med. Chem. Res.3269272R.B. WestkaemperGPCR MODEL G-ZSerotonin Receptors: Molecular Genetics and Molecular Modeling{{{{{<--- Protein Engineering8543549Harel WeinsteinNina PastorGPCR MODEL G-ZElectrostic analysis of DNA binding properties in lysine to leucine mutants of TATA-box binding proteinsJ;00! Membrane Biol.115145158Stephen H. WhiteRussell E. JacobsGPCR MODEL G-ZObservations Concerning Topology and Locations of Helix Ends of Membrane Proteins of Known StructureN?.. Protein Science414121420Sucha SudarsanamRobert F. DuBose, Carl J. MarchGPCR MODEL G-ZModeling protein loops using a dimer database]N// NeuroReport512971300Michael S. SingerGordon M. ShepherdGPCR MODEL G-ZMolecular modeling of ligand-receptor interactions in the OR5 olfactory receptorM>,, Mol. Biol.232584599Burkhard RostChris SanderGPCR MODEL G-ZPrediction of Protein Secondary Structure at Better than 70% AccuracyB3'' > .|5XiNature33129134E.J. NeerDavid E. ClaphamGPCR GENERALRoles of G protein subunits in transmembrane signallingqqqqq:.  FEBS letters132261264Eric MullenMuhammad AkhtarGPCR GENERALTopographic and Active-Site Studies on Bovine RhodopsinyyyyyB6'' Conservation Biology9782791Russell LandeGPCR GENERALMutation and ConservationTTTTT;///" Nature37013John MaddoxGPCR GENERALDoes folding determine protein configuration?VVVVV)  o Biological Chemistry26714H. Gobind KhoranaGPCR GENERALRhodopsin, Photoreceptor of the Rod Celleeeee=111   Hypertension26565Victor J. HrubyXi-Ping Ni, Robert Kesterson, Roger D. Cone and Michael H. HumphreysGPCR GENERALFunctional Evidence for Melanocortin 3 Receptors (MC3-R) in Rat Kidneywk'' o Current Biology5997999Mark J.S. HeathRene HenGPCR GENERALGenetic insights into serotonin functionhhhhh@4,,  Angew.Chem.Int.Ed. Engl.3414061419Alfred G. GilmanGPCR GENERALG Proteins and Regulation of Adenylate Cyclase (Nobel Lecture)E999)%!  Biochem238625642John B. C. FindlayDarryl J.C. PappinGPCR GENERALThe opsin Family of proteinscccccG;)) Nature293314316John B. C. FindlayMichael Brett, Darryl J. C. PappinGPCR GENERALPrimary structure of C-terminal functional sites in ovine rhodopsinVJ((  Endothelin InhibitorsStephen A. DouglasGPCR GENERALNovel receptor antagonists welcome a new era in endothelin biology|||||:... cCardiovascular Pharmacology12S5S7Camilla MauzyLan-Hsin Wu, Ann Marie Egloff, Taraneh Mirzadegan, and Fu-Zon ChungMUTATIONSubstitution of Lysine-181 to Aspartic Acid in the Third Transmembrane Region of the Endothelin (ET) Type B Receptor Selectively Reduces Its High-Afinity Binding with ET-3 Peptide33333x55(&$"  >aHf]d'Molecular Pharmacology46823831Dianne M. PerezMichael T. Piascik, Niveen Malik, Robert Gaivin and Robert M. GrahamGPCR CLONESCloning, Expression, and Tissue Distribution of the Rat Homolog of the Bovine alpha1c-Adrenergic Receptor Provide Evidence for Its Classification as the alpha1A Subtype+++++x44%" Science24616201622Marc ParmentierFrederick Libert, Carine Maenhaut, Anne Lefort, Catherine Gerard, Jason Perret, Jacqueline Van Sande, Jacques E. Dumont, Gilbert VassartGPCR CLONESMolecular Cloning of the Thyrotropin Receptor軰(( Molecular Pharmacology4511911197Richard R. NeubigSusan M. Wade, Hiroko Mori Dalman, Shang-Zhao YangGPCR CLONESMultisite Interactions of Receptors nd G Proteins: Enhanced Potency of Dimeric Receptor Peptides in Modifying G Protein Functionuj88'# Biological Chemistry2701891018916Yves BoieNicole Sawyer, Deborah M. Slipetz, Kathleen M. Metters, and Mark AbramovitzGPCR CLONESMolecular Cloning and Characterization of the Human Prostanoid DP Receptorч|11(# Current Opinion in Biotechnology5372380Burkhard RostChris SanderGPCR GENERALStructure prediction of proteins-where are we now?SG;;.+(' Endocrine Reviews16427442Terry ReisineGraeme I. BellGPCR GENERALMolecular Biology of Somatostatin ReceptorsrrrrrG;--  Neuropharmacology33319324S. J. PeroutkaT.A. HowellGPCR GENERALThe Molecular Evolution of G Protein-coupled Receptors: Focus on 5-Hydroxytryptamine ReceptorsE9..  Biological Chemistry2682319123196Jean-Pierre PaccaudWalter Reith, Birgitta Johansson, Karl-Eric Magnusson, Bernard Mach and Jean-Louis CarpentierGPCR GENERALClathrin-coated Pit-mediated Receptor Internalization٤;;(# > 0BQe#Med. Chem. Res.4424431Ikuo FujiiHaruki Nakamura, Takeshi Sagara, and Ken KanematsuCGCR MODEL A-HMolecular Model Building of Multiple Opioid Receptor SubtypeshY'' "D. DonnellyJ.B.C. FindlayCGCR MODEL A-HThe Superfamily: Molecular ModellingTTTTT/  a!Protein Science3557566George W. DombiJeannette LawrenceGPCR MODEL A-HAnalysis of protein transmembrane helicalvvvvvM>,,  EMBO5823826Cyrus ChothiaArthur M. LeskGPCR MODEL A-HThe relation between the divergence of sequence and structure in proteins<-  Molecular Simulation10151174Robert E. BruccoleriGPCR MODEL A-HApplication of Systematic Conformational Search to Protein ModelingF777#  Amer. Chem. Soc.209236K. BobrowskiJ. Poznanski, J. Holeman, and K.L. WierzchowskiGPCR MODEL A-HLong Range Electron Transfer Between Proline-Bridged Aromatic Amino AcidsgX)) oBiochemistry and Molecular Biology Interantional32933939CJ BeischelK Gray, ES Hazard III, DR Knapp and RK CrouchGPCR MODEL A-HEvaluation of Photoaffinity Labeled Sites of Bacteriorhodopsin Using Molecular Modeling݆wJJ?<97 Mol. Biol.193693707D. AltschuhA.M. Lesk, A.C. Bloomer and A. KingGPCR MODEL A-HCorrelation of Co-ordinated Amino Acid Substitutions with Function in Viruses Related to Tobacco Mosaic VirusWH%% Protein Engineering2193199D. AltschuhT. Vernet, P. Berti, D. Moras and K.NagaiGPCR MODEL A-HCoordinated amino acid changes in homologous protein familiesdU,,! Molecular Pharmacology47730737Maria L. WebbChia-Ching Chao, Marguerite Rizzo, Robert A. Shapiro, Michael Neubauer, Eddie C.K. Liu, Catherine R. Aversa, Russell J. Brittain and Brent TreigerGPCR CLONESCloning and Expression of an Endothelin Receptor Subtype B from Human Prostate that Mediates Contraction7777722%" E>FW]*Biological Chemistry2702001120019William R. MoyleLaurey Cosowsky, S.N. Venkateswara Rao, Gordon J. Macdonald, Harold Papkoff and Robert K. CampbellCOUPLINGThe Groove between the alpha and Beta-Subunits of Hormones with Lutropin (LH) Activity Appears to Contact the LH Receptor, and Its Conformation Is Changed during Hormone BindingTTTTT88(# )Biological Chemistry2682373523738Robert J. LefkowitzJames Inglese, Neil J. Freedman, Walter J. KochCOUPLINGStructure and Mechanism of the G Protein-coupled Receptor Kinasesrj;;(# (Biological Chemistry2682704627062Gobind KhoranaKenneth J. Rothschild, Thomas Marti, Sanjay Sonar, Yi-Wu He, Parshuram Rath, Wolfgang FischerCOUPLINGAsp96 Deprotonation and Transmembrane alpha-Helical Structural Changes in Bacteriorhodopsin66(# 'Cellular Signalling5505518Karen E. HedinKevin Duerson and David E. ClaphamCOUPLINGSpecificity of Receptor-G Protein Interactions: Searching for the Structure Behind the SignalYQ//! &Hypertension2658Watary HayashidaMasatsugu Horiuchi, Victor J. DzauCOUPLINGIntracellular Third Loop Domain of Angiotensin II Type-2 Receptor: Unique Role in the Cellular Signal Transduction and Functional ExpressionQI'' o%Current Opinion in Structural Biology4566573Wayne L. HubbellChristian AltenbachCGCR MODEL A-HInvestigation of structure and dynamics in membrane proteins using site-directed spin labelingeVCC30-, $Mol. Biol.198425443J.F. GibratJ. Garnier and B. RobsonCGCR MODEL A-HFurther Developments of Protein Secondary Structure Prediction Using Information Theory New Parameters and Consideration of Residue PairsL=%% M> -4DHi3Neurotoxicology and Teratology172530Allyn C. HowlettRusoun C. Belue, Tracy M. Westlake and Donald E. HutchingsCB RECEPTORThe Ontogeny of Cannabinoid Receptors in the Brain of Postnatal and Aging Rats΀u;;+)'% 2Biochem. Soc. Symp.592750Steven R. ChildersMary A. Pacheco, Barbara A. Bennett, Thomas A. Edwards, Robert E. Hampson Jian Mu and Sam A. DeadwylerCB RECEPTORCannabinoid receptors: G-protein-mediated signal transduction mechanisms룘22  1Neuroscience Letters174101104Hiroshi KnoshitaTakaaki Hasegawa, Tsutomu Kameyama, Ikuo Yamamoto, Toshitaka NabeshimaSARCompetitive NMDA antagonists enhance the catalepsy induced by delta 9-tetrahydrocannabinol in mice}z44$! 0Physiology & Behavior57177179F. Molina-HolgadoM.I. Gonzalez and M. L. LeretCB PHARMACOLOGYEffect of Delta-9-Tetrahydrocannabinol on Short-Term Memory in the RataR55$! /Phys. Chem.991450614513Andrey A. BliznyukJill E. GreadyMM SOLVATIONA New Approach to Estimation of the Electrostatic Component of the Solvation Energy in Molecular Mechanics CalculationsJ>00 .Biochemistry2460726077Cary P. MoxhamCraig C. MalbonMUTATION/DISULFIDEFat Cell Beta1-Adrenergic Receptor: Structural Evidence for Existence of Disulfide Bridges Essential for Ligand BindingL:++ -Current Biology3683686Carol J. WilsonMeredithe L. AppleburyCOUPLING/MUTATION DISULFIDEArresting G-protein coupled receptor activity]B,, ,Current Biology5107109Elliot M. RossCOUPLINGPalmitoylation in G-protein signaling pathwaysaaaaa3+++ +Biological Chemistry2702002020031William R. MoyleRobert K. Campbell, S.N. Venkateswara Rao, Nagi G. Ayad, Michael P. Bernard, Yi Han, and Yanhong WangCOUPLING/GPCR MODEL/GPCR SIGNAL TRANSDUCTIONModel of Human Chorionic Gonadotropin and Lutropin Receptor Interaction That Explains Signal Transduction of the Glycoprotein HormonesOOOOOɝ88(# >*;Inves. Opth Vis. Sci341488A. Bar-LianH. Aviv, D. Friedman, M. Vered, M. Belkin, S. Amselem, H.Baru, M. Beilin, E. Wellner, Y. Wolf, J. Schwarz R. NeumanAAEImproved Performance of Ocular Drugs Formulated in Submicron Emulsions.颟,,!! o:European J. of Pharmacology264371377Angelika RichterWolfgang LoscherAAI SAR(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamstersRK;;+(%" 9Hetero. Chem.3113531359D. HeberTh. BerghausCB SYNTHESISSynthesis of 5H-[1]Benzopyrano[4,3-b]pyridin 5-ones Containing an Azacannabinoidal Structure>2&& 8European Journal of Pharmacology280R13R15Michael WalkerKang Tsou, Saundra L. PatrickCB RECEPTORPhysical withdrawal in rats tolerant to Delta9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonistf[>>0-*' 7Br. J. Pharmacol116S45pR.G. PertweeA.A. Coutts, S.R. Fernando, G. Griffin, J.E. NashCB RECEPTOREvidence that Guinea-Pig Small Intestine Contains CB1 Cannabinoid Receptors and Possibly Also a Cannabinoid Receptor Ligandf[** o6Proc. Nat. Acad. Sci.9294609464B.C. PariaS.K. Das and S.K. DeyCB RECEPTORThe preimplantation mouse embryo is a target for cannabinoid ligand-receptor signalingPE00&" 5Pharmacology Biochemistry and Behavior46295301Alexandros MakriyannisBilly R. Martin, David R. Compton, Simon F. Semus, Sonyuan Lin, Gilbert Marciniak, Jolanta Grzybowska, Avgui CharalambousCB RECEPTORPharmacological Evaluation of Iodo and Nitro Analogs of Delta8-THC and Delta9-THC KK52/- 4Neuroscience1565526661K. MackieY. Lai, R. Westenbroek and R. MitchellCB RECEPTORCannabinoids Activate an Inwardly Rectifying Potassium Conductance and Inhibit Q-Type Calcium Currents in At T20 Cells Transfected with Rat Brain Cannabinoid ReceptorWL&& > GSvMDBiochem J.223533542Gary E. R. HookJudson W. Spalding, Mary J. Ortner, Elieas G. Tombropoulos and Colin F. ChignellLIPIDSInvestigation of phospholipids of the pulmonary extracellular lining by electron paramagnetic resonancey)) CBrain Research626272277Bao Gang XueJames D. Belluzzi and Larry SteinCBIn vitro reinforcement of hippocampal bursting by the cannabinoidMK** BStructural Biology1173644Gebhard F.X. SchertlerBrent E. Gowen, Helen R. SaibilGPCR MODELProjection Structure of an Inertebrate Rhodopsin_U66  AProc. Natl. Acad. Sci.921157811582Gebhard F.X. SchertlerPaul A. HargraveGPCR MODELProjection structure of frog rhodopsin in two crystal formsYO??)$ @J. Med. Chem.39471479Brian F. ThomasIrma B. Adams, S. Wayne Mascarella, Billy R. Martin, and Raj K. RazdanAEAStructure-Activity Analysis of Anandamide Analogs: Relationship to a Cannabinoid Pharmacophoretq++ ?Neuron14825831Jonathan A. JavitchDingyi Fu, Jiayun Chen, and Arthur KarlinGPCK MODELINGMapping the Binding-Site Crevice of the Dopamine D2 Receptor by the Substituted-Cysteine Accessibility Method.^Q((  >Brain Research694223232J. RomeroR. de Miguel, E. Garcia-Palomero, J.J. Fernandez-Ruiz, J.A. RamosAEATime-course of the effects of anandamide, the putative endogenos cannabinoid receptor ligand, on extrapyramidal functionkh'' =Current Eye Research14791797David W. PateKristina Jarvinen, Arto Urti, Pekka Jarho and Tomi JarvinenAAEOphthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbitsnk00#  <Prostaglandius Leukotrienes & Essential Acids53301308A FontanaV.Di Marzo, H. Cadas and D. PiomelliAEAAnalysis of Anandamine, an Endogeous Cannabinoid Substance, and of Other Natural N-AcylethanolaminesliEE<964 > 7}LBiological Chemistry2692338323386Roman OsmanJeffrey H. Perlman, Liisa Laakkonen, and Marvin C. GershengornGPCR ModelA Model of the Thyrotropin-releasing Hormone (TRH) Receptor Binding Pocket{q33(# KMolecular Structure (Theochem)306157164Jaroslav KocaZdenek Kriz, Per H.J. CarlsenGPCR, MODELSComputer study of conformational flexibility of 20 common amino acidsdX;;.+(% JReceptors and Channels2107119D. TimmsA.J. Wilkinson, D.R. Kelley, K.J. Broadley and R.H. DaviesGPCR MODELLigand-Activated Trans-Membrane Proton Transfer in Beta1-Adrenergic and m2-Muscarinic Receptorspf,,$! IProtein Chemistry14381398M.-P.JosephB. Maigret, J.C. Bonnafous, J. Marie, and H.A. ScheragaGPCR MODEL/COUPLINGA Computer Modeling Postulated Mechanism for Angiotensin II Receptor Activationub++  HBioorganic & Medicinal Chemistry2195211Francesca FanelliM. Cristina Menziani, Angelo Carotti and Pier G. De BenedettiGPCR MODELTheoretical Quantitative Structure-Activity Relationship Analysis On Three Dimensional Models Of Ligand-m1 Muscarinic Receptor Complexes}??.+(' GMolecular Structure (Theochem)3334969F. FanelliM.C. Menziani, M. Cocchi, P.G. De BenedettiGPCR MODELComparative molecular dynamics study of the seven-helix bundle arrangement of G-protein coupled receptorska66,*(% FTetrahedron: Asymmetry524592473Michael J. CostanzoHarold R. Almond, Jr., A Diane Gauther, and Bruce E. MaryanoffCONFORMATIONNon-Chair Six-Membered-Ring Conformations. Preference for a Twist-Boat (or Skew) Structure in alpha-L-Sorbopyranose Derivativesw99&" EBiophysical69965973Edward M. GoldbergDavid S. Lester, Dan B. Borchardt and Raphael ZidovetzkiLIPIDEffects of Diacylglycerols on Conformation of Phosphatidylcholine Headgroups in Phosphatidylcholine/Phosphatidylserine Bilayersid,, >2D1rTEuropean J. of Pharmacology306195210Svein G. DahlKurt KristiansenGPCR MODELMolecular modeling of serotonin, ketanserin, ritanserin and their 5-HT2c receptor interactionsRH88+(%" SMolecular Pharmacology4910921096Roman OsmanLiisa Laakkonen, Wenhao Li, Jeffrey H. Perlman, Frank Guarnieri, Kevin D. Moeller, and Marvin C. GershengornGPCR MODELRestricted Analogues Provide Evidence of a Biologically Active Conformation of Thyrotropin-Releasing Hormone22'# RBiological Chemistry2711506015068Yuan-Ping PangBernadette Cusack, Karen Groshan, and Elliott RichelsonGPCR MODELProposed Ligand Binding Site of the Transmembrane Receptor for Neurotensin(8-13)wm66(# QMolecular Pharmacology38939949Robert F. BrunsJames H. FergusGPCR MODELSAllosteric Enhancement of Adenosine A1 Receptor Binding and Function by 2-Amino-3-benzoylthiophenesNC44%" PQSAR and Molecular Modelling: Concepts497507H. WeinsteinD. ZhangGPCR MODELSReceptor Models and Ligand-Induced Responses: New Insights for Structure-Activity RelationsRG??30-- {OMed. Chem3935033513Martin H. HedbergTero Linnanen, Johanna M. Jansen, Gunnar Nordvall, Stephan Hjorth, Lena Unelius, and Annette M. JohanssonGPCR MODELS11-Substituted (R)-Aporphines: Pharmacology, and Modeling of D2A and 5-HT1A Receptor Interactions++ NEuropean J. of Pharmacology304173183Cecil NavajasTarja Kokkola, Antti Poso, Nina Honka, Jukka Gynther, Jarmo T. LaitinenGPCR MODELA rohodopsin-based model for melatonin recognition at its G protein-coupled receptor݉88+(%" MBiochemistry3334573463Constance J. JefferyD.E. Koshland, Jr.GPCR MODELA Single Hydrophobic to Hydrophobic Substitution in the Transmembrane Domain Impairs Aspartate Receptor FunctionMC11 R> CLjn]Proc. Natl. Acad. Sci.9316James A. WellsINTERACTIONS/THERMOBinding in the growth hormone receptor complexpppppB///!  \Biochemistry331397713988Sandor VajdaZhiping Weng, Rakefet Rosenfeld, and Charles DeLisiThermodynamicsEffect of conformational flexibility and solvation on Receptor-Ligand Binding Free Energiesl^++ [Vasumati K. PestonjamaspSumner H. BursteinAEATHC - Stimulated Metabolism of Ethanolamine and Arachidonic Acid in Cells of Peripheral Origin41 aZExperientia44762764R. MechoulamJ. J. Feigenbaum, J.J. Feigenbaum, N. Lander, M. Segal, T.U. C. Jarbe, A. J. Hiltunen and P. ConsroeSAREnantiomeric cannabinoids: sterospecificity of psychotropic activityэ&& YBiochemical Pharmacology46791796Dale G. DeutschSuzette A. ChinAEAEnzymatic Synthesis and Degration of Anandamine, a Cannabinoid Receptor AgonistHE66'$! XScience25819461949William A. DevaneLumir Hanus, Aviva Breuer, Rogert G. Pertwee, Lesley A. Stevenson, Graeme Griffin, Dan Gibson, Asher Mandelbaum, Alexander Etinger, Raphael MechoulamtAEAIsolation and Structure of a Brain Constitutent That Binds to the Cannabinoid Receptor** WBiochemical and Biophysical Research Communication2168997Takayuki SugiuraSachiko Kondo, Akihiro Sukagawe, Shinji Nakane, Akira Shinoda, Kiyoko Itoh, Atsushi Yamashita and Keizo WakuAEA2-Arachildonoylgycerol: A possible endogenous cannabinoid receptor ligand in brainPP@><9 VScience271163168Dennis A. DoughertyGPCR INTERACTIONSCation- Pi Interactions in Chemistry and Biology: A new view of Benzene, Phe, Tyr, and Trp;*** UTetrahedron Asymmetry524592473Michael J. ConstanzoHarol R. Almond, Jr., A. Diane Gauthier and Bruce E. MaryanoffConformationNon-Chair Six-Membered-Ring Conformations. Preference for a Twist-Boad (or Skew) Structure in alpha-L-Sorbopyranose Derivativesw99%! >-o3dAm. Chem. Soc.1141069710704Mark S. SearleDudley H. Williams, and Ute GerhardINTERACTIONS/THERMOPartitioning of Free Energy Contributions in the Estimation of Binding Constants: Residual Motions and Consequences for Amide-Amide Hydrogen Bond StrengthsfS00" cAm. Chem. Soc.1141069010697Mark S. SearleDudley H. WilliamsINTERACTIONS/THERMOThe Cost of Conformational Order: Entropy Changes in Molecular AssociationsUB00" bAm. Chem. Soc.114338343Andrew J. DoigDudley H. WilliamsINTERACTIONS/THERMOBinding Energy of an Amide-Amide Hydrogen Bond in Aqueous and Nonpolar SolventsQ>,, aBiochemical Society Transactions24143SMikael PerakylaTapani A. PakkanenINTERACTIONS/THERMOQuantum mechanical model assembly calculations of energetics of binding of ligands to protein receptorsaN<<--)' o`Proc. Natl. Acad. Sci.9119641968Patrick R. ConnellyRobert A. Aldape, Frank J. Bruzzese, Stephen P. Chambers, Matthew J. Fitzgibbon, Mark A. Fleming, Susumu Itoh, David J. Livingston, Manuel A. Navia, John A. Thomson, and Keith P. WilsonINTERACTIONS/THERMOEnthalpy of hydrogen bond formation in a protein-ligand binding reactionNNNNN::'# _Am. Chem. Soc.11370207030Dudley H. WilliamsJonathan P.L. Cox, Andrew J. Doig, Mark Gardner, Ute Gerhard, Perry T. Kaye, Allick R. Lal, Ian A. Nicholls, Colin J. Salter and Robert C. MitchellINTERACTIONS/THERMOToward the Semiquantitative Estimation of Binding Constants. Guides for Peptide-Peptide Binding in Aqueous SolutionLLLLL22  ^Proc. Natl. Acad. Sci.816781683Michael I. PageWilliam P. JencksINTERACTIONS/THERMOEntropic Contributions to Rate Accelations in Enzymic and Intramolecular Reactions and the Chelate EffectYF55&" >PkMolecular Structure380195204Bogumil BrzezinskiGeorg ZundelINTERACTION H BondsFormation of hydrogen-bonded chains between a strong base with guanidine-like character and phenols with various pKa values - an FT-IR studyUA55#  jBiochemistry3594609468J.C. TongL.Q. Zhu and F.Y. YangINTERACTION THERMOV92A Mutation Altered the Folding Propensity of Chicken Apocytochrome c and Its Interaction with PhospholipidsN<&& iNature302528532Masaharu NodaHideo Takahashi, Tsutomu Tanabe, Mitsuyoshi Toyosato. Sho Kikyotani, Yasuji Furutani, Tadaaki Hirose, Hideaki Takashima, Seiichi Inayama, Takashi Miyata, and Shosaku NumaINTERACTION THERMOStructural homology of Torpedo californica acetylcholine recepotr subunits)))))##  hScience27297101Shu-ou ShanStewart Loh, Daniel HerschlagINTERACTION THERMOThe Energetics of Hydrogen Bonds in Model Systems: Implications for Enzymatic CatalysisP>!! g837846Christopher A. HunterJuswinder Singh and Janet M. ThorntonINTERACTION THERMOPi-Pi Interactions: the Geometry and Energetics of Phenylalanine-Phenylalanine Interactions in ProteinsYG""  yfAm. Chem. Soc.11855625571Yasuhiro AoyamaKen Endo, Takashi Anzai, Yuji Yamaguchi, Tomoya Sawaki, Kenji Kobayashi, Nobuko Kanehisa, Hiroshi Hashimoto, Yasushi Kai, and Hideki MasudaINTERACTION THERMOCrystal Engineering of Stacked Aromatic Columns. Three-Dimensional Control of the Alignment of Orthogonal Aromatic Triads and Guest Quinones via Self-Assembly of Hydrogen-Bonded Networks̺//  eProc. Natl.Acad.Sci.9011721178Dudley H. WilliamsMark S. Searle, Joel P. Mackay, Ute Gerhard, and Rachel A. MaplestoneINTERACTION THERMOToward an estimation of binding constants in aqueous solution: Studies of associations of vancomycin group antibiotics|77%! >5+uGasComputational Chemistry11868895Norman L. AllingerFanbing Li, and Liqun Yan, Julia C. 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AllingerMM CALCULATIONSMolecular Mechanics (MM3) Study of the Structures and Energetics of Corannulene (C20H10), Cyclopentacorannulene (C22H12) and the Hemi-spherical C30H10bS33(%"! nMolecular Structure381914D. HadziJ. Grdadolnik, A. MedenINTERACTION HYDROGEN BONDINGInfrared spectra of, and hydrogen bonding in acid palmitates\?((  mVibrational Spectroscopy1293102R.A. NyquistC.L. Putzig, T.I. Clark, A.T. McDonaldINTERACTION HYDROGEN BONDING/GPCRInfrared study of intramolecularly hydrogen bonded aromatic carbonyl containing compounds in various solventszX22&#! lMolecular Structure381107125Zofia Dega-SzafranAnna Kania, Monika Grundwal-Wyspianska, Miroslaw Szafran, Ewa TykarskaINTERACTION H BONDINGDifferences between the N.H.O and O.H. O hydrogen bonds in complexes of 2,6-dichloro-4-nitrophenol with pyridines and pyridine N-oxides{55#  H> \gOf}Am. Chem. Soc.11265306536R.F. W. BaderJ.R. Cheeseman, K.E. Laidig, K.B. Wiberg, and C. BrenemanMM CALCULATIONSOrigin of Rotation and Inversion Barriersuf--  |Ame. Chem.Soc.114116P. ApedN. L. AllingerMM CALCULATIONSA Molecular Mechanics Study of Cyclopropanes within the MM2 and MM3 Force Fields?0"" {Computational Chemistry34046Ulrich BurkertNorman L. AllingerMM CALCULATIONSPitfalls in the Ude of the Torsion Angle Driving Method for the Calculation of Conformational InterconversionsRC11#! zAm. Chem. Soc.11345054517Norman L. AllingerKuohsiang Chen, Mita Rahman, and Ahammadunny PathiaserilMM CALCULATIONSMolecular Mechanics (MM3) Calculations on Aldehydes and Ketonesyj22  yAm. Chem. Soc11185518575Norman L. AllingerYoung H. Yuh, and Jenn-Huei LiiMM CALCULATIONSMolecular Mechanics. The MM3 Force Field for Hydrocarbons. 1_P11 xIsrael Jornal of Chemistry205156Norman L. AllingerScott H. M. Chang, Donna Hindman Glaser and Helmut HonigMM CALCULATIONSAn Improved Molecular Mechanics Force Field for Alcohols and EthersÀq99'%#! wTetrahedron4680058018Soo Gyeong ChoFrank K. Cartledge, Rayomand J. Unwalla and Salvatory , Jr.MM CALCULATIONSDeveopment of a Molecular Mechanics (MM2) Force Field for alpha-Chlorosilaneste** vComputational Chemistry15866874J. Phillip BowenGuyan Liang, James A. BentleyMM CALCULATIONSMolecular Mechanics (MM3) Parameterization of Hydroxylamine and Methyl DerivativesbS66&#  uAm. Chem. Soc.11185768582Jenn-Huei LiiNorman L. AllingerMM CALCULATIONSMolecular Mechanics. The MM3 Force Field for Hydrocarbons. 3. The van der Waals' Potentials and Crystal Data for Aliphatic and Aromatic HydrocarbonsN?--  tComputational Chemistry11848867Norman L. AllingerFabing Li, and Kiqun YanMM CALCULATIONSMolecular Mechanics, The MM3 Force Field for Alkenes_P88&#  > ~8Am. Chem. Soc.11658875897Henry D. ThomasKuohsiang Chen and Norman L. AllingerMM CALCULATIONSToward A Better Understanding of Covalent Bonds: The Molecular Mechanics Calculation of C-H Bond Lengths and Stretching FrequenciescT//  Computational Chemistry7528538Salvatore Profeta, Jr.Rayomand J. Unwalla, Benh T. Nguyen and Frank K. CartledgeMM CALCULATIONSA Comparison of the Rotational Potential Functions in Butane, Propylsilane, Ethylmethylsilane, and 1,2-Disilylethane: Ab Initio and MM2 Resultsu;;%" Tetrahedron4938793898Hanoch SenderowitzPinchas Aped and Bension FuchsMM CALCULATIONSComputation of O-C-F and N-C-F Systems: AB-initio Calculation and a MM2 Parameterization Study Theory vs Experiment[L.. Org. Chem5659085911J. Jens WoffStephen F. Nelsen, and Douglas R. PowellMM CALCULATIONSBoat and Twist-Boat Structures of 2,3,6- Tris (isopropylamino)-1,3,5-trinitrobenzene: Conformational Change through Intermolecular Hydrogen Bonding]N&& Am.Chem.Soc11379177924Jan H. JensenMark S. GordonMM CALCULATIONSThe Conformational Potential Energy Surface of Glycine: A Theoretical StudyG8** Tetrahedron3828112819Helena DodziukHubertus Von Voithenberg and Norman L. AllingerMM CALCULATIONSA Molecular Mechanics Study of Methyl Vinyl Ether and Related CompoundshY** Molecular Structure (Theochem)188149157E. GoldsteinN.L. AllingerMM CALCULATIONSMolecular Mechanics Calculation (MM2) on Aliphatic NitrilesVG::.+(% ~Org. Chem.5353635366Josep CastellsCarlos Jaime, Francisco Lopez-Calahorra, Nuria Santalo and Dolores VelascoMM CALCULATIONSParameterization of Cyano Group MM2 Constants in Peracetylated Aldononitrilesςs)) E> ~UaAm. Chem. Soc.11782118219Frank GuarnieriHanoch Senderowitz, and W. Clark StillGPCR CALCULATIONSA Smart Monte Carlo Technique for Free Energy Simulations of Multiconformational Molecules. Direct Calculations of the Conformational Populations of Organic Molecules fU//  Computational Chemistry12186199Jenn-Huei LiiNorman L. AllingerMM CALCULATIONSThe MM3 Force Field for Amides, Polypeptides and ProteinsTE33&#  Org. Chemistry5113411346Bruce E. MaryanoffDavid F. McComsey, Harold R. Almond, Jr., and Martin S. MutterMM CALCULATIONSDramatic Reversal of Diastereoselectivity in an N-Acyliminium Ion Cyclization Leading to Hexahydropyrrolo[2,1-a]isoquinolines. A Case of Competing Steric Interactions%%%%%~o11 Am. Chem. Soc.10719071918S. Profeta, Jr.N.L. AllingerMM CALCULATIONSMolecular Mechanics Calculations on Aliphatic AminesK[:Biochemistry3488128819Zohreh Toossi FarahabakhshKevin D. Ridge, H. Gobind Khorana, and Wayne I. HubbellGPCR MODELMapping Light-Dependent Structural Changes in the Cytoplasmic Loop Connecting Helices C and D in Rhodopsin: A Site-Directed Spin Labeling Studyxn77 Nature383347350Henry R. BourneSoren P. Sheikh, Tatyana A. Zvyaga, Olivier Lichtarge, Thomas P. SakmarMUTATION, COUPLINGRhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F~l%%  Biochemistry351127811285Harel WeinsteinDingyi Fu, Juan A. Ballesteros, Jiayun Chen, and Jonathan A. JavitchGPCR MODELS, MUTATIONResidues in the Seventh Membrane-Spanning Segnment of the Dopamine D2 Receptor Accessible in the Binding-Site Crevices.. Mathematical Chemistry182535Frank GuarnieriTheory and algorithms for mixed Monte Carlo-stochastic dynamics simulations}}}}}2222#! Medicinal Chemistry3945154519Alexandros MakriyannisAtmaran D. Khanolkar, Vasiliki Abadji, Sonyuan Lin, W. Adam G. Hill, Gihan Taha, Khaled Abouzid, Zhaoxing Meng, Pushen FanANNANDAMIDEHead Group Analogs of Arachidonylethanolamide, the Endogenous Cannabinoid Ligand::$  Biochemistry3576517663Frank GuarnieriLiisa J. Laakkonen, Jeffrey H. Perlman, Marvin C. Gershengorn and Roman OsmanGPCR CALCULATIONSA Refined Model of the Thyrotropin-Releasing Hormone (TRH) Receptor Binding Pocket. Novel Mixed Mode Monte Carlo/Stochastic Dynamics Simulations of the Complex between TRH and TRH Receptor.HHHHHy,, Biochemistry3576437650Frank GuarnieriJeffrey H. Perlman, Liisa J. Laakkonen, Roman Osman and Marvin C. GershengornGPCR CALCULATIONSA Refined Model of the Thyrotropin-Releasing Hormone (TRH) Receptor Binding Pocket. Experimental Analysis and Energy Minimization of the Complex between TRH and TRH Receptor.99999y,, 7>N}QMedicinal Chemistry3938753877John W. HuffmanShu Yu, Vincent Shwalter, Mary E. Abood, Jenny L. Wiley, David R. Compton, Billy R. Martin, R. Daniel Bramblett, and Patricia H. ReggioCBSAR, CB ReceptorSynthesis and Pharmacology of a Very Potent Cannabinoid Lacking a Phenolic Hydroxyl with High Affinity for the CB2 ReceptorGGGGG̺33$  Molecular Pharmacology49891896Zhao-Hui SongTom I. BonnerCB RECEPTORA Lysine Residue of the Cannabinoid Receptor Is Critical for Receptor Recognition by Several Agonists but not WIN55212-2J?22%" JPET278989999Vincent M. ShowalterDavid R. Compton, Billy R. Martin and Mary E. AboodCB RECEPTOR SAREvaluation of Binding in a Transfected Cell Line Expressing a Peripheral Cannabinoid Receptor (CB2): Identification of Cannabinoid Receptor Subtype Selective Ligandsj[((  European J. of Pharmacology284241247John W. HuffmanRoger G. Pertwee, Graeme Griffin and Julia A.H. LaintonAAIPharmacological Characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferenstq::+(%" Med Chem3919671974Allyn C. HowlettKoichiro Yamada, Kenner C. Rice, Judith L. Flippen-Anderson, Michael A. Eissenstat, Susan J. Ward, M. Ross JohnsonAAI/CB RECEPTOR(Aminoalkyl)indole Isothiocyanates as Potential Electrophillic Affinity Ligands for the Brain Cannabinoid Receptor)) Organic Chemistry35521523Karst HoogsteenNelson R. TrennerAAIsThe Structure and Conformation of the cis and trans Isomers of 1-(p-Chlorobenzylidene)-2-methyl-5-methoxyindenylacetic AcidD@//  Biochemistry311259212601George B. CohenDaniel D. Oprian and Phyllis R. RobinsonGPCR MODELMechanism of Activation and Inactivation of Opsin: Role of Glu113 and Lys296`V.. Biochemistry3272297236Karim FahmyThomas P. SakmarGPCR MODEL Regulation of the Rhodopsin-Transducin Interaction by a Highly Conserved Carboxylic Acid GroupB8(( >$0  Am.Chem.Soc.11669296930Johannes J. VoegelSteven A. BennerH BONDINGNonstandard Hydrogen Bonding in Duplex Oligonucleotides. The Base Pair between an Acceptor-Donor-Donor Pyrimidine Analog and a Donor-Acceptor-Acceptor Purine AnalogI@00 Am. Chem.Soc.11627782792Chia-Yu HuangLarry A. Cabell and Eric V. AnslynH BONDINGMolecular Recognition of Cyclitols by Neutral Polyaza-Hydrogen-Bonding Receptors: The Strength and Influence of Intramolecular Hydrogen Bonds between Vicinal AlcoholsWN,, Biological Chemistry27199029905Zvi VogelMichael Bayewitch, Man-Hee Rhee, Tomer Avidor-Reiss, Aviva Breuer, Raphael MechoulamCB RECEPTOR(-)-Delta9-Tetrahydrocannabinol Antagonizes the Peripheral Cannabinoid Receptor-mediated Inhibition of Adenylyl Cyclase//&" Biorganic & Medicinal Chemistry Letters622632268Michel GallantClaude Dufresne, Yves Gareau, Daniel Guay, Yves Leblanc, Petpiboon Prasit, Chantal Rochette, Nicole Sawyer, Deborah M. Slipetz, Nathalic Tremblay, Kathleen M. Metters and Marc LabelleCBSAR/CB RECEPTORNew Class of Potent Ligands for the Human Peripheral Cannabinoid ReceptorVVVVV EE73/. Nature2848387Benjamin F. CravattDan K. Giang, Stephen P. Mayfield, Dale L. Boger, Richard A. Lerner and Norton B. GilulaANANDAMIDEMolecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides''  Science2292328S.K. BurleyG.A. PetskoGPCR INTERACTIONSAromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization<+  Science274768770H. Gobind KhoranaDavid L. Farrens, Christian Altenbach, Ke Yang, Wayne L. HubbellCOUPLINGRequirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsinph(( > @Chem. Soc. Faraday Trans.9030653069Masafumi OkuyamaShun-Ichi IkawaH BONDINGIntramolecular Hydrogen Bond and Molecular ConformationRI::*&"  Chem. Soc. Faraday Trans.9014111414Marek IlczyszynH BONDINGNature of Hydrogen Bonds formed by Phenol Derivatives and N,N-Dimethylaniline in Aprotic Solvents: Low-temperature NMR StudiesB999*&"  Am. Chem.Soc.1151260112602Chi-Ying HungThomas Hopfer and Randolph P. ThummelH BONDINGMolecular Recognition: Consideration of Individual Hydrogen-Bonding Interactions\S..! Physical Organic Chemistry7142146T. DziembowskaB. Szczodrowska, T.M. Krygowski and S. J. GrabowskiH BONDINGEstimation of the OH ...O Interaction Energy in Intramolecular Hydrogen Bonds: A comparative studyri66(%"! Am. Che. Soc.116909915Paola GilliValerio Bertolasi, Valeria Ferretti and Gastone GilliH BONDINGConvalent Nature of the Strong Homonuclear Hydrogen Bond. Study of the O---H---O System by Crystal Structure Correlation Methodsf](( Phys. Chem.971250412508P.W. JoiremanS.M. Ohiline, L.L. Connell, and P.M. FelkerH BONDINGPicosecond Methods Applied to a Structural Study of N-H...X Hydrogen Bonds: Geometries of Carbazole-Water and Carbazole-Ammonia by Rotational Coherence Spectroscopy_V++ Molecular Structure2638794M. Dulce G. FariaJ.J.C. Teixeira-Dias and R. FaustoH BONDINGHydrogen bonding involving alpha,beta-unsaturated carboxylic esters and substituted phenols: an infrared spectroscopic]T22! Polish J. Chem.6814551489T. DziembowskaH BONDINGIntramolecular Hydrogen BondingVVVVV7...  Molecular Structure (Theochem)314229239J.C. ContadorM.A. Aguilar, M.L. Sanchez, F.J. Olivares del ValleH BONDINGA theoretical study of hydrogen-bonded complexes in solution: BSSE and decomposition of interaction energywn;;.+(% :> _*aXAm.Chem.Soc.20981T..I. SpectorM.JiunxinH BONDINGThe Hydrogen Bonding of HalophenolsZZZZZ7.%% oAm. Chem. Soc.11644954496Stephen HanessianArthur Gomtsyan, Michel Simard and Stefano RoelensH BONDINGMolecular Recognition and Self-Assembly by "Weak" Hydrogen Bonding: Unprecedented Supramolecular Helicate Structures from Diamine/Diol Motifslc11  Computational Chemistry15183189Jesus RodriguezH BONDINGSemiemprical Study of Compounds with Intramolecular O--H--O Hydrogen Bonds. II. Further Verification of a Modified MNDO Method>555&#  Bull.Soc.Chim.Beig.102693698A. Srinivasa RaoV. Arulmozhi and S.RajalakshmiH BONDINGMutual Interactions between hydrogen bonds in alcohols nuclear magnetic relaxation studyZQ33#  Acta Cryst.B51103107B. PirardG. Baudoux and F. DurantH BONDINGA Database Study of Intermolecular NH...O Hydrogen Bonds for Carboxylates, Sulfonates and Monohydrogen PhosphonatesE<$$ Tetrahedron Letters3540774080Steven C. ZimmermanThomas J. MurrayH BONDINGHydrogen Bonded Complexes with the AA.DD,AA.DDD, and AAA.DD Motifs: The Role of Three Centered (Bifurcated) Hydrogen BondingPG77$  Chem. Soc. Rev.16467498A.C. LegonH BONDINGAngular Geometries and other Properties of Hydrogen-bonded Dimers: A Simple Electrostatic Interpreatation of the Success of the Electron-pair Model1((( Am. Chem. Soc.11624932499Peter A. KollmanIan R. GouldH BONDINGTheoretical Investigation of the Hydrogen Bond Strengths in Guanine-Cytosine and Adenine-Thymine Base PairE<00  Org. Chem.5866926700Kenji KogaKei Manabe, Kimio Okamura Tadamasa DateH BONDINGReceptors for Oxo Acids: Effects of Intra-Ion-Pair Hydrogen Bonding on Acid-Base EquilibriaUL%% Mol. Biol.2418393Z.S. DerewendaU. Derewenda, and P.M. KudosH BONDING(His)C-H...O=C,Hydrogen Bond in the Active Sites of Serine HydrolasesKB&& > >0eChem.Soc.,Chem.Commun23412342Thomas SteinerH BONDINGEffect of Acceptor Strength on C-H...O Hydrogen Bond Lengths as revealed by and quantified from Crystallographic Data;222$  {Molecular Structure3228391N.S. GolubevG.S. Denisov, V.A. Gindin, S.S. Ligay, H.H. Limbach, S.N. SmirnovH BONDINGThe role of short hydrogen bonds in mechanisms of enzymatic actionwn--! Chem. Phys.10043474354Theresa A. RamelotCing-Han Hu, Joseph E. Fowler, Bradley J. DeLeeuw and Henry F. Schaefer IIIH BONDINGCarbonyl-water hydrogen bonding: The H2CO-H2Oprototypez// Quantum Biology Symposium207787Xiaofeng DuanSteve Scheiner, and Rongshun WangH BONDINGModeling Proton Transfer Potentials in Angularly Deformed Hydrogen Bonds]T33&$"  Molecular Structure (Theochem)3076571Steve ScheinerH BONDINGRelationship between strength of hydrogen bond and barrier to proton transferC:::,*(% Am. Chem. Soc.11793619362Jon S. ThorsonEli Chapman, and Peter G. SchultzH BONDINGAnalysis of Hydrogen Bonding Strengths in Proteins Using Unnatural Amino AcidsXO..  Quantum Chemistry:Quantum Biology Symposium20181190Xiaofeng DuanSteve ScheinerH BONDINGBehavior of Interaction Energy and Intramolecular Bond Stretch in Linear and Bifurcated Hydrogen Bonds^UGG:742 Molecular Structure Theochem1811924Milan RemkoSteve ScheinerH BONDINGAB Initio Investigation of Hydrogen Bonding by Carbamates: Complexes Including N-Methyl Methylcarbamate, N-Phenyl Methylcarbamate, Dimethyl ether and Methyl AcetateLC55*(&# Carbohydrate Research259112Thomas SteinerWolfram SaengerH BONDINGReliability of assigning O-H ...O hydrogen bonds to short intermolecular O... O separations in cyclodextrin and oligosaccharide crystal structuresH?00"  >(S=Soc. Perkin Trans2703707Henry S. RzepaMark H. Smith and Michael L. WebbH BONDINGA Crystallographic, AM1 and PM3 SCF-MO Investigation of Strong OH... 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Fillaux, M.H. Baron, S. Bennington, J. TomkinsonH BONDINGA New Look at Proton Transfer Dynamics Along the Hydrogen Bonds in Amides and PeptidesaX%% Molecular Structure321205214Jan M. BakkeLeif H. Bjerkeseth, Tor E.C.L. Ronnow, Kjersti SteinsvollH BONDINGThe conformation of 2-fluoroethanol - is intramolecular hydrogen bonding important?qh//#  Acta CrystB50348357TH. SteinerW. SaengerH BONDINGLengthening of the Covalent O--H Bond in O--H...O Hydrogen Bonds Re-examined from Low-Temperature Neutron Diffraction Data of Organic Compounds8/%% >Molecular Pharmacology27612623David G. RhodesJ. George Sarmiento, and Leo G. HerbetteMEMBRANEKinetics of Binding of Membrane-Active Drugs to Receptor Sites Diffusion-Limited Rates for a Membrane Bilayer Approach of 1,4-Dihydropyridine Calcium Channel Antagonists to Their Active Site"""""d\44%" Biochimica et Biophysica Acta1070209214Michael R. MorrowGary A. Simatos, Rajani Srinivasan, Nestor Gradal, Lorne Taylor and Kevin M. W. KeoughMEMBRANEThe effect of changes in gramicidin conformation on bilayer lipid properties靕??.+($ Molecular Pharmacology5016051611Tung Ming FongHong Yu, Ruey-Ruey C. Huang, Margaret A. Cascieri, and Christopher J. SwainINTERACTIONS MUTATIONRelative Contribution of Polar Interactions and Conformational Compatibility to the Binding of Neurokinin-1 Receptor Antagonists55'# Molecular Pharmacology5016191624Eva V. VargaZiaoping Li, Dagmar Stropova, Teresa Zalewska, Robert S. Landsman, Richard J. Knapp, Ewa Malatynska, Kohji Kawai, Akira Mizusura, Hiroshi Nagase, Silvia N. Calderon, Kenner Rice, Victor J. Hruby, William R. Roeske and Henry I. YamamuraMUTATIONThe Third Extracellular Loop of the Human delta-Opioid Receptor Determines the Selectivity of delta-Opioid Agonists&33'# Molecular Pharmacology5016351642Hemang BarbhaiyaRebecca McClain, Adriaan Ijzerman and Scott A. RivkeesMUTATION INTERACTIONSSite-Directed Mutagenesis of the Human A1 Adenosine Receptor: Influences of Acid and Hydroxy Residues in the First Four Transmembrane Domains on Ligand Binding"""""m77'# Molecular Structure3237178Bogumil BrzezinskiPiotr Radziejewski, Jerzy Olejnik, Georg ZundelH BONDINGAn intramolecular hydrogen bonded system with large proton polarizability - a model with regard to the proton pathway in bacteriorhodopsin and other systems with collective proton motion%%%%%kb33! >Biochimica et Biophysica Acta1024336344Thomas MavromoustakosDe-Ping Yang, Avgui Charalambous, Leo G. Herbette, and Alexandros MakriyannisMEMBRANEStudy of the topography of cannabinoids in model membranes using X-ray diffractionꘐCC.+($ Medicinal Chemistry34869877R. Preston MasonDavid G. Rhodes and Leo G. HerbetteMEMBRANEReevaluting Equilibrium and Kinetic Binding Parameters for Lipophilic Drugs Based on a Structural Model for Drug Interaction with Biological Membranes]U22" Biochimica et Biophysica Acta10283142Alexandros MakriyannisDe-Ping Yang, Robert G. Griffin and Sunil K.Das GuptaMEMBRANEThe perturbation of model membranes by (-)-delta-9-tetrahydrocannabinol. Studies using solid-state2H-and 13C-NMRwBB,*($ Biochimica et Biophysica Acta986141145Alexandros MakriyannisAlireza Banijamali, Harold C. Jarrell and De-Ping YangMEMBRANEThe orientation of (-)-delta-9-tetrahydrocannabinol in DPPC bilayers as determined from solid-stat H-NMRyCC-*'$ 293305Alexandros MakriyannisDe-Ping YangMEMBRANESolid State Nuclear Magnetic Resonance Spectroscopy in the Study of Drug: Membrane Interactions, Potential Applications with Antiarrhythmic AgentsMolecular and Cellular Mechanisms of Antiarrythmic AgentsHondeghem, LucFutura Publishing Company, Inc.Mount Kisco, NY?07/##  yPharmacology and Experimental Therapeutics25210751082Cecilia J. HillardJody J. Pounds, David R. Boyer and Alan S. BloomMEMBRANEStudies of the Role of Membrane Lipid Order in the Effects of Delta-9-Tetrahydrocannbinol on Adenylate Cyclase Activation Heart.~NN<841 241268David W. ChesterLeo G. HerbetteMEMBRANEMembrane Pathway for Drug Binding to Protein ReceptorsMolecular and Cellular Mechanisms of Antiarrhythmic AgentsLuc Hondeghem, M.D.Futura Publishing Company, Inc.Mount Kisco, NY 1989ַj4,  y> ? m&1Science275381383Rene OnrustPaul Herzmark, Patty Chi, Pablo D. Garcia, Olivier Lichtarge, Chris Kingsley, Henry R. BourneCOUPLINGReceptor and betagama Binding Sites in the alpha Subunit of the Retinal G. Protein Transducin"" Molecular Pharmacology42838845Christian C. FelderJeffrey S. Veluz, Holly L. Williams, Eileen M. Briley and Lisa A. MatsudaCB RECEPTORCannabinoid Agonists Stimulate Both Receptor- and Non-Receptor-Mediated Signal Transduction Pathways in Cells Transfected with and Expressing Cannabinoid Receptor Clones5555588%" Recl.Trav.Chim.Pays-Bas113167175L.A. MeijerF.A.M. Leermakers and J. LyklemaMEMBRANEHead-group conformations in lipid bilayer membranesZR22'$! 6289Philip YeagleMEMBRANELipid Properties in MembranesThe Membranes of CellsHarcourt Brace JovanovichOrlando, San Diego, New York, Austin, Boston, London, Sydney, Tokyo and TorontolSS=   ynLife Sciences4222312239Cornelis J. Van der SchyfThomas Mavromoustakos and Alexandros MakriyannisMEMBRANEThe Conformation of (-) 8alpha and (-) 8beta-Hydroxy-delta9-Tetrahydrocannabinols and their interactions with model membranesog77 Biophys.Biophysical Society59445455H.L. ScottMEMBRANELipid-cholesterol interactionsZZZZZ<444*'$" Pharm.Pharmacol31224230Sheldon H. RothPeter J. WilliamsMEMBRANEThe non-specific membrane binding properties of delta-9-tetrahydrocannabinol and the effects of various solubilizersF>-- Biophysical68164170Alan J. RobinsonW. Graham Richards, Pamela J. Thomas and Michael M. HannMEMBRANEBehavior of Cholesteros and Its Effect on Head Group and Chain Conformations in Lipid Bilayers: A Molecular Dynamics Studyjb** L>PdBiophysical68A21Wayne L. HubbellZorheh T. Farahbakhsh, Kevin D. Ridge, Ke Yang, Dave Farrens, John Resek and H. Govind KhoranaGPCR MODELSExploring Rhodopsin Structure and Dynamics with Site-Directed Spin Labelingې'' oMolecular Pharmacology50351358Susan M. WadeMary K. Scribner, Hiroko Mori Dalman, Joan M. Taylor and Richard R. NeubigGPCR COUPLINGStructural Requirements for G Activation by Receptor-Derived Peptides: Activation and Modulation Domains of the alpha2 Adrenergic Receptor i3c Region|22%" Molecular Pharmacology50140148Norman H. LeeNeil S. M. Geoghagen, Emily Cheng, Robin T. Cline and Claire M. FraserAlanine Scanning Mutagenesis of Conserved Argine/Lysine-Arginene/Lysine-X-X-Arginene/Lysine G Protein-Activating Motifs on m1 Muscarinic Acetylcholine Receptorsxx22%" Molecular Pharmacology516168Laurent AudolyRichard M. BreyerMUTATIONSubstitution of Charged Amino Acid Residues in Transmembrane Regions 6 and 7 Affect Ligand Binding and Signal Transduction of the Prostaglandin EP3 ReceptorJB11#! Molecular Pharmacology518796Dana E. SelleyLaura J. Sim, Ruoyo Xiao, Qixu Liu, and Steven R. ChildersCOUPLINGmu-Opioid Receptor-Stimulated Guanosine-5'-O-(gama-thio)-triphosphate Binding in Rat Thalamus and Cultured Cell Lines: Signal Transduction Mechanisms Underlying Agonist Efficacy%%%%%sk11#! Molecular Pharmacology51161169Vsevolod V. GurevichJeffrey L. BenovicCOUPLINGMechanism of Phosphorylation-Recognition by Visual Arrestin and the Transition of Arrestin into a High Affinity Binding StateSK99%" Proc. Natl. Acad. Sci.9339843989S.D. SkaperA. Buriani, R. Dal Toso, L. Petrelli, S. Romanello, L. Facci, and A. LeonCB RECEPTORThe ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons44444{22'# >;&2Biological Chemistry2711467214675Niva AlmaulaBarbara J. Ebersoles, Daqun Zhang, Harel Weinstein and Stuart C. SealfonMUTATION/GPCR MUTATIONMapping the Binding Site Pocket of the Serotonin 5-Hydroxytryptamine 2-A Receptor|44(# Annu Rev. Pharmacol. Toxicol35607634Allyn C. HowlettCB RECEPTORPharmacology of Cannabinoid ReceptorskkkkkF;;;+(%# A.K. DuttaW. Ryan, B.F. Thomas, M. Singer, D.R. Compton, B.R. Martin and R.K. RazdanAAISynthesis, Pharmacology and Molecular Modeling of Novel 4-Alkyloxy Indole Derivatives Related to Cannabimimetic Aminoalkyl Indoles (AAIs)^[ aRoger G. PertweeSusanthi R. Fermando, Graeme Griffin, William Ryan, Raj K. Razdan, David R. Compton and Billy MartinSARAgonist-antagonist characterization of 6'-cyanohex-2'-yne-Delta-8-tetrahydrocannabinol in two isolated tissue preparations~{ aJPET27311721181Irma B. AdamsWilliam Ryan, Michatil Singer, Brian F. Thomas, David R. Compton, Raj K. Razdan and Billy MartinANANDAMIDE CB RECEPTOREvaluation of Cannabinoid Receptor Binding and in Vivo Activities for Anandamide Analogs##  Molecular Pharmacology4910211032Gregory H. HockermanMark E. Girvin, Craig C. Malbon and Arnold E. RuohoLABELLINGAntagonist Conformations with the Beta-2-Adrenergic Receptor Ligand Binding Pocketwn;;'# Biopolymer30287298R. SankararamakrishnanSaraswathi VishveshwaraGPCR MODELSConformational Studies on Peptides with Proline in the Right-Handed alpha-Helical RegionQF// Computer Aided Molecular Design3223T.J. MitchellM.S. Tute and G.A. WebbGPCRA molecular modelling study of the interaction of noradrenaline with the Beta2-adrenergic receptorRN77*''& wB>evBZ\Medicinal Chemistry3622192227Mark FroimowitzViviam CodyMODELLING PHARMACOPHORE DEVELOPMENTBiologically Active Conformers of Phenothiazines and Thioxanthenes. Further Evidence for a Ligand Model of Dopamine D2 Receptor Antagonistsa>33$  Drug Design and Discovery134962Martha M. TeeterCurtiss J. DurandPHARMACOPHORE DEVELOPMENTDopamined Receptor Model Explains Binding Affinity of Neuroleptics: Piquindone And Its Structure Activity Relationships`G66&$"  MOl Model13645Mark FroimowitzEmile M. Bellott, Jr.MODELLINGStructural Factors that Distinguish Dopamine D1 and D2 AgonistsB9$$ Med. Chem2915701573M. FroimowitzJ.L. Neumeyer, R.J. BaldessariniMODELLINGA Stereochemical Explanation of the Dopamine Agonist and Antagonist Activity of Stereoisomeric PairPG'' Drug Design and Discovery137381Mark FroimowitzYuanwei Deng, James N. Jacob, Naiyin Li, and Vivian CodyMODELLINGDopaminergic (4aR, 10bS)-CIS- and (4aS, 10bS)- Trans-Octahydrobenzo[f]Quinolines Have Similar Pharmacophoresvm55&$"  Pharmaceutical Sciences76557564Mark FroimowitzRoss J. BaldessariniPHARMACOPHORE DEVELOPMENT MODELLINGA Stereochemical and Conformational Model of Dopaminergic Agonists and Antagonist Activity: Futher EvaluationlI55&#  Biological Chemistry2712644526448Gezhi WengJingrong Li, Jane Dingus, John D. Hildebrandt, Harel Weinstein and Ravi IyengarCOUPLINGG Beta Subunit Interacts with a Peptide Encoding Region 956-982 of Adenylyl Cyclase 2މ22(# Molecular Pharmacology503442Niva AlmaulaBarbara J. Ebersole, Juan A. Ballesteros, Harel Weinstein and Stuart C. SealfonMUTATION/GPCR MUTATIONContribution of a Helix 5 Locus to Selectivity of Hallucinogenic and Nonhallucinogenic Ligands for the Human 5- Hydroxytryptamine 2-A and 5-Hydroxytryptamine2-C Receptors: Direct and Indirect Effects on Ligand Affinity Mediated by the Same Locus~//#! >)tBiochemistry2660306038Alan R. FershtRobin J. Leatherbarrow, and Tim N.C. WellsGPR INTERACTIONSStructure-Activity Relationships in Engineered Proteins: Analysis of Use of Binding Energy by Linear Free Energy RelationshipseU++ Med Chem Res3344356Timothy K. GallaherIan S. Haworth and Jean C. ShihGPCR MODELSDetermining the Ligand Binding Site of the 5-HT2 Receptor Using Molecular Mechanics and Molecular DynamicsWL-- Ann.Rev. Biophys. Biophys. Chem15321353D.M. EngelmanT.A. Steitz, and A. GoldmanRECEPTORIdentifying Nonpolar Transbilayer Helices in Amino Acid Sequences of Membrane Proteins^V;;.+(& Molecular Structure (Theochem)314265275F. FanelliM.C. Menziani, M. Cocchi, A. Leonardi, P.G. De BenedettiGPCR MODELThe heuristic-direct approach to theoretical quantitative structure-activity relationship analysis of alpha-adrenoceptor ligandszp88.+(% Quantum Chemistry:Biology Symposium19197215D. TimmsA.J. Wilkinson, D.R. Kelly, K.J. Broadley and R. H. DaviesGPCR MODELInteractions of Tyr 377 in a Ligand-Activation Model of Signal Transmission through beta1-Adrenoceptor alpha-Helices~t::2/,* Biological Chemistry2693029930306Laura B. KosellCurtis A. Machidas, Rachael L. Neve, and Kim A. NeveMUTATIONChimeric D1/D2 Dopamine Receptorssk77(# Neurochemistry59627635Barbara A. CoxRobert A. Henningsen, Athena Spanoyannis, Rachael L. Neve, and Kim A. NeveMUTATIONContributions of Conserved Serine Residues to the Interactions of Ligands with Dopamine D2 Receptors}u++ Medicinal Chemistry3417071714Mark FroimowitzSten RamsbyMODELLING PHARMACOPHORE DEVELOPMENTConformational Properties of Semirigid Antipsychotic Drugs: The Pharmacophore for Dopamine D-2 Antagonist Activitya>33$  > "Bb X/Clin Pharmacol21271S282SM.R. JohnsonL.S. Melvin, T.H. Althuis, J.S. Bindra, C.A. Harbert, G.M. Milne and A. WeissmanSARSelective and Potent Analgetics Derived Cannabinoids~{++ Neurochem63S79Nomi EshharSarina Striem, Varda Nadler and Anat BiegonSARHU-211, A Non-Psychotropic Cannabinoid as a Novel Neuroprotectant AgentNK  oBiochem. Pharmacolin pressSumner H. BursteinJohn K. Young and George E. WrightSARRelationships Between Eicosanoids and Cannabinoids Are Eicosanoid Cannabimimetic AgentsXU33!!! gNeurochem61S65A. Bar JosephY. Berckovich, V. Greenberger, and A. BiegonSARNeuroprotective Activity of HU211, A non-psychotropic synthetic cannabinoidQN"" oAm.Chem.Soc.10679597969H.A. ScheragaM. Oka, G.T. MontelioneGPR INTERACTIONSChain-Folding Initiation Structures in Ribonuclease A: Conformational Free Energy Calculations on Ac-Asn-Pro-Tyr-NHMe, Ac-Tyr-Pro-Asn-NHMe, and Related PeptiedesRB++ J. Am. Che. Soc.10679467958H.A. ScheragaG.T. Montelione, E. Arnold, Y.C. Meinwald, E.R. Stimson, J.B. Denton, S.-G. Huang, J. ClardyGPR INTERACTIONSChain-Folding Initiation Structures in Ribonuclease A: Conformational Analysis of trans-Ac-Asn-Pro-Tyr-NHMe and trans-Ac-Tyr-Pro-Asn-NHMe in Water and in the Solid StateEEEEE//" J. Mol. Biol.239315331John B. O. MitchellC. Lilian Nandi, Ian K. McDonald, Janet M. ThorntonGPR INTERACTIONSAmino/Aromatiac Interactions in Proteins: Is the Evidence Stacked Against Hydrogen Bonding?sc00 Science235574576Peter A. KollmanPaul A. Bash, U. Chandra Singh, Frank K. Brown, Robert LangridgeGPR INTERACTIONSCalculation of the Relative Change in Binding Free Energy of a Protein-Inhibitor Complexwg'' Phil. Trans. R. Soc. Lond.317305320A.R. FershtR.J. Leatherbarrow and T.N.C. WellsGPR INTERACTIONSStructure and activity of the tyrosyl-tRNA synthetase: the hydrogen bond in catalysis and specificityhX55*'$! C>i%[ Med.Chem.3310371043Raphael MechoulamAviva Breuer, Tobjorn U.C. Jarbe, Arto J. Hiltunen, and Robert GlaserSARCannabimimetic Activity of Novel Enantiomeric, Benzofuran Cannabinoidssp++  777793R. MechoulamN. Lander, M. Srebnik, I.Zamir, A. Breuer, B. Shalita, S. DiksteinSARRecent Advances in the Use of Cannabinoids as Therapeutic AgentsThe Cannabinoids: Chemical, Pharmacologic, and Therapeutic AspectsStig AgurellAcademic Press, Inc.Orlando, San Diego, San Francisco New York, London, Toronto, Montreal Syndney Tokyo Sao Paulo^^[  y Tetrahedron5026712680Marcus A. TiusAlexandros Makriyannis, Xiang Long Zou, and V. AbadjiSARConformationally Restricted Hybrids of CP-55,940 and HHC: Stereoselective Synthesis and Activityb_**  545561Robert D. FordRobert L. Balster, William L. Dewey, John A. Rosecrans, Louis S. HarrisSARThe Discriminative Stimulus Properties of Delta 9 Tetrahydrocannabinol: Generalization to Some Metabolites and CongnersThe Cannabinoids: Chemical, Pharmacologic, and Therapeutic AspectsStig AgurellAcademic PressOrlando, San Diego, San Francisco, New York, London, Toronto, Montreal Sydney Tokyo San Paulo:, eb  yProc.Natl.Acad.Sci.8695849587Jeffery J. FeigenbaumFelix Bergmann, Saul A. Richmond, Raphael Mechoulam, Varda Nadler, Yoel Kloog and Mordechai SokolovskySARNonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker99$  Med. Chem.3530763079Avgui CharalambousGuo Yan, Devin B. Houston, Allyn C. Howlett, David R. Compton, Billy R. Martin, Alexandros MakriyannisSAR5'-Azido-delta8-THC: A Novel Photoaffinity Label for the Cannabinoid Receptor䖓-- Neuroscience Letters174101104Hiroshi KnoshitaTakaaki Hasegawa, Tustomu Kameyama, Ikuo Yamamoto, Toshitaka NabeshimaSARCompetitive NMDA antagonists enhance the catalepsy induced by delta9-tetrahydrocannabinol in mice}z44$! >  :*_/Br. J. Pharmacol10982PS.J. PatersonR.G. PertweeSARCharacterization of the Cannabinoid Binding Site in the Guinea-Pig{{{{{96** oBritish J. Pharmacol10983PA.P. WickensS.H. Burstein, and R.G. PertweeSARThe Effect of Delata-9-Tetrahydrocannabinol on the Degree of Catalepsy Induced in Rats by Intrapallidal Injections of Muscimol, Baclofen or Prostaglandine E2OL--!! oBr. J. Pharmacol109105PG. GriffinR.G. PertweeSARVasa Deferentia Obtained from Mice Pretreated With Delta-9-Tetrahydrocannabinol (THC) Show Tolerance to Delta-9-THC, WIN 55212-2 and CP 55,94074(( o133Raphael MechoulamDevane and GlaserSARCannabinoid Geometry and Biological ActivityMarijuana/CannabinoidsLaura Murphy and Andrzej BartkeCRC PressBoca Raton, Ann Arbor, London and Tokyoq[/,  yMed. Chem.3310371043Raphael MechoulamAviva Breuer, Tobjorn U.C. Jarbe, Arto J. Hiltunen, and Robert GlaserSARCannabimimetic Activity of Novel Enantiomeric, Benzofuran Cannabinoidstq,, European J. of Pharmacology156361366Torbjorn U.C. JarbeArto J. Hiltunen, Raphael Mechoulam, Morris Srebnik and Aviva BreuerSARSeparation of the discriminative stimulus effects of stereoisomers of delta-2 and delta-3tetrahydrocannabinols in pigeons>>+(%" Psychoparmacologia40116Torbjorn U.C. JarbeBengt G. HenrikssonSARDiscriminative Response Control Produce with Hashish, Tetrahydrocannabinols (Delta-8-THC and Delta-9-THC), and Other DrugsGD11 Lawrence S. MelvinGeorge M. Milne, M. Ross Johnson, Gerald H. Wilken and Allyn C. HowlettSARStructure-Activity Relationships Defining the ACD-Tricyclic Cannabinoids: Cannabinold Receptor Binding and Analgesic Activityc` a Pharmacology Biochemistry and Behavior47113119Torbjorn U.C. JarbeRaphael Mechoulam and Jamal ZahalkaSARDiscriminative Stimulus-and Open-Field Effect of the Enantiomers of 11-Hydroxy-Delta-8-Tetrahydrocannabinol in Pigeons and GerbilsnkHH52/- > @|$"vT Zoological Studies33128Ren-Jye HoGPCR GENERAL A-NTransmembrane Signaling and Animal Evolutioneeeee9((( Biophys. J. Biophysical Society499194Leo G. HerbetteDavid W. Chester and David G. RhodesGPCR GENERAL A-NStructural Analysis of Drug Molecules in Biological Membranesp_;;,*(& TIPS106469Paul R. HartigGPCR GENERAL A-NMolecular biology of 5-HT receptorsSSSSS0  Proc.Natl. Acad.Sci9128002804Susanne M. MumbyChristiane Kleuss, and Alfred G. GilmanGPCR GENERAL A-NReceptor regulation of G-protein palmitoylationl[44$  Science25013771382Robert L. DoritLloyd Schoenbach, Walter GilbertGPCR GENERAL A-NHow Big Is the Universe of ExonsyyyyyYH(( Science253677679Russell DoolittleGPCR GENERAL A-NCounting and Discounting the Universe of Exonsggggg9((( Cell73631641Bruce R. ConklinHenry R. BourneGPCR GENERAL A-NStructural Elements of Ga Subunits That Interact with Gbetagama, Receptors, and EffectorsC2##  TIPS11485492Jean-Pierre ChangeuxGPCR GENERAL A-NThe nicotinic acetylcholine receptor: an allosteric protein prototype of ligand-gated ion channels8'''  Pharmacology and Experimental Therapeutics27310081014Alain BotellaMichel Delvaux, Jean Fioramonti, Jacques Frexinos and Lionel BuenoGPCR GENERAL A-NReceptor Subtypes Involved in Dual Effects Induced by Prostaglandin E2 in Circular Smooth Muscle from Dog Colon II<841 Biochimica et Biophysica Acta1071393406Jay L. BanksGPCR GENERAL A-NStructure and ligand binding in membrane-bound proteins and immunoglobulinsK:::.+($ 14th ISN Meeting, Montpellier, FranceS206Fonseca, M. CeberiaJ.A. Ramos, M.L. Hernandez, J. Romero and J.J. Fernandez RuizSARBrain Cannabinoid Receptors and Sex SteroidsCC00,, k>4'Biological Chemistry26927902795Robert J. LefkowitzLarry S. Barak, Mario Tiberi, Neil J. Freedman, Madan M. Kwatra and Marc G. CaronGPCR GENERAL A-NA Highly Conserved Tyrosine Residue in G Protein-coupled Receptors Is Required for Agonist-mediate beta2-Adrenergic Receptor Sequestration%%%%%99&" &Biological Chemistry26349934996Robert J. LefkowitzMarck G. CaronGPCR GENERAL A-NAdrenergic Receptor Models For the Study of Receptors Coupled to Guanine Nucleotide Regulatory ProteinsXG99&" %Biological Chemistry2691577615785Brian E. HawesLouis M. Luttrell, Sabrina T. Exum, and Robert J. LefkowitzGPCR GENERAL A-NInhibition of G Protein-coupled Receptor Signaling by Expression of Cytoplasmic Domains of the Receptorq66(# $Neurochem63S2D. LancetN. Ben-Arie, U. Gat, S. Horn-Saban, M. Natochin, E. Nekrasova, M. Khen, N. Walker, M. North and H. LehrachGPCR GENERAL A-NMapping The Superfamily of G-Protein Coupled Receptors in Olfaction.ܘ o#Cellular and Molecular Neurobilogy5523Judy A. KingRobert P. MillarGPCR GENERAL A-NEvolutionary Aspects of Gonadotropin-Releasing Hormone and its ReceptorZI99-+*) "Biological Chemistry2691642516433Jeffrey R. KeeferMatthew E. Kennedy and Lee E. LimbirdGPCR GENERAL A-NUnique Structural Features Important for Stabilization Versus Polarization of the a2a-Adrenergic Receptor on the Basolateral Membrane of Madin-Darby Canine Kidney Cellso^99(# !Am. Chem. Soc.11238963904Mir Wais HosseiniA. John Blacker, and Jean-Marie LehnGPCR GENERAL A-NMultiple Molecular Recognition and Catalysis. A Multifunctional Anion Receptor Bearing an Anion Binding Site, an Intercalating Group, and a Catalytic Site for Nucleotide Binding and Hydrolysis'''''fU11  > O`nw81Analytical Biochemistry107220239Peter J. MunsonDavid RodbrardGPCR GENERAL A-NLigand: A Versatile Computerized Approach for Characterization of Ligand-Binding SystemsUD66'$! 0European J. of Pharmacology179435439Timothy V. MurphyHenryk MajewskiGPCR GENERAL A-NPertussis toxin differentiates between alpha1-and alpha2-adrenoceptor-mediated inhibition of noradrenaline release from rat kidney cortex\K<<+(%" /Nature333129134Eva J. NeerDavid E. ClaphamGPCR GENERAL A-NRoles of G protein subunits in transmembrane signallingyyyyyB1!!  .Protein Science3314Eva J. NeerGPCR GENERAL A-NG proteins: Critical control points for transmembrane signalsttttt6%%% -FASEB8939946Richard R. NeubigGPCR GENERAL A-NMembrane organization inG-protein mechanismsaaaaa5$$$  ,Med. Chem.40659667Tzviel SheskinLumir Hanus, Joram Slager, Zvi Vogel, and Raphael MechoulamANANDAMIDE (AAE) /CB RECEPTORStructural Requirements for Binding of Anandamide-Type Compounds to the Brain Cannabinoid Receptorb'' +Ciba Foundation Symposium1797687Michael R. LernerMarc N. Potenza, Gerard F. Graminski, Tim McClintock, Channa K. Jayawickreme and Suresh KarneGPCR GENERAL A-NA new tool for investigating G protein-coupled receptorsަ88'%#  *GPCR GENERAL A-NExitatory Amino Acids in Health and DiseaseCCCCC !)19J. W. ReganM.G. Caron and R.J. LefkowitzGPCR GENERAL A-NStructural Determinant of Ligand Binding to Alpha- and Beta-AdrenoceptorsTransmembrane Signalling, Intracellular Messenger and Implication for Drug DevelopmentS.R. NahorskiJohn Wiley & Sons LtdB1  y?(Proc.Natl.Acad.Sci.8488798882R. J. LefkowitzJ.L. Benovic, H. Kuhn, I Weyand, J. Codina and M.G. CaronGPCR GENERAL A-NFunctional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: Potential role of an analog of the retinal protein arrestin (48-kDa protein)66666}l33$  >=pb59Nature Genetics299102Ans M. W. van den OuwelandJos C.F.M. Dreesen, Marian Verdijk, Nine V.A.M. Knoers, Leo A.H. Monnens, Mariano Rocchi and Bernard A. van OostMUTATION A-PMutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus66 8Biological Chemistry2701273012736Fan MengMary T. Hoversten, Robert C. Thompson, Larry Taylor, Stanley J. Watson and Huda AkilMUTATION A-PA Chimeric Study of the Molecular Basis of Affinity and Selectivity of the k and the delta Opioid Receptors00(# 7Biochem295629633Shuizing LIJinmin Zhu, Chogguang Chen, Yung-Wu Chen, J. Kim Deriel, Barrie Ashby and Lee-Yuan Liu-ChenCLONESMolecular cloning and expression of rat k opioid receptor}"" 6Life Sciences56201207Lee Yuan Liu ChenJinmin Zhu, Chongguang Chen, Ji-Chun Xue, Satya Kunapuli, J. Kim DeRielCLONESCloning of a Human k Opioid Receptor from the brainzt-- 5Biological Chemistry2702277222776Shengwen ZhangLei YuCLONESIdentification of Dynorphins as Endogenous Ligands for an Opioid Receptor-like Orphan ReceptorB<66(# 4Molecular Pharmacology44749756Lee-Yuan Liu-ChenChongguang Chen, and Catherine A. PhillipsGPCR GENERAL A-NBeta-[3H]Funaltrexamine-Labeled mu-Opioid Receptors:Species Variations in Molecular Mass and Glycosylation by Complex-Type, N-Linked Oligosaccharidesq`66%" 3Pure & Appl. Chem.666569John L. MarkleyAndrew P. Hinck, Stewart N. Loh, Kenneth Prehoda, Dagmar Truckses, William F. Walkenhorst and Jinfeng WangGPCR GENERAL A-NCase study of protein structure, stability, and function: NMR investigations of the proline residues in staphylococcal nuclease))))).. 2Biophysical6815401550Dmitry MikhailovVladimir A. Daragan and Kevin H. MayoGPCR GENERAL A-N13C Multiplet Nuclear Magnetic Resonance Relaxation-Derived Ring Puckering and Backbone Dynamics in Proline-Containing Glycine-Based PeptidesbQ,, H>/{bAArchives of Biochemistry and Biophysics322256264Mitsuru HaniuJane Talvenheimo, John Le, Viswanatham Katta, Andrew Welcher and Michael F. RohdeMUTATION A-PExtracellular Domain of Neurotrophin Receptor trkB: Disulfide Structure, N-Glycosylation Sites, and Ligand BindingDD741. @Biochemistry341341213422Bomie HanArmen H. Tashjian, Jr.MUTATION A-PIdentification of Asn289 as a Ligand Binding Site in the Rat Thyrotropin-Releasing Hormone (TRH) Receptor As Determined by Complementary Modifications in the Ligand and Receptor: A New Model for TRH BindingK>(( ?Science250123125H. Gobind KhoranaRoland R. Franke, Bernd Konig, Thomas P. Sakmar, and Klaus P. HofmannMUTATION A-PRhodopsin Mutants That Bind But Fail to Activate Transducinzm(( >Molecular Pharmacology49216223Christopher EvansKatia Befort, Lina Tabbara, Suzanne Bausch, Charles Chavkin and Brigitte KiefferMUTATION A-PThe Conserved Aspartate Residue in the Third Putative Transmembrane Domain of the alpha-Opioid Receptor Is not the Anionic Counterpart for Cationic Opiate Binding but Is a Constituent of the Receptor Binding Siteggggg66%" =Biophysical Chemistry567987Godelieve L.J. De CaluwePetra H.M. Bovee-Geurts, Parshuram Rath, Kenneth J. Rothschild, and Willem J. de GripMUTATION A-PEffect of carboxyl mutations on functional properties of bovine rhodopsin圏::"  <Society for Neuroscience Abstracts19726.8E. S. BursteinD.H. Eubanks, H.B. Jorgensen, and M.R. BrannMUTATION A-PStructure/Function of Muscarinic Receptor/G-Protein Couplinwj>>00+) o;Comp.Biochem. Physiol.100A775787Marianna PertsevaMUTATION A-PThe Evolution of Hormonal Signalling SystemsqqqqqE888'$! :Life Sciences56915922Jurgen WessNathalie Blin, Ernst Mutschler and Klaus BlumlMUTATION A-PMuscarinic Acetylcholine Receptors: Structural Basis of Ligand Binding and G Protein CouplingbU'' &>?V@IMolecular Pharmacology41695698Brian K. KobilkaXiao-Ming Guan, Stephen J. PeroutkaMUTATION A-PIdentification of a Single Amino Acid Residue Responsible for the Binding of a Class of Beta-Adrenergic Receptor Antagonists to 5-Hydroxytryptamine1A-ReceptorseX55%" HBiological Chemistry2672199121994Brian K. KobilkaSankuratri Suryanarayana, Mark von ZastrowMUTATION A-PIdentification of Intramolecuar Interactions in Adrenergic Receptorsob88(# GBiological Chemistry2661548815492Brian K. KobilkaSankuratri Suryanarayana, David A. Daunt Mark Von ZastrowMUTATION A-PA Point Mutation in the Seventh Hydrophobic Domain of the alpha2 Adrenergic Receptor Increases Its Affinity for a Family of Beta Receptor Antagonists~q88(# FBiological Chemistry26374397442H.G. KhoranaMUTATION A-PBacteriorhodopsin, a Membrane Protein That Uses Light to Translocate Protons?222&" EBiological Chemistry2671778017786Charles W. HutchinsNancy J. Pollock, Arlene M. Manelli, Michael E. Steffey, Robert G. MacKenzie and Donald E. FrailMUTATION A-PSerine Mutations in Transmembrane V of the Dopamine D1 Receptor Affect Ligand Interactions and Receptor Activation;;(# DMedicinal Chemistry3312751281Morley D. 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BuckGPCR GENERAL O-ZMolecular Biology of Adrenergic and Muscarinic Cholinergic ReceptorsƂr88)%! \FEBS3594549Catherine Venien-BryanAnthony Davies, Keith Langmack, Jenny Baverstock, Anthony Watts, Derek Marsh, Helen SaibilGPCR GENERAL O-ZEffect of the C-terminal proline repeats on ordered packing of squid rhodopsin and its mobility in membranes((  >> B6\mPharmacologist33D7S.E. LukasM. Fortin, E. Kouri and J.H. MendelsonCB-RECEPTOR L-ZBehavioral and Physiological Effects of Marihuana and Cocaine Alone, and in Combination, in Human Male VolunteersXI## olA381Y.LaiK. Mackie, R. MitchellCB-RECEPTOR L-ZCannabinoids Activate an Inwardly Rectifying Potassium Conductance in AtT20 Cells Expressing Rat Cannabinoid Receptor5&  ikA381Sanjay N. ThoratHemendra BhargavaCB-RECEPTOR L-ZEffect of Inhibition of NMDA Receptor and Nitric Oxide Synthase on Analgesia, Hypotherma and Tolerance Induced by Delta -9-Tetrahydrocannabinol in the Mouse<-  ijNeuroimmunology55107115Herbert SchwarzFrancisco J. 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ZimmermanCB RECEPTOR A-KEvidence for a Cannabinoid Receptor in Spermvf  grL107Gautam ChaudhuriEmmanuel S. OnaiviCB RECEPTOR A-KCharacterization of the Trascriptional Initiation Sites of the Brain-Type and the Peripheral-Type Human Cannabinoid Receptor=-  iqNature346508Solomon H. SnyderCB-RECEPTOR L-ZPlanning for serendipityKKKKK3$$$  opNucleic Acids Research194798L. CaenazzoM.R. Hoehe, W. T. Hsieh, W.H. Berretini, T.I. Bonner and E.S. GershonCB-RECEPTOR L-ZHindlll identified a two allele DNA polymorphis of the human cannabinoid receptor agne (CNR)ނs..## ooNucleic Acids Research194798W. XuL. Liu, D. M. Black and B.A. J. PonderCB-RECEPTOR L-ZA Bglll polymorphism in the human NF1 gene]N((## onPharmacologist33D8Aron H. LichtmanBilly R. MartinCB-RECEPTOR L-ZBehavioral Effects of Centrally Administered Cannabinoids to Specific Brain Regions In Rats.G8)) o> \Naunyn-Schmiedeberg's Arch Pharmacol354791Eberhard SchlickerJorg Timm Manfred GutherCB RECEPTORCannabinoid receptor-mediated inhibilion of dopamine release in the retinaf[CC1.++ {~Biochemical Pharmacology53207214Mary E. AboodKara E. Ditto, Melissa A. Noel, Vincent M. Showalter and Qing TaoCB RECEPTORIsolation and Expression of a Mouse CB1 Cannabinoid Receptor Gene (Comparison of Binding Properties with those of Native CB1 Receptors in Mouse Brain and N18TG2 Neuroblastoma Cells44444u44'$! }Biochemical Pharmacology53255260Dale G. DeutschRomelda Omeir, Gladys Arreaza, David Salehami, Glenn D. Prestwich, Zheng Huang and Allyn HowlettAAEMethyl Arachidonyl Fluorophosphonate: A Potent Irreversible Inhibitor of Anandamide Amidase66'$! |Neuroscience77299318M. GJ. ASSM. Dragunow and R.L. M. 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SingerAK Dutta, DR Compton, BR Martin, RK RazdanCB SARSynthesis and pharmacology of (R)-and (S)-4'-hydroxy-delta-9-tetrahydrocannabinolsWQ'' Forensic Sciences42323325Nicholas J. GiardinoCB ANALYTICALAn Indoor Air Quality-Pharmacokinetic Simulation of Passive Inhalation of Marijuana Smoke and the Resultant Buildup of 11-Nor-Delta-9-Tetrahydrocannabinol-9-Carboxylic Acid in UrineA444  Brit. J. Pharmacol119290L.J. StewardF.G. Boess, J.A. Steele, B.P. Phipps, D. Liu and B. L. MartinMUTATIONThe Importance of the Amino Acid Phenylalanine 107 For Function and Ligand Recognition at the 5-HT3 Receptorph++ oBr. J. Pharmacol119316PR.G. PertweeF. Lopez-Redondo, and G.M. LeesSAREffects of the Cannabinoid Receptor Agonist WIN 55,212-2, On Fast Synaptic Transmission in Myenteric Plexus Neurones of the Guinea-Pig IleumLI** oNeuroscience Letters221157160U. HerbergE. Eliav, B.J. Bennett, Irwin J. KopinAAIThe analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in rat model of neuropathic painWT..$! Brit. J. Pharmacol119312PR.G. PertweeA. A. CouttsSAREffect of Cannabinoid Agonists and SR141716A on Acetylcholine Release from the Myenteric Plexus of the Guinea-Pig Small Intestine;8,,  oEuropean Journal of Pharmacology321R1R2Yoshiaki HosahataRaymond M. Quock, Keiko Hosahata, Alexandros Makriyannis, Paul Consroe, William R. Roeske, Henry I. YamamuraCB RECEPTOR/SAR AntagonistAM630 antagonism of cannabinoid-stimulated [35S]GTPgamaS binding in the mouse brainū??.,*' Biochemical Pharmacology53433435Alfred E. A. ThumserJoanne Voysey and David C. WiltonAAEA Fluorescence Displacement Assay for the Measurement of Arachidonoyl Ethanolamide (Anandamide) and Oleoy Amide (Octadecenoamide) Hydrolysis_\;;'$! >ILancet3481436Rachelle H.B. FishmanCB SARCannabinoid derivative protects neuronsVVVVV/)))  oBiochemical Pharmacology533541Mary F. RuhJulia A. Taylor, Allyn C. Howlett, and Wade V. WelshonsCB PHARMACOLOGYFailure of Cannabinoid Compounds to Stimulat Estrogen Receptorsvg00%#! Neuroscience Letters220101104Robert A. HirstSarah L. Almond, David G. LambertCB RECEPTORCharacterization of the rat cerebella CB1 receptor using SR141716A, a central cannabinoid receptor antagonist_T33$! Psychiat. Prax23298299Hans-Jorg Frank Assion, BonnFrank Heinemann, MoersCB PHARMACOLOGYPsychische Storungen nach einmaliger Einnahme von 3,4-methylenedioxyethamphetamine (MDE,,,Eve" und Tetrahydrocannabinol (Cannabis)^O99 Molecular Brain Research44191197T. RubinoG. Patrini, M. Parenti, P. Massi, D. ParolaroCB RECEPTORChronic treatment with a synthetic cannabinoid CP-55,940 alters G-protein expression in the rat central nervous systemh]00'$! Neuropharmacology3517931804Jenny L. WileyDavid R. Compton, Patrick M. Gordon, Craig Siegel, Michael Singer, Aloke Dutta, Aron H. Lichtman, Robert L. Balster, Raj K. Razdan and Billy R. MartinSAREvaluation of Agonist-antagonist Properties of Nitrogen Mustard and Cyano Derivatives of Delta-8-Tetrahydrocannabinol>>>>>00" Neuropharmacopy35983991J.S. PolingM.A. Rogawski, N. Salem Jr. and S. ViciniAAEAnandamide, an Endogenous Cannabinoid, Inhibits Shaker-related Voltage-gated K+ ChannelsUR)) Toxicology and Applied Pharmacology142278287Anthony R. SchatzMichael Lee, Robin B. Condie, James T. Pulaski, and Norbert E. KaminskiCB RECEPTORCannabinoid Receptors CB1 and CB2: A Characterization of Expression and Adenylate Cyclase Modulation within the Immune SystemDD30-* >/FEBS Letters3951721Catherine MollereauChristiane Moisand, Jean-Luc Butour, Marc Parmentier, and Jean-Claude MeunierMUTATIONReplacement of Gln by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioidsz-- FASEB11A205P.J. WinsauerP. Lambert and J. M. MoerschbaecherSR141716ASR141716A Antagonizes the Effects of Delta-9-THC on Complex Behavioral Processes in MonkeysKB  oNeuroscience1712261242Hugues CadasEmmanuelle di Tomaso, and Daniele PiomelliAEAOccurrence and Biosynthesis of Endogenous Cannabinoid Precursor, N-Arachidonyl Phosphatidylethanolamine, in Rat BrainVS)) Res Communicat in Alcohol and Substance of Abuse175769Toshiyuki KimuraIkuo Yamamoto, Tomoko Ohta, Hisatoshi Yoshida, Kazuhito Watanabe, Ing. Kang Ho, and Hidetoshi YoshimuaCB SARChanges in 5-HT Receptor Binding Induced by Tetrahydrocannabinol Metabolites in Bovine Cerebral CortexMM=;97 Experimental and Clinical Psychopharmacology57482Thomas H. KelleyRichard W. Foltin, Cleeve S. Emurian, and Marian W. FischmanCB PSYCHOLOGYAre Choice and Self-Administration of Marijuana Related to Delta-9-THC Content?HH8643 Prostaglandis, Leukotrienes and Essential Fatty Ac55207210D.L. BoringB.A. Berglun, A.C. HowlettAEACerebrodiene, arachidonyl-ethanolamide, and hybrid structures: pottential for interaction with brain cannabinoid receptorsifLLA>;9 Gen Pharmac.2711411143G.M. LewCB IMMUNETau Protein after Delta-9-tetrahydrocannabinol in a Human Neuroblastoma Cell Line.%%% Analytical Toxicology20573578Maria SzirmaiOlof Beck, Nikolaj Stephansson and Magnus M. HalldinCB METABOLISMA GC-MS Study of Three Major Acidic Metabolites of delta1-Tetrahydrocannabinolre11$! >iL Biochemical and Biophysical Research Comm229114120Michael D. RandallStephen P.H. Alexander, Terence Bennett, E. Andrew Boyd, Jeffrey R. Fry, Sheila M. Gardiner, Philip A. Kemp, Audrey I. McCulloch, and David A. KendallAEA CB RECEPTORAn Endogenous Cannabinoid as an Endothelium-Derived Vasorelaxant00000KK9630 Biochemical & Biophysical Research Comm229687692Helgi B. SchiothRuta Muceniece, Michael Szardenings, Petris Prusis and Jarl E. S. WikbergMUTATIONEvidence Indicating That the TM4, EL2, and TM5 of the Melanocorting 3 Receptor Do Not Participate in Ligand Binding GG741. Behavioral Pharmacology7276284P.E. MalletR.J. BeningerAEAThe endogenous cannabinoid receptor agonist anandamide impairs memory in rats@=00%" Life Sciences5919691979Thomas MavromoustakosDe-Ping Yang, and Alexandros MakriyannisCB SAR MEMBRANETopography and Thermotropic Properties of Cannabinoids in Brain Sphingomyelin Bilayersj[33 Molecular Neuroscience7291308Ana BonninRosario de Miguel, Javier G. Castro, Jose A. Ramos, and Javier J. Fernandez-RuizCB DEVELOPMENTEffects of Perinatal Exposure to Delta-9-Tetrahydrocannabinol on the Fetal and Early Postnatal Development of Tyrosine Hydroxylase-Containing Neurons in Rat Brain.....~..$! Tetrahedron5315571576John W. HuffmanJulia A. H. Lainton, W. Kenneth Banner, Sammy G. Duncan, Jr., Robert D. Jordan, Shu Yu, Dong Dai, Billy R. Martin, Jenny L. Wiley and David R. ComptonCB SARSide Chain Methyl Analogues of Delta-8THC++ Neuroscience Letters220101104Robert A. HirstSarah L. Almond, David G. LambertSR141716A CB RECEPTORCharcterisation of the rat cerebella CB1 receptor using SR141716A, a central cannabinoid receptor antagonistiT33$! >}Br. J. Pharmacol11931PA.K. CadoganE.A. Boyd, S.P.H. Alexander and D.A. KendallCB RECEPTORInfluence of Cannabinoids on Dopamine Release and cAMP Generation in the Rat Striatum`U)) oBrain Research733184192Timothy J. TersigniHoward C. RosenbergCB PHARMACOLOGYLocal pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABASD11 Nat. Prod.60168170Hiroyuki TanakaRyuji Takahashi, Satoshi Morimoto and Yukihiro ShoyamaCB SARA New Cannabinoid, Delta-6-Tetrahydrocannabinol 2'-O-Beta-D-Glucopyranoside, Biotransformed by Plant Tissued^(( Pharmacology & Experimental Therapeutics279608616George Pugh, Jr.Peter B. Smith, Daniel S. Dombrowski and Sandra P. WelchCB AnalgesiaThe Role of Endogenous Opioids in Enhancing the Antinociception Produced by the Combination of Delta-9-Tetrahydrocannabinol and Morphine in the Spinal Cord.(((((HH852/ FEBS Letters403263267Massimiliano BeltramoEmmanuelle di Tomaso, Daniele PiomelliAEAInhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-oneZW11 International J. of Quantum Chemistry61127135Micholas S. BodorMing-Ju HuangCB SARTheoretical study of the Stereoisomers of TetrahydrocannabinolsXREE41., Biochemical & Biophysical Research Comm2295864Takayuki SugiuraTomoko Dodaka, Sachiko Kondo, Takashi Tonegawa, Shinji Nakane, Seishi Kishimoto, Atsushi Yamashita and Keizo WakuAAE2-Arachidonoylglycerol, a Putative Endogenous Cannabinoid Receptor Ligand, Induces Rapid, Transient Elevation of Intracellular Free Ca2+ in Neuroblastoma X Glioma Hybrid NG108-15 CellsqqqqqEE531. \> :]vNeuroscience Research Communications9179188Perez, R.M.Cerezo A., Sanz, N. and Hernandez, R.CB PHARMACOLOGYPrenatal and Adjut Treatments with THC: Effects on Hormone Levels and Sexual Behaviour in Males Ratsqb==2/,+ Drug and Alcohol Dependence42155166Lucia GarciaRosario de Miguel, Jose A. Ramos, J. Javier Fernandez-RuizCB PHARMACOLOGYPerinatal Delta-9-tetrahydrocannabinol exposure in rats modifies the responsiveness of midbrain dopaminergic neurons in adjulthood to a variety of challenges with dopaminergic drugs44444p66*'$" Mammalian Genome8301302M. Pfister-GenskowG.D. Weesner, H. Hayes, A. Eggen, M.D. BishopCB RECEPTORPhysical and genetic localization of the bovine cannabinoid receptor (CNRl) gene to bovine Chromosome 9h]00 of Immunoassay17321342Hiroyuki TanakaYuri GOTO, Yukihiro ShoyamaCB ANALYTICALMonoclonal Antibody Based Enzyme Immunoassay for Marihuana (Cannabinoid) CompoundsTG,, American Journal of Botany84336342Eun-Soo KimPaul G. MahlbergCBINMUNEImmunochemical Localization of Tetrahydrocannabinol (THC) in Cryofized Glandular Trichomes of Cannabis (Cannabaceae)LD44)&#! 877M.Yu. BobrovA.V. Archakov, G.S. Kogteva, E.V. Fomina-Ageeva, G.N. Zinchenko, N.M. Gretskaya, D.V. Kuklev, and V.V. BezuglovAEAKinetics of Oxidation of Ethanolamides of Arachidonic (Anandamide) and Eicosapentaenoic Acids by Soybean 15-Lipoxygenase  iAnalytical Toxicology20441452Marilyn A. HuestisJohn M. Mitchell, and Edward J. ConeCB ANALYTICALUrinary Excretion Profiles of 11-Nor-9-Carboxy-Delta-9-Tetrahydrocannabinol in Humans after Single Smoked Doses of MarijuanagZ66$! Schizophrenia Res24213D. Cyril D'SouzaR.Gil, E.Zuzarte, L. Zimmerman, D. Abi-Saab, D. Damon, J.White, M. Sernyak and J. KrystalCB PHARMACOLOGYTetrahydrocannabinol Effects in Schizophrenic Subjects & Healthy Controlsޕ-- oJ>5"QbLipid Mediators Cell Signalling145761Natsuo UedaYuko Kurahashi, Kei Yamamoto, Shozo Yamamoto, Takashi TokunagaAAEEnzymes for anandamide biosynthesis and metabolismxu77,*(& Lipid Mediators Cell Signalling145156Takayuki SugiuraSachiko Kondo, Akihiro Sukagawa, Takashi Tonegawa, Shinji Nakane, Atsushi Yamashita, Keizo WakuAAEN-Arachidonylethanolamine (anadamide), an endogenous cannabinoid receptor ligand, and related lipid molecules in the nervous tissues"""""<<,*(& Lipid Mediators Cell Signalling144549R. MechoulamS. Ben Shabat, L. Hanus, E. Fride, Z. Vogel, M. Bayewitch, A.E. SulcovaAAEEndogenous cannabinoid ligands-chemical and biological studies88,*(& Biological Chemistry2711064010647Xiang-Qun XieLawrence S. Melvin, and Alexandros MakriyannisCB SAR/CBReceptorThe Conformational Properties of the Highly Selective Cannabinoid Receptor Ligand CP-55,940tc55(# Research Comm in Alcohol and Substance of Abuse17143149Yuichiro KayanoKazuhito Watanabe, Tamihide Matsunaga, Ikuo Yamamoto and Hidetoshi YoshimuraCB METABOLISMFatty Acid Conjugates of 11-Hydroxy-Delta-8-Tetrahydro-Cannabinol: In Vitro Formation and Hydrolysis by the Mouse Pancreas!!!!!MM>;86 Research Comm in Alcohol and Substances of Abuse17135141Yuichiro KayanoKazuhito Watanabe, Tamihide Matsunaga, Ikuo Yamamoto and Hidetoshi YoshimuraCB METABOLISMA Property of a Novel Esterase (ES46.5K) From Mouse Hepatic Microsomes: Hydrolysis of Acylated Derivatives of 11-Hydroxy-Delta-8-Tetrahydrocannabinol=====NN?<97 Research Commun in Alcohol and Substances of Abuse17151163Yuji TateokaNoriyuki Usami, Kazuhito Watanabe, and Ikuo YamamotoCB METABOLISMSynthesis and Pharmacological Effects of Chimera Derivative of Tetra-Hydrocannabinol and Phenobarbital, Tetrahydro-6,6-Dimethyl-9-[5'-Phenyl-2',4',6'-(1'H,3'H,5'H)-Pyrimidinetrionyl]-3-Pentyl-6H-Dibenzo[b,d]Pyran-Ol (TP)jjjjjMMA>;9 M>gLife Sciences6023612371T. WengerG. Fragkakis, P. Giannikou, K. Probonas, N. YiannikakisAEA/CB DEVELOPMENTEffects of Anandamide on Gestation in Pregnant Ratsp^'' European J. Pharmacology327R1R2Gian Luigi GuessaMaria Stefania Mascia, Maria Antonietta Casu, Giovanna CartaCB RECEPTOR/Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716As77&$" Drug and Alcohol Dependence453945Sandra P. WelchAEACharacterization of anandamide-induced tolerance: comparison to Delta9-THC-induced interactions with dynorphinergic systems:777(&$" Molecular Brain Research46100108J. RomeroE. Garcia-Palomero, J.G. Castro, L. Garcia-Gil, J.A. Ramos, J.J. Fernandez-RuizCB RECEPTOREffects of chronic exposure to Delta9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions00'$! Molecular Neuroscience88391Maria L. HernandezLucia Garcia-Gil, Fernando Berrendero, Jose A. Ramos, and J. Javier Fernandez-Ruiz.CB DEVELOPMENTDelta 9-Tetrahydrocannabinol Increases Activity of Tyrosine Hydroxylase in Cultured Fetal Mesencephalic Neurons44"  Int. J. Immunopharmac18749752Ronald G. CoffeyElizabeth Snella, Karen Johnson and Susan ProssCB IMMUNEInhibition of Macrophage Nitric Oxide Production by Tetrahydrocannabinol In Vivo and In Vitrolc44$! Neuroscience1666016611William J. MartinAndrea G. Hohmann and J. Michael WalkerCB SARSuppression of Noxious Stimulus-Evoked Activity in the Ventral Posterolateral Nucleus of the Thalamus by a Cannabinoid Agonist: Correlation between Electrophysiological and Antinociceptive Effects [U.. British Journal of Pharmacology12013971398Yannick P. ManeufJonathan M. BrotchieCB ReceptorParadoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slicesaVBB1-)& >2JzTheochem207114Amiran GoldblumOmar DeebSAR-SR141716ASemiemprical MNDO/H Calculations of Opiates. Part 1. Building blocks: confrmations of piperidine derivatives and the effect of hydrogen bonding:-$$ Acta Cryst.C4915021507R.B. BarlowJ.A.K. Howqard and A.S. Batsanov, D.O'Shea and D.L. RathboneSAR-SR141716AStructures of N-Benzyl- and N-Cyclohexyl-methyl-(4-diphenylacetoxy)piperidinesqd(( Bull.Chem.Soc.Jpn6710691073N. SukumarM.N. Ponnuswamy, J.C. Thenmozhiyal and R. JeyaramanSAR-SR141716AStructural Investigation of 2,6-Di-2-furyl-3,5 -dimethyl-4-piperidinone and Its N-Nitroso Derivative in Solution and the Solid State-Influence of the Nitroso Moiety on the Conformation of the Piperidine Ring and Orientation of Its Substituents_____l_,," Acta CrystB51823835Bashir M. Sheikh-AliMiroslav Rapta, Geoffrey B. Jameson and Richard G. WeissSAR-SR141716AMolecular Conformations and Crystal Packing Properties of Five 4-Alkyl-N-(4-cyanophenyl) piperidines by X-ray Diffraction: a Surprising Dependence upon Alkyl Chain Lengthsf.. Eur. J. Med Chem26775785J.A. LawsonL. Toll, W. Polgar, ET Uyeno, GH LoewSAR-SR141716AStructure-activity studies of morphine fragments. III. Synthesis, opiate receptor binding, analgetic activity and conformational studies of spiro-[tetralin-1,4'-piperidines] \O** Recl.Trav.Chim.Pays-Bas112151160Gerard D.H. DijkstraSAR SR-141716AConformational analysis of 1-arylpiperazines and 4-arylpiperidinesI;;;'$! J. Phys. Chem.9921942207Feng ZhouKlaus SchultenLIPID/CALCULATIONSMolecular Dynamics Study fo a Membrane-Water Interface~~~~~H6(( Molecular Simulation10335362Terry R. StouchLIPID/CALCULATIONLipid Membrane Structure and Dynamics Studied by All-Atom Molecular Dynamics Simulations of Hydrated Phospholipid BilayersC222#  > duNeuroendocrinology65446452April L. JacksonLaura L. MurphyCB PharmacologyRole of the Hypothalamic-Pituitary-Adrenal Axis in the Suppression of Luteinizing Hormone Release by Delta-9-TetrahydrocannabinolO@11! Critical Reviews in Neurobiology11143166Lisa A. MatsudaCB PharmacologyMolecular Aspects of Cannabinoid ReceptorswwwwwM>>>/,)' Mechanisms of Ageing and Development96117126Lakshmi RamarathianamSusan Pross, Otto Plescia, Cathy Newton, Ray Widen, Herman FriedmanCB Immune SystemDifferential immunologic modulatory effects of tetrahydrocannabinol as a function of ageHH30-+ Pharmacology and Experimental Therapeutics28110301037Kristy D. LakeDavid R. Compton, Karoly Varga, Billy R. Martin and George KunosCB RECEPTORJJ<841 Biotechnology Letter19425428Bernard CalandraJulie Tucker, David Shire and Reinhard GrisshammerCB RECEPTORExpression in Escherichia coli and characterisation of the human central CB1 and peripheral CB2 cannabinoid receptorspe33#  Science276812816M.H. B. StowellT.M. McPhillips, D.C. Rees, S.M. Soltis, E. Abresch, G. FeherGPCR ActivationLight-Induced Structural Changes in Photosynthetic Reaction Center: Implications for Mechanism of Electron-Proton Transferrc&& Indian Journal of Biochemistry & Biophysics33391397Shantaram KamathEvans CoutinhoPiperidinesMolecular mechanics calculation of opioid ligands of the 4-arylpiperidine classcXJJ:742 Computer-Aided Molecular Design5205212Raymond J. AbrahamCraig J. Medforth and Paul E. SmithPiperidinesConformational analysis. Part 16* Conformational free energies in substituted piperidines and piperidinium saltsmb??-*'& Recl.Trav.Chim.Pays-Bas112151160Gerard D.H. KijkstraSAR-SR-141116AConformational Analysis of 1-arylpiperazines and 4-arylpiperidinesI;;;'$! >Y"nrK+Biochemical and Biophysical Research Communication231217221D.G. DeutschS. Lin, W.A.G. Hill, K.L. Morse, D. Salehani, G.Arreaza, R.L. Omeir, and A MakriyannisANANDAMIDEFatty Acid Sulfonyl Fluorides Inhibit Anandamide Metabolism and Bind to the Cannabinoid ReceptorNNB?<9 Molecular Reproduction and Development45183192Bibhash C. PariaDale D. Deutsch and Sudhansu K. DeyDEVELOPMENT ANANDAMIDEThe Uterus Is a Potential Site for Anandamide Synthesis and Hydrolysis: Differential Profiles of Anandamide Synthase and Hydrolase Activities in the Mouse Uterus During the Periimplantation PeriodCCCCC~hEE52/- Pharmacology and Experimental Therapeutics282243247Karen A. WilloughbySandra F. Moore, Billy R. Martin and Early F. EllisANANDAMIDEThe Biodisposition and Metabolism of Anandamide in MiceMM:741 Neurochemistry69631638Cecilia J. HillardWilliam S. Edgemond, Abbas Jarrahian, and William B. CampbellANANDAMIDEAccumulation of N-Arachidonylethanolamine (Anandamide) into Cerebellar Granule Cells Occurs via Facilitated Diffusionvl// J. Lipid Mediators Cell Signalling154967Evguenii V. BerdyshevElisabeth Boichot, Vincent LagenteANANDAMIDEAnandamide - a new look on fatty acid ethanolamidespfDD/-+) European Journal of Pharmacology330231240Evguenii V. BerdyshevElisabeth Boichot, Noella Germain, Nathalie Allain, Jean-Pierre Anger, Vincent LagenteANANDAMIDEInfluence of fatty acid ethanolamides and Delta-9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells%%%%%EE0-*' Drug Development Research37138A. Michiel van RheeKenneth A. JacobsonGPCR reviewMolecular Architecture of G Protein-Coupled ReceptorsVK88%#"  Analytical Toxicology21240242M.A. ElSohyS. Feng, W.J. Kopycki, T.P. Murphy, A. B. Jones, A. Davis and D. CarrCB AnalyticalA Procedure to Overcome Interferences Caused by the Adulterant "Klear" in the GC-MS Analysis of 11-nor-Delta-9THC-9-COOHt//$! >^_Chemistry and Physics of Lipids87103110Patricia C. SchmidToyoyasu Kuwae, Randy J. Krebsbach, Harald H.O. SchmidANANDAMIDEAnandamide and other N-acylethanolamines in mouse peritoneal macrophagesȀv@@.+(& Pharmacology Biochemistry and Behavior587378Paola MassiGabriela Patrini, Tiziana Rubino, Domenica Fuzio and Daniela ParolaroCB RECEPTORChanges in Rat Spleen Cannabinoid Receptors after Chronic CP-55,940: An Autoradiographic玃>>31/- PHARMACOLOTY74129180Roger G. PertweePHARMACOLOGYPharmacology of Cannabinoid CB1 and CB2 Receptorshhhhh7+++ Biochemical Pharmacology5314771484Woo S. KohRobert B. Crawford and Norbert E. KaminskiBIOCHEMISTRYInhibition of Protein Kinase A and Cyclic AMP Response Element (CRE-Specific Transcription Factor Binding by Delta-9-THCi]33)%! Life Scieces61PL115118Keiko HosohataRaymond M. Quock, Yoshiaki Hosohata, Thomas H. Burkey, Alexandros Makriyannis, Paul Consroe, William R. Roeske and Henry I. YamamuraCB RECEPTORAM630 is a Competitive Cannabinoid Receptor Antagonist in the Guinea Pig Brain++ Biochimica et Biophysica Acta1307132136David ShireBernard Calandra, Murielle Rinaldi-Carmona, Didier Oustric, Bernard Pessegue, Odile Bonnin-Cabanne, Gerard Le Fur, Daniel Caput, Pascual FerraraRECEPTOR/CB RECEPTORMolecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor9999999.+($ Pharmacology and Experimental Therapeutics281730737George Pugh, Jr.David J. Mason, Jr., Vera Combs and Sandra P. WelchANALGESIAInvolvement of Dynorphin B in the Antinociceptive Effects of the Cannabinoid CP55,940 in the Spinal Cord}JJ:741 Natur388773778Nephi StellaPaul Schweitzer, Daniele PiomelliANANDAMIDEA second endogenous cannabinoid that modulates long-term potentiationLB!!  +>L-)PENeuropsychobiology369699Andrew N. GiffordEliot L. Gardner, Charles R. Ashby, Jr.PHARMACOLOGYThe Effect of Intravenous Administration of Delta-9-Tetrahydrocannabinol on the Activity of A10 Dopamine Neurons Recorded in vivo in Anesthetized RatscW00 Jpn J. Ophthalmol41217220Yoichi MikawaSatoshi Matsuda, Tomoko Kanagawa, Tomoyuki Tajika, Natsuo Ueda and Yasuo MimuraANANDAMIDEOcular Activity of Topically Administered Anandamide in the RabbitȆ|--  Jenny L. WileyKeith M. Golden, William J. Ryan, Robert L. Balster, Raj K. Razdan, and Billy R. MartinANANDAMIDEEvaluation of Cannabimimetic Discriminative Stimulus Effects of Anandamide and Methylated Fluoroanandamide in Rhesus Monkeysvl a118William, RyanKenneth W. Banner, Peter J. Crocker, David R. Compton, Billy R. Martin, Raj K. RazdanANANDAMIDEPotent Ananadamide Analogs: The Effect of Changing the Length and Branching of the End Pentyl Chainvl  yJ. Clin. Invest.138Dale DeutschMichael S. Goligorsky, Patricia C. Schmid, Randy J. Krebsbach, Harald H.O. Schmid, S.K. Das, S.K. Dey, G. Arreza, Christian Thorup, George B. Stefano, and Leon C. Moore.ANANDAMIDEProduction, Binding, and Vascular Actions of Anandamide in the Rat Kidney"""""&& { NIDA Technical Review on Pharmokinetics, Metaboli6584Dale G. DeutschAlexandros MakriyannisANANDAMIDEInhibitors of AnandamidelbLL=;99 {Biochemical and Biophysical Research Communication231217221D.G. DeutschS. Lin, W.A. G. Hill, K.L. Morse, D. Salehani, G. Arreaza, R.L. Omeir and A. MakriyannisANANDAMIDEFatty Acid Sulfonyl Fluorides Inhibit Anandamide Metabolism and Bind to the Cannabinoid ReceptorNNB?<9 Naunya-Schmiedeberg's Arch Pharmacol356197202Barbara MalinowskaGrzegorz Godlewski, Bernard Bucher, Eberhard SchlickerCB RECEPTORCannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat|FF41.+ 4> 06E.PAnalytical Toxicoly21283285Richard E. StruemplerGordon Nelson, and Francis M. UrryFORENSICSA Positive Cannabinoids Workplace Drug Test Following the Ingestion of Commercially Available Hemp Seed OilbY77" Brain Research7636368George B. StefanoBeatrice Salzet, Christos M. Rialas, McElvin Pope, Adam Kustka, Kevin Neenan, Stephen Pryor and Michel SalzetANANDAMIDEMorphine- and anandamide-stimulated nitric oxice production inhibits presynaptic dopamine release-- The American Physiological Society4350W. TwitchellS. Brown and K. MackieRECEPTORCannabinoids Inhibit N- and P/Q-Type Calcium Channels in Cultured Rat Hippocampal NeuronsWO99-+)) {Psychopharmacology132104106Michele ArnoncJeanne Maruani, Frederique Chaperon, Marie-Helene Thiebot, Martine Poncelet, Philippe Soubrie and Gerard Le FurANTAGONISTSelective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors00" International J. of Psychology313844Brown R.Dastur, R. McLennan A. and McGregor I.SARThe cannabinoid agonist CP55,940 reduces ultrasonic vocalizations of infant rats\Y33++'% oSciece27710941097M. BeltramoN. Stella, A. Calignano, S.Y. Lin, A. Makriyannis, D. PiomelliANANDAMIDEFunctional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibitionka##  Computer Aided Molecular Design11278292Silke SchmetzerPaulette Greenidge, Karl-Artur Kovar, Meike Schulze-Alexandru and Gerd FolkersSARStructure-activity relationships of cannabinoids: A joint CoMFA and pseudorecptor modelling study==.+(& TIBS21171172Steven HowellPhilippe CrineGPCR GENERALType VI membrane proteins?TTTTT:.   Nature3892526Raphael MechoulamEster Fride, Lumir Hanus, Tzviel Sheskin, Tiziana Bisogno, Vincenzo Di Marso, Michael Bayewitch, Zvi VogelANANDAMIDEAnandamide may mediate sleep induction%%  >(n{JPET27516Jenny L. Wiley,John A. Lowe, Robert L. Balster and Billy MartinCB RECEPTORAntagonism of the Discriminative Stimulus Effects of Delta-9-Tetrahydrocannabinol in Rats and Rhesus MonkeysZO  Nature382677678Emmanuelle di TomasoMassimiliano Beltramo and Daniele PiomelliCB RECEPTOR/AEABrain cannabinoids in chocolatecT**  European Journal of Pharmacology3181116Ignacio RecheJose A. Fuentes, Mariano Ruz-GayoANALGESIAPotentiation of Delta-9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of mu-and k-opioid receptorse\;;.,*' Current Medicinal Chemistry3101116J.W. HuffanJ.A. LaintonCBSARRecent Developments in the Medicinal Chemistry of CannabinoidsE@44)&#" Biorganic & Medicinal Chemistry622632268Michel GallantClaude Dufresne, Yves Gareau, Daniel Guay, Yves Leblanc, Petpiboos Prasti, Chantal Rochette, Nicole Sawyer, Debora M. Slipetz, Nathalie Tremblay, Kathleen M. Metters and Marck LabelleCBSAR/CBRECEPTORNew Class of Potent Ligands for the Human Peripheral Cannabinoid ReceptorMMMMM==/+'& Diabetes461321Xinguang Li,Norbert E. Kaminski, Lawrence J. FisherIMMUNOLOGYMultiple Low Dose Streptozotocin Diabetes Is Attenuated by Delta-9-TetrahydrocannabinolRH!! oMolecular Biology of the Cell ASCB meeting73764Helen McIntoshChao Son, and Allyn C. HowlettCB RECEPTORStudies on Cannabinoid Receptor Regulation and Distribution in N18TG2 CellsmbDD6621 oBrain Research763137140Akira MiyamotoTsuneyuki Yamamoto, Masuo Ohno and Shigenori WatanabeBIOCHEMISTRYDesensitization of Fos protein induction in rat striatum and nucleus accumbens following repeated administration of Delta-9-tetrahydrocannabinolma,, > 8Tetrahedron Letters3831933194David A. EvansEileen A. Shaughnessy, and David M. BarnesSYNTHESISCationic Bis(oxazoline)Cu(II) Lewis Acid Catalysts. Application to the Asymmetric Synthesis of ent-Delta-1-Tetrahydrocannabinole\22$  European Journal of Pharmacology324187192Andrew N. GiffordLaila Samiian, S. John Gatley, Charles R. Ashby Jr.CB RECEPTORExamination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slices tAA0-*' Naunyn-Schmiedeberg's Archives of Pharmacology35571B. MalinowskaG. Godlewski, B. Bucher, E. SchlickerBIOCHEMISTRYEffects of Cannabinoid Receptor Agonists on the Neurogenic Vasopressor Response in the Pithed Rat and on Noradrenaline Release in the Rat Tail Artery xlGG::85 oNeurochemical Research22563568A.S. BloomW.S. Edgemond and J.C. MoldvanMEMBRANENonclassical and Endogenous Cannabinoids: Effects on the Ordering of Brain MembranesUM//%" Forensic Sci42610618R. Martin SmithSARIdentification of Butyl Cannabinoids in Marijuana^^^^^-*** Brain Research753219224George B. StefanoBeatrice Salzet, Michel SalzetCB RECEPTORIdentification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide releaseXM// European Journal of Pharmacology323193195Javier CorcheroJose Fuentes, Jorge ManzanaresGENETICSDelta-9-Tetrahydrocannabinol increases proopiomelanocorting gene expression in the arcuate nucleus of the rat hypothalamuse]??0-*' DNA and Cell Biology16301309Yehia DaakaWeigang Zhu, Herman Friedman and Thomas W. KleinGENETICSInduction of Interleukin-2 Receptor alpha Gene by Delta-9-Tetrahydrocannabinol Is Mediated by Nuclear Factor kB and CB1 Cannabinoid Receptorf^..#   >%Life Sciences6015631573Sheila A. HunterSumner H. BursteinANANDAMIDEReceptor Mediation in Cannabinoid Stimulated Arachidonic Acid Mobilization and Ananddamide SynthesisJ@.. European Journal of Pharmacology323R3R4Thomas H. BurkeyRaymond M. Quock, Paul Consroe, William R. Roeske, Henry I. YamamuraCB RECEPTORDelta-9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain捂>>.,*' Proc.Natl. Acad.Sci9441884192Patricia C. SchmidB. C. Paria, Randy J. Krebsach, Harald H. O. Schmid, and S.K. DeyANANDAMIDEChanges in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantationw66$  Journal of Analytical Toxicology21213242Joan C. CagleH. Horton McCurdy, Y. Mary Pan, Kim J. Ayton, William H. Wall, and Everett T. SolomonsFORENSICSEvaluation of the CEDIAtm DAU Assays and the AxSymtm System for the Analysis of Cannabinoids in Whole Blood< 7qKo9Brain Research Bulletin43173178Francisco Molina-HolgadoFrancisco J. Alvarez, Isabel Gonzalez, Maria T. Antonio and Maria L. LeretDEVELOPMENTMaternal Exposure to Delta-9-Tetrahydrocannabinol (Delta-9-THC) Alters Indolamine Levels and Turnover in Adjult Male and Female Rat Brain Regions$$$$$>>&#  Science27620482050Gianluigi TandaFrancesco E. Pontieri, Gaetano Di ChiaraCB RECEPTORCannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common mu-1 Opioid Receptor Mechanism[P((  Science27619671968Ingrid WickelgrenCB RECEPTORMarijuana: Harder Than Thought?UUUUU5***  Drug Metabolism and Disposition20241246Lester M. BornheimJerome M. Lasker and Judy L. RaucyMETABOLISMHuman Hepatic Microsomal Metabolism of Delta-1-Tetrahydrocannabinollb@@.+(&  Biological Mass Spectromety20292302D.J. HarveyN.K. BrownMETABOLISINElectron Impact-induced Fragmentation of the Trimethylsilyl Derivatives of Monohydroxy-hexahydrocannabinolsJ?55*'$"  Naunyn Schmiedeberg Archives of Pharmacology355319Lutz DomerWolfgang Norenberg, Klaus Starke and Bela SzaboBIOCHEMISTRYElectrophysiological Effects of Cannabinoids on Striatal and Cerebellar Neurons~rCC9963 o Naunyn Schmiedeberg Archives of Pharmacology355320E. SchlickerJ. Timm, M. GothertBIOCHEMISTRYCannabinoid Receptor-Mediated Inhibition of Noradrenaline Release and cAMP Accumulation in the Guinea-Pig and Human BraindXEE9963 oPharmacology Biochemistry and Behavior56803807Hinderk M. EmriciiF. Markus Leweke and Udo SchneiderCB RECEPTORToward a Cannabinoid Hypothesis of Schizophrenia: Cognitive Impairments Due to Dysregulation of the Endogenous Cannabinoid SystemtiGG52/- Sciece27620502054Fernando Rodriguez de FonsecaM. Rocio A. Carrera, Miguel Navarro, George F. Koob, Friedbert WeissPHARMACOLOGYActivation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawaly55  o> P{=q bACS Div of Medicinal Chemistry Abstract41041Emip PopStanislaw Rachwal, Anat Biegon, Sarina Striem and Marcus E. BrewsterSARSynthetic Cannabinoids with Potential Neuroprotective ActivityĆ??7742 oNuclear Medicine38116PSJ GaileyAN Gifford, R Lan, C. Wong B. Pyan, N. Pappas, ND Volkow Wag Hill, A MakriyannisCB RECEPTORSpect Imaging of Brain Cannabinoid Receptorsv&& oAmitabha ChakrabartiJethro E. Ekuta and Emmanuel S. OnaiviANANDAMIDENeurobehavioral Effects of Anandamide and Cannabinoid Receptor Gene Expression in MiceKA aMammalian Genome7165166L. StubbsL. Chittenden, A. Chakrabarti, E. OnaiviCB RECEPTORThe gene encoding the central cannabinoid receptor is located in proximal mouse Chromosome 4ZO'' Pharmacology and Experimental Therapeutics25310021009Emmanuiel S. OnaiviMaude R. Green and Billy R. MartinPHARMACOLOGYPharmacological Characterization of Cannabinoids in the Elevated Plus Maze}qOO<841 Life Sciences6017091717Cristina SanchezGuilermo Velasco and Manuel GuzmanCB METABOLISMMetabolic Stimulation of Mouse Spleen Lymphocytes by Low Doses of Delta-9-Tetrahydrocannabinol]P.. Drug Discovery Today1534535CB RECEPTOR------"""" ?Behavioural Brain Research72115125E.S. OnaiviA. Chakrabarti, E.T. Gwebu, G. ChaudhuriCB RECEPTORNeurobehavioral effects of Delta-9-THC and cannabinoid (CB1) receptor gene expression in miceg\44)&#! Progress in Neurobiology48275305Emmanuel S. OnaiviAmitabha Chakrabarti and Gautam ChaudhuriGENETICS/CB RECEPTORCannabinoid Receptor Genesvb99'$! Biochemical and Biophysical Research Communication2318288L. De PetrocellisD. Melck, N. Ueda, S. Maurelli, Y. Kurahashi, S. Yamamoto, G. Marino, and V. Di MarzoANANDAMIDENovel Inhibitors of Brain, Neuronal, and Basophilic Anandamide AmidohydrolaseQQ@><9 >[ Virology7167966804Peter J.M. ValkSamantha Hol, Yolanda Vankan, James N. Hle, David Askew, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, Nico J. de Both, Bob Lowenberg and Ruud DewelCB RECEPTORThe Genes Encoding the Peripheral Cannabinoid Receptor and alpha-L-Fucosidase Are Located near a Newly Identified Common Virus Integration Site, Evilleeeee(( Ann Clin Biochem34460510D. SimpsonR. A. Braithwaite, D. R. Jarvie, M.J. Stewart, S. Walker, I. W. Watson and B. WiddopCB ANALYTICALScreening for drugs of abuse (II): cannabinoids, lysergic acid diethylamide, buprenorphine, methadone, barbiturates, benzodiazepines and other drugs. })) Pharmacology Biochemistry and Behavior57625631A.S. BloomS. Tershner, S.A. Fuller and E.A. SteinCB RECEP TORCannabinoid-Induced Alterations in Regional Cerebral Blood Flow in the Ratrf??52/- Blood9014481457Peter ValkSandra Verbakel, Yolanda Vankan, Smantha Hol, Shanta Mancham, Rob Ploemacher, Angelique Mayen, Bob Lowenberg, and Ruud DelvelANANDAMIDEAnadamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells'''''   Annu. Rev.Cell Biol6247296S.J. SingerGPCR GENERAL/GPCR STRUCTUREThe Structure and Insertion of Integral Proteins in MembranesG,,,! 15571566Angela A. CouttsRoger G. PertweeCB PHARMACOLOGY/CB RECEPTORInhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexusJ/  yBritish Journal of Pharmacology12117161720Susanthi R. FernandoRoger G. PertweeANANDAMIDE/CB RECEPTOREvidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonistkUEE1-)& > (7f:)Biochem316977984Vincenzo Di MarzoLuciano De Petrocellis, Nunzio SEPE and Anna BUONOAEABiosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells]Z(( (Psychopharmacology126125131Aron H. LichtmanBilly R. MartinCB RECEPTORDelta-9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanismLA22" 'Life Sciences59659668Dana E. SelleySheryl Stark, Laura J. Sim and Steven R. ChildersCB RECEPTORCannabinoid Receptor Stimulation of Guanosine-5'-0-(3-[35S]THIO) Triphosphate Binding in Rat Brain Membranesf[** &European J. of Pharmacology307331338S. John GatleyAndrew N. Gifford, Nora D. Volkow, Ruoxi Lan, Alexandros MakriyannisCB SAR/CB RECEPTOR}99+(%" %Colloids and Surfaces Physicochemical Eng. Aspects91181190Shaul MuchtarSimon BenitaCB OCULAR EFFECTSEmulsions as drug carriers for ophthalmic usekZNNA>;9 $Journal of Cardiovascular Pharmacology28332336H. VidrioM.A. Sanchez-Salvatori, and M. MedinaCB SARCardiovascular Effects of (-)-11-OH-Delta-8-Tetrahydrocannabinol-Dimethylheptyl in Ratsic>>52/- #British Journal of Pharmacology11821992205Roger G. PertweeSusanthy R. Fernando, Joanne E. Nash & Angela A. CouttsCB RECEP TORFurther evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestinexAA1-)& "British Journal of Pharmacology11820532058Roger G. PertweeSusanthi R. FernandoCB RECEPTOREvidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder`UAA1-)& !